Background. Frailty is associated with poor outcomes for haemodialysis patients, but its prevalence is uncertain due to
heterogeneous definitions. The aim of this study was to compare and contrast prevalence and features of commonly used
frailty instruments in a British haemodialysis cohort.
Methods. The FITNESS (Frailty Intervention Trial iN End-Stage patientS on haemodialysis) study recruited adults aged 18
years after informed consent, with 3 months haemodialysis exposure and no hospital admission within 4 weeks unless
for dialysis access. Study participants were clinically phenotyped with frailty instruments including the Frailty Index (FI),
Frailty Phenotype (FP), Edmonton Frailty Scale (EFS) and Clinical Frailty Scale (CFS), alongside comprehensive baseline data
collection of biochemical, clinical and social characteristics.
Results. Between 12 January 2018 and 18 April 2019, 485 haemodialysis patients were recruited. Baseline demographics were
median age 63 years, male sex 58.6% and non-White ethnicity 42.1%. Prevalence of frailty was high; 41.9% of participants
were frail by FP, 63.3% by FI, 50.2% by EFS and 53.8% by CFS. Female gender was associated with increased frailty, with no
independent association observed with age or ethnicity. While correlation between frailty instruments was strong,
intraclass correlation coefficient for frailty agreement was 0.628 (95% confidence interval 0.585–0.669) and only weak
agreement between instrument pairs.
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Patrocinador
dc.description.sponsorship
Queen Elizabeth Hospital Charity 17-3-886
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Lenguage
dc.language.iso
en
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Publisher
dc.publisher
Oxford
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Type of license
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 United States