Browsing by Author "13f401ef-d05b-42fe-96e4-09ae0b11fe01"

Now showing items 1-8 of 8

    • Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle 
      Arias Calderón, Manuel; Almarza, Gonzalo; Díaz Vegas, Alexis; Contreras Ferrat, Ariel Eduardo; Valladares Ide, Denisse; Casas Atala, Mariana; Toledo Araya, Héctor; Jaimovich Pérez, Enrique; Buvinic Radic, Sonja (Biomed Central, 2016)
      Background: Electrical activity regulates the expression of skeletal muscle genes by a process known as “ excitation-transcription” (E-T) coupling. We have demonstrated that release of adenosine 5′-triphosphate (ATP) ...
    • Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion 
      Mizgier, María Luisa; Cataldo, Luis R.; Gutierrez, Juan; Santos, José Luis; Casas, Mariana; Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Moro, Cedric; Bouzakri, Karim; Galgani Fuentes, José (Hindawi Publishing Corporation, 2017)
      © 2017 Maria L. Mizgier et al. Fasting to postprandial transition requires a tight adjustment of insulin secretion to its demand, so tissue (e.g., skeletal muscle) glucose supply is assured while hypo-/hyperglycemia are ...
    • Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kg-Akt-AS160 in ... 
      Osorio Fuentealba, César; Contreras Ferrat, Ariel Eduardo; Altamirano, Francisco; Espinosa Escalona, Berta; Li, Qing; Niu, Wenyan; Lavandero González, Sergio; Klip, Amira; Jaimovich Pérez, Enrique (American Diabetes Association, 2013)
      Skeletal muscle glucose uptake in response to exercise is preserved in insulin-resistant conditions, but the signals involved are debated. ATP is released from skeletal muscle by contractile activity and can autocrinely ...
    • Fibroblast growth factor-21 potentiates glucose transport in skeletal muscle fibers 
      Rosales Soto, Giovanni; Díaz Vegas, Alexis; Casas Atala, Mariana; Contreras Ferrat, Ariel; Jaimovich Pérez, Enrique (Bioscientifica, 2020)
      Fibroblast growth factor 21 (FGF21) is a pleiotropic peptide hormone that is considered a myokine playing a role in a variety of endocrine functions, including regulation of glucose transport and lipid metabolism. Although ...
    • Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction 
      Wende, Adam R.; Schell, John C.; Ha, Chae-Myeong; Pepin, Mark E.; Khalimonchuk, Oleh; Schwertz, Hansjörg; Pereira, Renata O.; Brahma, Manoja K.; Tuinei, Joseph; Contreras Ferrat, Ariel Eduardo; Wang, Li; Andrizzi, Chase A.; Olsen, Curtis D.; Bradley, Wayne E.; Dell’Italia, Louis J.; Dillmann, Wolfgang H.; Litwin, Sheldon E.; Abel, E. Dale (American Diabetes Association, 2020)
      Cardiac glucose uptake and oxidation are reduced in diabetes despite hyperglycemia. Mitochondrial dysfunction contributes to heart failure in diabetes. It is unclear whether these changes are adaptive or maladaptive. To ...
    • Mitochondrial calcium increase induced by RyR1 and IP3R channel activation after membrane depolarization ... 
      Díaz Vegas, Alexis; Córdova, A.; Valladares, Denisse; Llanos Vidal, Paola; Hidalgo, C.; Gherardi, Gaia; Stefani, Diego De; Mammucari, Cristina; Rizzuto, Rosario; Contreras Ferrat, Ariel Eduardo; Jaimovich Pérez, Enrique (Frontiers Media, 2018-06)
      Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by ...
    • NOX2 Inhibition Impairs Early Muscle Gene Expression Induced by a Single Exercise Bout 
      Henríquez Olguín, Carlos; Díaz Vegas, Alexis; Utreras Mendoza, Yildy; Campos Acevedo, Cristian; Arias Calderón, Manuel; Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Espinosa Escalona, Alejandra; Altamirano, Francisco; Jaimovich Pérez, Enrique; Valladares Ide, Denisse (Frontiers Media, 2016)
      Reactive oxygen species (ROS) participate as signaling molecules in response to exercise in skeletal muscle. However, the source of ROS and the molecular mechanisms involved in these phenomena are still not completely ...
    • Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease 
      Bravo Sagua, Roberto; Parra Ortiz, Valentina; Muñoz Córdova, Felipe; Sánchez Aguilera, Pablo; Garrido, Valeria; Contreras Ferrat, Ariel; Chiong Lay, Mario; Lavandero González, Sergio (Elsevier, 2020)
      The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular ...