Browsing by Author "051becb5-ddbb-44d5-944f-544535385ade"

Now showing items 1-5 of 5

    • Cyclin - dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C - ... 
      Coddou, Claudio; Sandoval, Rodrigo; Castro, Patricio; Lazcano, Pablo; Hevia, María José; Rokic, Milos; Hall, Bradford; Terse, Anita; González Billault, Christian; Kulkarni, Ashok B.; Stojilkovic, Stanko S.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2017)
      The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size ...
    • Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice 
      Contreras Vallejos, Erick; Utreras Puratich, Elías; Bórquez, Daniel A.; Prochazkova, Michaela; Terse, Anita; Jaffe, Howard; Toledo, Andrea; Arruti, Cristina; Pant, Harish C.; Kulkarni, Ashok B.; González Billault, Christian (Public Library of Science, 2014)
      Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly ...
    • Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist ... 
      Utreras Puratich, Elías; Hamada, Ryusuke; Prochazkova, Michaela; Terse, Anita; Takahashi, Satoru; Ohshima, Toshio; Kulkarni, Ashok B. (BioMed Central Ltd., 2014)
      Background: Cyclin-dependent kinase 5 (Cdk5) is essential for brain development and function, and its deregulated expression is implicated in some of neurodegenerative diseases. We reported earlier that the forebrain-specific ...
    • Targeted overexpression of tumor necrosis factor-a increases cyclin-dependent kinase 5 activity and ... 
      Rozas, Pablo; Lazcano, Pablo; Piña, Ricardo; Cho, A.; Terse, Anita; Pertusa, María; Madrid, Rodolfo; González Billault, Christian; Kulkarni, Ashok B.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2016)
      We reported earlier that TNF-alpha, a proinflammatory cytokine implicated in many inflammatory disorders causing orofacial pain, increases the activity of Cdk5, a key kinase involved in brain development and function and ...
    • TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells 
      Utreras Puratich, Elías; Prochazkova, Michaela; Terse, Anita; Gross, Jacklyn; Keller, Jason; Iadarola, Michael J.; Kulkarni, Ashok B. (2013)
      Background: Odontoblasts are specialized cells that form dentin and they are believed to be sensors for tooth pain. Transforming growth factor-β1 (TGF-β1), a pro-inflammatory cytokine expressed early in odontoblasts, plays ...