Browsing by Author "03ea2443-abb6-4ed9-b74e-fa750c90ffee"

Now showing items 1-10 of 10

    • Aging impairs hippocampal- dependent recognition memory and LTP and prevents the associated RyR up-regulation 
      Arias Cavieres, Alejandra; Adasme, Tatiana; Sánchez, Gina; Muñoz, Pablo; Hidalgo Tapia, María Cecilia (Frontiers Research Foundation, 2017)
      © 2017 Arias-Cavieres, Adasme, Sánchez, Muñoz and Hidalgo.Recognition memory comprises recollection judgment and familiarity, two different processes that engage the hippocampus and the perirhinal cortex, respectively. ...
    • Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in ... 
      Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco, M. Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (2011)
      Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca2+ homeostasis and synaptic function. Here, we report that AβOs at sublethal concentrations ...
    • Astaxanthin counteracts excitotoxicity and reduces the ensuing increases in calcium levels and mitochondrial ... 
      García, Francisca; Lobos, Pedro; Ponce, Alejandra; Cataldo, Karla; Meza, Daniela; Farías, Patricio; Estay, Carolina; Oyarzún Ampuero, Felipe; Herrera Molina, Rodrigo; Paula Lima, Andrea; Ardiles, Álvaro O.; Hidalgo Tapia, Cecilia; Adasme, Tatiana; Muñoz, Pablo (MDPI, 2020)
      Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-beta peptide oligomers, which promote excessive ...
    • Astaxanthin protects primary hippocampal neurons against noxious effects of A β-oligomers 
      Lobos, Pedro; Bruna, Barbara; Cordova, Alex; Barattini, Pablo; Galáz, Jose Luis; Adasme, Tatiana; Hidalgo Tapia, María Cecilia; Muñoz, Pablo; Paula Lima, Andrea (Hindawi Limited, 2016)
      © 2016 Pedro Lobos et al.Increased reactive oxygen species (ROS) generation and the ensuing oxidative stress contribute to Alzheimer's disease pathology. We reported previously that amyloid-β peptide oligomers (AβOs) produce ...
    • Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural ... 
      More, Jamileth Y.; Bruna, Barbara A.; Lobos, Pedro; Galaz, Jose L.; Figueroa, Paula L.; Namias, Silvia; Sánchez, Gina; Barrientos Briones, Genaro; Valdes Guerrero, Jose; Paula Lima, Andrea; Hidalgo Tapia, María Cecilia; Adasme, Tatiana (Mary Ann Liebert Inc publishers, 2018)
      Aims: Previous studies indicate that hippocampal synaptic plasticity and spatial memory processes entail calcium release from intracellular stores mediated by ryanodine receptor (RyR) channels. In particular, RyR-mediated ...
    • Contribution of Ca2+ release channels to hippocampal synaptic plasticity and spatial memory: Potential redox ... 
      Paula-Lima, Andrea C.; Adasme, Tatiana; Hidalgo Tapia, María Cecilia (Mary Ann Liebert Inc., 2014)
      Significance: Memory is an essential human cognitive function. Consequently, to unravel the cellular and molecular mechanisms responsible for the synaptic plasticity events underlying memory formation, storage and loss ...
    • High-frequency field stimulation of primary neurons enhances ryanodine receptor-mediated Ca2+ release and ... 
      Riquelme, Denise; Alvarez, Alvaro; Leal, Nancy; Adasme, Tatiana; Espinoza, Italo; Valdés, Juan Antonio; Troncoso, Natalia; Hartel, Steffen; Segura Hidalgo, Jorge Antonio; Hidalgo Tapia, María Cecilia; Carrasco, M. Angélica (2011)
      Neuronal electrical activity increases intracellular Ca2+ concentration and generates reactive oxygen species. Here, we show that high frequency field stimulation of primary hippocampal neurons generated Ca 2+ signals with ...
    • Increased hippocampal expression of the divalent metal transporter 1 (DMT1) mRNA variants 1B and +IRE and ... 
      Haeger, Paola; Alvarez, Alvaro; Leal, Nancy; Adasme, Tatiana; Núñez González, Marco; Hidalgo Tapia, María Cecilia (2010)
      Iron is essential for crucial neuronal functions but is also highly toxic in excess. Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1). The N-terminus ...
    • RyR2-mediated Ca2+ release and mitochondrial ROS generation partake in the synaptic dysfunction caused by ... 
      San Martín Rovirosa, Carol; Veloso, Pablo; Adasme, Tatiana; Lobos, Pedro; Bruna, Barbara; Galaz, Jose; García, Alejandra; Hartel, Steffen; Hidalgo Tapia, María Cecilia; Paula Lima, Andrea (Frontiers Research Foundation, 2017)
      © 2017 SanMartín, Veloso, Adasme, Lobos, Bruna, Galaz, García, Hartel, Hidalgo and Paula-Lima. Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low ...
    • The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated ... 
      Bruna, Bárbara; Lobos, Pedro; Herrera Molina, Rodrigo; Hidalgo Tapia, María Cecilia; Paula Lima, Andrea; Adasme, Tatiana (Elsevier B.V., 2018)
      © 2018 Elsevier Inc. The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. These pathways include ...