Browsing by Author "1281ce5c-62e0-438f-91be-e5c0b1316482"

Now showing items 1-13 of 13

    • 2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities 
      Sieveking, Ivan; Thomas, Pablo; Estévez, Juan C.; Quiñones, Natalia; Cuéllar, Mauricio A.; Villena, Juan; Espinosa Bustos, Christian; Fierro, Angélica; Tapia, Ricardo A.; Maya Arango, Juan; López Muñoz, Rodrigo; Cassels Niven, Bruce; Estévez, Ramón J.; Salas, Cristian (Elsevier, 2014)
      A series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited epimastigote growth and trypomastigote viability. ...
    • A convenient synthesis of benzo[g]pyrrolo[3,2-c]quinoline-6,11-diones 
      Tapia, Ricardo; López, Claudio; Morello Casté, Antonio; Maya Arango, Juan; Valderrama, Jaime (2005)
      The synthesis of a new class of angular tetracyclic quinones is described. Our strategy involves Diels-Alder reaction of pyrroloquinolinequinone 9, generated in situ from pyrroloquinoline 8, and dienes. The required ...
    • Adsorption behavior of hydrophobically modified polyelectrolytes onto amino- or methyl-terminated surfaces 
      Briones, Ximena G.; Encinas, María V.; Petri, Denise F.S.; Pavez, Jorge E.; Tapia, Ricardo A.; Yazdani-Pedram Zobeiri, Mehrdad; Urzúa Acevedo, Marcela (2011)
      The adsorption of hydrophobically modified polyelectrolytes derived from poly(maleic anhydride-alt-styrene) (P(MA-alt-St)) containing in their side chain aryl-alkyl groups onto amino- or methyl-terminated silicon wafers ...
    • Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting ... 
      Espinosa Bustos, Christian; Lagos, Carlos F.; Romero Parra, Javier; Zárate, Ana M.; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Iturriaga-Vásquez, Patricio; Tapia, Ricardo A.; Pessoa Mahana, Carlos David (Wiley-VCH Verlag, 2015)
      © 2015 Wiley-VCH Verlag GmbH & Co. KGaA. A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand ...
    • Effect of the nature of the nucleophile and solvent on an SNAr reaction 
      Gazitua, Marcela; Tapia, Ricardo A.; Contreras Ramos, Renato; Campodonico, Paola R. (Royal Society of Chemistry, 2018)
      The reaction of 2,4-dinitrobenzenesulfonyl chloride toward propylamine was kinetically evaluated in 19 organic solvents and 10 ionic liquids as reaction media. This study was compared with a previous study to experimentally ...
    • Gutmann's Donor Numbers Correctly Assess the Effect of the Solvent on the Kinetics of SNAr Reactions in ... 
      Alarcón Esposito, Jazmín; Contreras Ramos, Renato; Tapia, Ricardo A.; Campodónico, Paola R. (2016)
      We report an experimental study on the effect of solvents on the model SNAr reaction between 1-chloro-2,4dinitrobenzene and morpholine in a series of pure ionic liquids (IL). A significant catalytic effect is observed with ...
    • Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions ... 
      Lagos, Carlos F.; Araya Secchi, Raúl; Thomas, Pablo; Pérez-Acle, Tomás; Tapia, Ricardo A.; Salas, Cristian O. (2012)
      Trypanosoma cruzi glutamate cysteine ligase (TcGCL) is considered a potential drug target to develop novel antichagasic drugs. We have used a variety of computational methods to investigate the interactions between TcGCL ...
    • N-Heterocyclic carbene copper(I) complex-catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles 
      Urzua, Julio I.; Contreras Ramos, Renato; Salas, Cristian O.; Tapia, Ricardo A. (2016)
      A new and efficient synthesis of 2-arylbenzoxazoles and benzothiazoles using a copper N-heterocyclic carbene complex is described. In a simple protocol a variety of 2-substituted benzoxazoles and benzothiazoles were obtained ...
    • Natural and synthetic naphthoquinones active against Trypanosoma cruzi: An initial step towards new drugs ... 
      Salas, Cristian O.; Faúndez, Mario; Morello Casté, Antonio; Maya Arango, Juan; Tapia, Ricardo A. (2011)
      Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and benznidazole, are toxic and present severe side ...
    • Specific nucleophile-electrophile interactions in nucleophilic aromatic substitutions 
      Ormazábal Toledo, Rodrigo; Contreras Ramos, Renato; Tapia, Ricardo A.; Campodónico, Paola R. (2013)
      We herein report results obtained from an integrated experimental and theoretical study on aromatic nucleophilic substitution (SNAr) reactions of a series of amines towards 1-fluoro-2,4-dinitrobenzene in water. Specific ...
    • Synthesis and characterization of poly (ionic liquid) derivatives of N -alkyl quaternized poly (4-vinylpyridine) 
      Briones O., Ximena; Tapia, Ricardo A.; Campodonico, Paola R.; Urzúa Acevedo, Marcela; Leiva, Angel; Contreras Ramos, Renato; González Navarrete, Javier (Elsevier, 2018)
      The main motivation of this work is to obtain poly (ionic liquids) (PILs) derived from poly (4-vinyl pyridine) of different hydrophobic character containing BF4-, PF6-, (CF3SO2)(2) N- and CF3SO3- as counterions. PILs were ...
    • Synthesis and evaluation of the trypanocydal activity of 4- alkylamino-6-nitroquinolines 
      Tapia, Ricardo A.; Prieto, Yolanda; Zamora, Gaston; Morello Casté, Antonio; Repetto Scaramelli, Yolanda (Freund Publishing House Ltd, 2000)
      A straightforward synthesis of a group of 4-alkylamino-6-nitroquinolines starting from a common intermediate, 5,8-dimethoxy-6-nitro-4(1H)quinolone 3, is described. These compounds were tested in vitro as potential ...
    • Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents 
      Tapia, Ricardo A.; Carrasco, Claudia; Ojeda, Scarlet; Salas, Cristian; Valderrama, Jaime A.; Morello Casté, Antonio; Repetto Scaramelli, Yolanda (2002)
      The synthesis of new indazol-4,7-dione derivatives via 1,3-dipolar cycloaddition of diazomethane with 2,3-dimethyl-1,4-benzoquinone (2) and 1,4-naphthoquinone (7) followed by N-alkylation of the pyrazol nitrogen atom of ...