Now showing items 1-4 of 4

    • Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones 

      Pagano, Mariana; Demoro, Bruno; Toloza, Jeannette; Boiani, Lucía; González, Mercedes; Cerecetto, Hugo; Olea Azar, Claudio; Norambuena, Ester; Gambino, Dinorah; Otero, Lucía (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      In the search of new therapeutic tools for the treatment of American Trypanosomiasis, the largest parasitic disease burden in the American continent, three series of novel ruthenium complexes of the formula [RuCl2(HL)(2)], ...
    • Ibandronate metal complexes: solution behavior and antiparasitic activity 

      Demoro, Bruno; Rostan, Santiago; Moncada, Mauricio; Li, Zhu Hong; Docampo, Roberto; Olea Azar, Claudio; Maya Arango, Juan; Torres, Julia; Gambino, Dinorah; Otero, Lucia (Springer, 2018)
      To face the high costs of developing new drugs, researchers in both industry and academy are looking for ways to repurpose old drugs for new uses. In this sense, bisphosphonates that are clinically used for bone diseases ...
    • New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents 

      Demoro, Bruno; Sarniguet, Cynthia; Sánchez Delgado, Roberto; Rossi, Miriam; Liebowitz, Daniel; Caruso, Francesco; Olea Azar, Claudio; Moreno, Virtudes; Medeiros, Andrea; Comini, Marcelo A.; Otero, Lucía; Gambino, Dinorah (ROYAL SOC CHEMISTRY, 2012)
      In the search for new therapeutic tools against neglected diseases produced by trypanosomatid parasites, and particularly against African Trypanosomiasis, whose etiological agent is Trypanosoma brucei, organoruthenium ...
    • Potential Mechanism of the Anti-trypanosomal Activity of Organoruthenium Complexes with Bioactive Thiosemicarbazones 

      Demoro, Bruno; Rossi, Miriam; Caruso, Francesco; Liebowitz, Daniel; Olea Azar, Claudio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Guiset, Helena; Moreno, Virtudes; Pizzo, Chiara; Mahler, Graciela; Otero, Lucía; Gambino, Dinorah (Springer, 2013)
      In the search for new metal-based drugs against diseases produced by trypanosomatid parasites, four organoruthenium(II) compounds [Ru2(p-cymene)2(L)2] X2, where L are bioactive 5-nitrofuryl-containing thiosemicarbazones ...