Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review
Author
dc.contributor.author
Arancibia, Trinidad
Author
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Morales Pisón, Sebastián
Author
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Maldonado Maldonado, Edio Luis
Author
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Jara Sosa, Lilian Elena
Admission date
dc.date.accessioned
2021-12-02T13:28:03Z
Available date
dc.date.available
2021-12-02T13:28:03Z
Publication date
dc.date.issued
2021
Cita de ítem
dc.identifier.citation
Biol Res (2021) 54:26
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Identifier
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10.1186/s40659-021-00349-z
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/183006
Abstract
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Breast cancer (BC), a heterogeneous, aggressive illness with high mortality, is essentially a genomic disease. While
the high-penetrance genes BRCA1 and BRCA2 play important roles in tumorigenesis, moderate- and low-penetrance
genes are also involved. Single-nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes have recently been
identifed as BC risk factors. miRNA genes are currently classifed as low-penetrance. SNPs are the most common vari‑
ations in the human genome. While the role of miRNA SNPs in BC susceptibility has been studied extensively, results
have been inconsistent. This review analyzes the results of association studies between miRNA SNPs and BC risk
from countries around the world. We conclude that: (a) By continent, the largest proportion of studies to date were
conducted in Asia (65.0%) and the smallest proportion in Africa (1.8%); (b) Association studies have been completed
for 67 diferent SNPs; (c) 146a, 196a2, 499, 27a, and 423 are the most-studied miRNAs; (d) The SNPs rs2910164 (miRNA146a), rs11614913 (miRNA-196a2), rs3746444 (miRNA-499) and rs6505162 (miRNA-423) were the most widely associ‑
ated with increased BC risk; (e) The majority of studies had small samples, which may afect the precision and power
of the results; and (f ) The efect of an SNP on BC risk depends on the ethnicity of the population. This review also
discusses potential explanations for controversial fndings.
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Patrocinador
dc.description.sponsorship
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT 1200049
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Lenguage
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en
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Publisher
dc.publisher
Sociedad de Biología de Chile
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Type of license
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 United States