Author | dc.contributor.author | Carrasco, Cristian | |
Author | dc.contributor.author | Tittarelli, Andrés | |
Author | dc.contributor.author | Paillaleve, Natalia | |
Author | dc.contributor.author | Pozo, Maeva del | |
Author | dc.contributor.author | Rojas Sepúlveda, Daniel Alberto | |
Author | dc.contributor.author | Barría Catricura, Omar André | |
Author | dc.contributor.author | Fluxá Rojas, Paula Andrea | |
Author | dc.contributor.author | Hott, Melissa | |
Author | dc.contributor.author | Martin, Carolina | |
Author | dc.contributor.author | Quezada Monrás, Claudia Andrea | |
Author | dc.contributor.author | Salazar Onfray, Flavio Andres | |
Admission date | dc.date.accessioned | 2021-11-29T22:26:46Z | |
Available date | dc.date.available | 2021-11-29T22:26:46Z | |
Publication date | dc.date.issued | 2021 | |
Cita de ítem | dc.identifier.citation | Diagnostics 2021, 11, 153 | es_ES |
Identifier | dc.identifier.other | 10.3390/diagnostics11020153 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/182946 | |
Abstract | dc.description.abstract | Gallbladder cancer (GBC) is an aggressive and highly lethal disease with relatively low global incidence, but one that constitutes a major health problem in Asian and Latin American countries, particularly in Chile. The identification of new tumor-associated markers with potential prognosis value is required for GBC clinical practice. Using immunohistochemistry/tumor tissue microarray, we evaluated the expression of 17 gastrointestinal tumor-associated protein markers (CK7, CK17, CK19, CK20, CKLMW, CKHMW, MUC1, MUC2, MUC5AC, MUC6, CA125, CD10, CEA, vimentin, villin, claudin-4, and CDX2) in primary gallbladder adenocarcinomas from 180 Chilean patients and analyzed potential associations with their pathological and clinical characteristics. Younger female patients with well-to moderately differentiated tumors had a better prognosis than that of older female or male patients with tumors with a similar tumor differentiation grade. Among all analyzed markers, MUC6 expression was associated with better prognosis in patients with well-to moderately differentiated tumors, whereas CK17 or CD10 was associated with worse prognosis in patients with poorly differentiated tumors. In addition, the MUC6(+)CK17(-) expression pattern was strongly associated with better prognosis in patients with well- to moderately differentiated tumors, whereas patients with poorly differentiated tumors and with the CK17(+)CD10(+) expression pattern showed worse prognosis. Our results suggest that tumor MUC6, CK17, and CD10 can be considered as potential prognosis markers for GBC. | es_ES |
Patrocinador | dc.description.sponsorship | Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT 1171213
1160777
11160380
Millennium Science Initiative from the Ministry for the Economy, Development, and Tourism P09/016-F
Fund Innovation for Competitiveness, Region de Los Rios FIC19-70 | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | MDPI | es_ES |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
Source | dc.source | Diagnostics | es_ES |
Keywords | dc.subject | Gallbladder cancer | es_ES |
Keywords | dc.subject | Prognosis | es_ES |
Keywords | dc.subject | Biomarkers | es_ES |
Keywords | dc.subject | Mucin 6 | es_ES |
Keywords | dc.subject | Cytokeratin 17 | es_ES |
Keywords | dc.subject | CD10 | es_ES |
Keywords | dc.subject | Immunohistochemistry | es_ES |
Keywords | dc.subject | Tissue microarray | es_ES |
Título | dc.title | The evaluation of 17 gastrointestinal tumor markers reveals prognosis value for MUC6, CK17, and CD10 in gallbladder-cancer patients | es_ES |
Document type | dc.type | Artículo de revista | es_ES |
dc.description.version | dc.description.version | Versión publicada - versión final del editor | es_ES |
dcterms.accessRights | dcterms.accessRights | Acceso abierto | es_ES |
Cataloguer | uchile.catalogador | apc | es_ES |
Indexation | uchile.index | Artículo de publícación WoS | es_ES |