Browsing by Author "0418156a-7275-4110-90cb-8ede17d9e50f"

Now showing items 1-2 of 2

    • Genotoxic stress triggers the activation of IRE1 alpha-dependent RNA decay to modulate the DNA damage response 
      Dufey, Estefanie; Bravo San Pedro, José; Eggers Aracena, Cristián; González Quiroz, Matías; Urra Zúñiga, Hery; Sagredo Campos, Alfredo; Sepúlveda Alvarado, Denisse; Pihán Najle, Philippe; Carreras Sureda, Armando; Hazari, Younis; Sagredo, Eduardo A.; Gutiérrez, Daniela; Valls, Cristian; Papaioannou, Alexandra; Acosta Alvear, Diego; Campos, Gisela; Domingos, Pedro M.; Pedeux, Rémy; Chevet, Eric; Álvarez, Alejandra R.; Godoy, Patricio; Walter, Peter; Glavic Maurer, Álvaro; Kroemer, Guido; Hetz Flores, Claudio (Nature, 2020)
      The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1 ...
    • Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease 
      Campos, Gisela; Schmidt-Heck, Wolfgang; De Smedt, Jonathan; Widera, Agata; Ghallab, Ahmed; Puetter, Larissa; González, Daniela; Edlund, Karolina; Cadenas, Cristina; Marchan, Rosemarie; Guthke, Reinhard; Verfaillie, Catherine; Hetz Flores, Claudio; Sachinidis, Agapios; Braeuning, Albert; Schwarz, Michael; Weiss, Thomas S.; Banhart, Benjamin K.; Hoek, Jan; Vadigepalli, Rajanikanth; Willy, Jeffrey; Stevens, James L.; Hay, David C.; Hengstler, Jan G.; Godoy, Patricio (Springer, 2020)
      Inflammation has been recognized as essential for restorative regeneration. Here, we analyzed the sequential processes during onset of liver injury and subsequent regeneration based on time-resolved transcriptional regulatory ...