Browsing by Author "155f5579-5a6d-4c00-aa43-16c32d48dee9"
Now showing items 1-20 of 42
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ACE2 and vasoactive peptides: Novel players in cardiovascular/renal remodeling and hypertension
(2015)The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and homeostasis due to its influence on the regulation of electrolyte balance, blood pressure, vascular tone and cardiovascular remodeling. ... -
Actividad plasmática de la enzima convertidora de angiotensina I en población chilena normal y relación con el genotipo inserción/delección (I/D) de la enzima convertidora de angiotensina
(Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2000)El objetivo del estudio fue estimar la prevalencia de los distintos alelos del polimorfismo del gen de la enzima convertidora de angiotensina (ECA), inserción/deserción (I/D) y simultáneamente la actividad de ECA plasmática ... -
Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model
(LIPPINCOTT WILLIAMS & WILKINS, 2002-03)Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is ... -
Angiotensin I-converting enzyme insertion/delection polymorphism and adrenergic response to exercise in hypertensive patients
(International Medical Science for Experimental and Clinical Research, 2002)The insertion/delection ACE polymorphism (ACE I/D) regulates different levels of circulating and tissue ACE activities, which may induce diverse adrenergic responses to physiological stimuli. The aim of this study was ... -
Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat
(LIPPINCOTT WILLIAMS & WILKINS, 2001-09)Angiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were ... -
Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension
(Elsevier Inc., 2018)© 2018 Elsevier Inc. Hypertension-induced cardiovascular and renal damage can be mediated by activation of the renin-angiotensin-aldosterone system. There are different factors beyond renin-angiotensin-aldosterone system ... -
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro
(Lippincott Williams and Wilkins, 2010)Background: Angiotensin-(1-9) is present in human and rat plasma and its circulating levels increased early after myocardial infarction or in animals treated with angiotensin-converting enzyme inhibitor. However, the ... -
Blood pressure reduction, potassium channels, and the endothelium - Insights from L-serine
(LIPPINCOTT WILLIAMS & WILKINS, 2008-03) -
Changes in cyclic AMP dependent protein kinase and active stiffness in the rat volume overload model of heart hypertrophy
(Oxford University Press, 1993)Objective: The aim was to clarify the role of cyclic AMP dependent protein kinase (PKA) and changes in mechanical heart function during development of cardiac hypertrophy induced by volume overload. Methods: Protein and ... -
Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction
(Academic Press, 1996)The role of cyclic AMP-dependent protein kinase (PKA) and systolic function during the development of left ventricular hypertrophy (LVH) still remain uncertain. The aim of this work is to study PKA activity and mechanical ... -
Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism
(SAGE PUBLICATIONS LTD, 2008-09)Introduction. Isoproterenol treatment of Brown Norway Lewis rats (high and low plasma angiotersin-I-converting enzyme activity., respectively) results in similar cardiac hypertrophy but higher cardiac fibrosis in Brown ... -
Early prevention of experimental left ventricular hypertrophy in experimental hypertension and angiotensin II levels. Prevención precoz de hipertrofia ventricular izquierda en la hipertensión experimental y concentraciones de angiotensina II
(EDICIONES DOYMA S/L, 2001-11)Introduction. Angiotensin II levels can be partially inhibited during chronic administration of angiotensin converting enzyme (ACE) inhibitors, limiting from a clinical point of view its efficacy in the treatment of ... -
Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme polymorphism
(PERGAMON-ELSEVIER SCIENCE LTD, 2006-02-28)To determine circulating angiotensin-(1-7) [Ang-(1,7)] levels in rats with different angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension on levels of this heptapeptide, plasma levels ... -
Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat
(PERGAMON-ELSEVIER SCIENCE LTD, 1999-03-26)There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the ... -
Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study
(Elsevier, 2014)Objectives: Heart failure (HF) is associated with changes in myocardial metabolism that lead to impairment of contractile function. Trimetazidine (TMZ) modulates cardiac energetic efficiency and improves outcomes in ... -
Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
(LIPPINCOTT WILLIAMS & WILKINS, 2006-10)The early and long-term effects of coronary artery ligation on the plasma and left ventricular angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels, circulating angiotensin (Ang) levels [Ang ... -
Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels
(LIPPINCOTT WILLIAMS & WILKINS, 2005-12)In humans and rats, angiotensin I-converting enzyme activity is significantly determined by a gene polymorphism. Homozygous Brown Norway rats have higher plasma angiotensin I-converting enzyme activity and circulating ... -
Increased rho-kinase activity in hypertensive patients with left ventricular hypertrophy
(Oxford University Press, 2014)background There is experimental evidence on the role of Rho-kinase (ROCK) activation in cardiac hypertrophy but no information on its role in human hypertension and left ventricular hypertrophy (LVH). We hypothesized that ... -
Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica
(SOC MEDICA SANTIAGO, 2008-11)Background: beta adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostatis. Among these, beta(1) and beta(2) AR regulate cardiac contractility and frequency and are important ... -
Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis
(LIPPINCOTT WILLIAMS & WILKINS, 2002-08)This study investigated whether long-term administration of isoproterenol (ISO) induces differential expression of angiotensin-converting enzyme (ACE) in lung, plasma, and left ventricle (LV) during development of left ...
