Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
Author
dc.contributor.author
Tumani Karmy, María Fernanda
Author
dc.contributor.author
Tapia Opazo, Gladys Sofía
Author
dc.contributor.author
Aguirre, Carolina
Author
dc.contributor.author
Obregón Rivas, Ana María
Author
dc.contributor.author
Pettineli, Paulina
Admission date
dc.date.accessioned
2022-12-21T20:18:56Z
Available date
dc.date.available
2022-12-21T20:18:56Z
Publication date
dc.date.issued
2021
Cita de ítem
dc.identifier.citation
Rev Med Chile 2021; 149: 570-579
es_ES
Identifier
dc.identifier.issn
0034-9887
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/189940
Abstract
dc.description.abstract
Non-alcoholic fatty liver disease (NAFLD) encompasses a wide
spectrum of hepatic pathologies ranging from simple steatosis (SS) to
hepatocellular carcinoma. Intestinal microbiota (IM) is composed of
trillions of microorganisms existing in the gut. It has 150 times more
genes than the host. Changes in the composition and function of the
IM are associated with different diseases, including NAFLD. In this
condition, IM could have a pathogenic role through different mechanisms
such as energy salvaging from food, an inflammatory stimulus,
a modulation of the innate immune system, regulation of bile acid
turnover, alteration of choline metabolism and increasing endogenous
ethanol levels. This review is an update on the role of the intestinal
microbiota in NAFLD and the possible mechanisms involved.
es_ES
Lenguage
dc.language.iso
es
es_ES
Publisher
dc.publisher
Sociedad Médica Santiago
es_ES
Type of license
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 United States