Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population
Author
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Alvarado, Ángel Tito
Author
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Muñoz, Ana María
Author
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Saravia Bartra, María
Author
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Valderrama Wong, Milton
Author
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González Aristegui, Daniela
Author
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Quiñones Sepúlveda, Luis Abel
Author
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Varela Figueroa, Nelson Miguel
Author
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Bendezú, María Rocío
Author
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García, Jorge Antonio
Author
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Loja Herrera, Berta
Admission date
dc.date.accessioned
2022-03-03T20:17:48Z
Available date
dc.date.available
2022-03-03T20:17:48Z
Publication date
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2021
Cita de ítem
dc.identifier.citation
Pharmacia 68(4): 747–754 (2021)
es_ES
Identifier
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10.3897/pharmacia.68.e71621
Identifier
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https://repositorio.uchile.cl/handle/2250/184020
Abstract
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The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type GSTM1 (+) and 47% with null GSTM1. The frequency in Iquiteño emigrants was 0.72 CYP1A1*2A and 25% GSTM1 (-); from Lima 0.67 CYP1A1*2A and 33% of GSTM1 (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05.
The presence of the risk allele of the CYP1A1*2A polymorphism and the deletion in the GSTM1 gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.
es_ES
Lenguage
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en
es_ES
Publisher
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Pensoft
es_ES
Type of license
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Attribution-NonCommercial-NoDerivs 3.0 United States