Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans
Author
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Kehdy, Fernanda S. G.
Author
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Pita Oliveira, Murilo
Author
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Scudeler, Mariana M.
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Torres Loureiro, Sabrina
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Zolini, Camila
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Moreira, Rennan
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Michelin, Lucas A.
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Alvim, Isabela
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Silva Carvalho, Carolina
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Furlan, Vinicius C.
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Aquino, María M.
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Santolalla, Meddly L.
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Borda, Víctor
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Soares Souza, Giordano B.
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Jaramillo Valverde, Luis
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Vásquez Domínguez, Andrés
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Sánchez Neira, César
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Aguiar, Renato S.
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Verdugo Salgado, Ricardo Alejandro
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Connor, Timothy D. O.
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Guio, Heinner
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Tarazona Santos, Eduardo
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Leal, Thiago P.
Author
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Rodrigues Soares, Fernanda
Admission date
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2021-12-10T20:34:56Z
Available date
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2021-12-10T20:34:56Z
Publication date
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2021
Cita de ítem
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Genetics and Molecular Biology, 44, 1(suppl 1), e20200484 (2021)
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Identifier
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10.1590/1678-4685-GMB-2020-0484
Identifier
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https://repositorio.uchile.cl/handle/2250/183167
Abstract
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For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association
in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates
the importance of population genetics and of sequencing data in the design of genetic association studies in different
human populations: the high linkage disequilibrium (LD) between rs2070788 and rs383510 is Asian-specific. Leveraging
on a combination of genotyping and sequencing data for Native Americans (neglected in genetic studies), we show
that while their frequencies of the Asian tag-SNP rs2070788 is, surprisingly, the highest worldwide, it is not in LD
with the eQTL rs383510, that therefore, should be directly genotyped in genetic association studies of SARS in
populations with Native American ancestry.
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Patrocinador
dc.description.sponsorship
Department of Science & Technology (India)
Peruvian Genome Project from the Peruvian National Institute of Health
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) FONDEF D10I1007
D10E1007
FONDEQUIP EQM140157
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Lenguage
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en
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Publisher
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Soc Brasil Genética
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Type of license
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 United States
Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans