Author | dc.contributor.author | Torres Castro, Rodrigo Hernán | |
Author | dc.contributor.author | Gimeno Santos, Elena | |
Author | dc.contributor.author | Vilaró, Jordi | |
Author | dc.contributor.author | Roqué Figuls, Marta | |
Author | dc.contributor.author | Moisés, Jorge | |
Author | dc.contributor.author | Vasconcello Castillo, Luis Eduardo | |
Author | dc.contributor.author | Orizaga, Tanya | |
Author | dc.contributor.author | Barberà, Joan Albert | |
Author | dc.contributor.author | Blanco, Isabel | |
Admission date | dc.date.accessioned | 2022-01-10T20:54:40Z | |
Available date | dc.date.available | 2022-01-10T20:54:40Z | |
Publication date | dc.date.issued | 2021 | |
Cita de ítem | dc.identifier.citation | Eur Respir Rev 2021; 30: 200321 | es_ES |
Identifier | dc.identifier.other | 10.1183/16000617.0321-2020 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/183628 | |
Abstract | dc.description.abstract | Background Pulmonary hypertension (PH) is a frequent complication in patients with COPD.
Objective To determine if, in patients with COPD, the presence of PH decreases exercise tolerance.
Methods We included studies that analysed exercise tolerance using a cardiopulmonary exercise test
(CPET) in patients with COPD with PH (COPD-PH) and without PH (COPD-nonPH). Two independent
reviewers analysed the studies, extracted the data and assessed the quality of the evidence.
Results Of the 4915 articles initially identified, seven reported 257 patients with COPD-PH and 404
patients with COPD-nonPH. The COPD-PH group showed differences in peak oxygen consumption
(V′O2peak), −3.09 mL·kg−1·min−1 (95% CI −4.74 to −1.43, p=0.0003); maximum workload (Wmax),
−20.5 W (95% CI −34.4 to −6.5, p=0.004); and oxygen pulse (O2 pulse), −1.24 mL·beat−1 (95% CI
−2.40 to −0.09, p=0.03), in comparison to the group with COPD-nonPH. If we excluded studies with lung
transplant candidates, the sensitivity analyses showed even bigger differences: V′O2, −4.26 mL·min−1·kg−1
(95% CI −5.50 to −3.02 mL·kg−1·min−1, p<0.00001); Wmax, −26.6 W (95% CI −32.1 to −21.1 W,
p<0.00001); and O2 pulse, −2.04 mL·beat−1 (95% CI −2.92 to −1.15 mL·beat−1, p<0.0001).
Conclusion Exercise tolerance was significantly lower in patients with COPD-PH than in patients with
COPD-nonPH, particularly in nontransplant candidates. | es_ES |
Patrocinador | dc.description.sponsorship | Instituto de Salud Carlos III PI17/1515
Fondo Europeo de Desarrollo Regional (FEDER), Union Europea "Una manera de hacer Europa"
Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR)
Societat Catalana de Pneumologia (SOCAP)
National Agency for Research and Development (ANID)/Scholarship Program/DOCTORADO BECAS CHILE 2018-72190117 | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | European Respiratory Soc Journals Ltd | es_ES |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
Source | dc.source | European Respiratory Review | es_ES |
Keywords | dc.subject | Survival | es_ES |
Keywords | dc.subject | Impact | es_ES |
Keywords | dc.subject | Heart | es_ES |
Título | dc.title | Effect of pulmonary hypertension on exercise tolerance in patients with COPD: a prognostic systematic review and meta-analysis | es_ES |
Document type | dc.type | Artículo de revista | es_ES |
dc.description.version | dc.description.version | Versión publicada - versión final del editor | es_ES |
dcterms.accessRights | dcterms.accessRights | Acceso abierto | es_ES |
Cataloguer | uchile.catalogador | cfr | es_ES |
Indexation | uchile.index | Artículo de publícación WoS | es_ES |