Browsing by Author "155f5579-5a6d-4c00-aa43-16c32d48dee9"
Now showing items 1-20 of 46
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ACE2 and vasoactive peptides: Novel players in cardiovascular/renal remodeling and hypertension
Mendoza Torres, Evelyn; Oyarzún, Alejandra; Mondaca Ruff, David; Azocar, Andrés; Chiong Lay, Mario; Castro, Pablo F.; Jalil Milad, Jorge; Lavandero González, Sergio; Ocaranza, María Paz (2015)The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and homeostasis due to its influence on the regulation of electrolyte balance, blood pressure, vascular tone and cardiovascular remodeling. ... -
Actividad plasmática de la enzima convertidora de angiotensina I en población chilena normal y relación con el genotipo inserción/delección (I/D) de la enzima convertidora de angiotensina
Jalil Milad, Jorge; Córdova, Samuel; Piddo Mijares, Ana María; Chamorro, Gastón; Braun J., Sandra; Vega, Jeanette; Jadue, Liliana; Lavandero González, Sergio; Jalil R., R.; Lastra, P.; Garrido, Carmen (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2000)El objetivo del estudio fue estimar la prevalencia de los distintos alelos del polimorfismo del gen de la enzima convertidora de angiotensina (ECA), inserción/deserción (I/D) y simultáneamente la actividad de ECA plasmática ... -
Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model
Ocaranza, María Paz; Piddo Mijares, Ana María; Faúndez Fuentes, Perla Andrea; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2002-03)Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is ... -
Angiotensin I-converting enzyme insertion/delection polymorphism and adrenergic response to exercise in hypertensive patients
Jalil Milad, Jorge; Córdova, Samuel; Ocaranza, María Paz; Schumacher, Erwin; Braun J., Sandra; Chamorro, Gastón; Fardella, Carlos E.; Lavandero González, Sergio (International Medical Science for Experimental and Clinical Research, 2002)The insertion/delection ACE polymorphism (ACE I/D) regulates different levels of circulating and tissue ACE activities, which may induce diverse adrenergic responses to physiological stimuli. The aim of this study was ... -
Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat
Oliveri Pérez, Carla Giovanna; Ocaranza, María Paz; Campos Bastidas, Ximena; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2001-09)Angiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were ... -
Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension
González, Leticia; Novoa, Ulises; Moya, Jackeline; Gabrielli, Luigi; Jalil Milad, Jorge; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Ocaranza, María Paz (Elsevier Inc., 2018)© 2018 Elsevier Inc. Hypertension-induced cardiovascular and renal damage can be mediated by activation of the renin-angiotensin-aldosterone system. There are different factors beyond renin-angiotensin-aldosterone system ... -
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro
Ocaranza, Maria Paz; Lavandero González, Sergio; Jalil Milad, Jorge; Moya, Jaqueline; Pinto, Melissa; Novoa, Ulises; Apablaza, Felipe; González, Leticia; Hernández, Carol; Varas, Manuel; López, René; Godoy, Iván; Verdejo, Hugo; Chiong Lay, Mario (Lippincott Williams and Wilkins, 2010)Background: Angiotensin-(1-9) is present in human and rat plasma and its circulating levels increased early after myocardial infarction or in animals treated with angiotensin-converting enzyme inhibitor. However, the ... -
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolás; García Nannig, Lorena; Novoa, Ulises; Ayala, Pedro; Díaz Araya, Guillermo; Godoy, Ivan; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Lippincott Williams and Wilkins, 2014)BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: ... -
Blood pressure reduction, potassium channels, and the endothelium - Insights from L-serine
Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2008-03) -
Changes in cyclic AMP dependent protein kinase and active stiffness in the rat volume overload model of heart hypertrophy
Lavandero González, Sergio; Cartagena, Gastón; Guarda, Eduardo; Corbalán, Ramón; Godoy, Iván; Sapag Hagar, Mario; Jalil Milad, Jorge (Oxford University Press, 1993)Objective: The aim was to clarify the role of cyclic AMP dependent protein kinase (PKA) and changes in mechanical heart function during development of cardiac hypertrophy induced by volume overload. Methods: Protein and ... -
Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction
Piddo Mijares, Ana María; Sánchez, María Isabel; Sapag Hagar, Mario; Corbalán, Ramón; Foncea, Rocío; Ebensperger González, Roberto; Godoy, Iván; Meléndez, Jaime; Jalil Milad, Jorge; Lavandero González, Sergio (Academic Press, 1996)The role of cyclic AMP-dependent protein kinase (PKA) and systolic function during the development of left ventricular hypertrophy (LVH) still remain uncertain. The aim of this work is to study PKA activity and mechanical ... -
Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism
Copaja Soto, Miguel; Valenzuela, Rodrigo; Saldaña, Adiela; Ocaranza, María Paz; Jalil Milad, Jorge; Vio, Carlos; Lijnen, Paul; Ordenes, Gamaliel; Vivar Sánchez, Raúl; Lavandero González, Sergio; Díaz Araya, Guillermo (SAGE PUBLICATIONS LTD, 2008-09)Introduction. Isoproterenol treatment of Brown Norway Lewis rats (high and low plasma angiotersin-I-converting enzyme activity., respectively) results in similar cardiac hypertrophy but higher cardiac fibrosis in Brown ... -
Early prevention of experimental left ventricular hypertrophy in experimental hypertension and angiotensin II levels. Prevención precoz de hipertrofia ventricular izquierda en la hipertensión experimental y concentraciones de angiotensina II
Gálvez, Anita; Ocaranza, María Paz; Lavandero González, Sergio; Jalil Milad, Jorge (EDICIONES DOYMA S/L, 2001-11)Introduction. Angiotensin II levels can be partially inhibited during chronic administration of angiotensin converting enzyme (ACE) inhibitors, limiting from a clinical point of view its efficacy in the treatment of ... -
Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme polymorphism
Ocaranza, María Paz; Palomera, Cristián; Román, Maritza; Bargetto, Jorge; Lavandero González, Sergio; Jalil Milad, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2006-02-28)To determine circulating angiotensin-(1-7) [Ang-(1,7)] levels in rats with different angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension on levels of this heptapeptide, plasma levels ... -
Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat
Jalil Milad, Jorge; Ebensperger González, Roberto; Meléndez Vergara, Jaime; Acevedo, E.; Sapag Hagar, Mario; González Jara, Fabián Rodrigo; Gálvez, Anita; Pérez Montes, Viviana; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 1999-03-26)There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the ... -
Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study
Winter, José Luis; Castro, Pablo F.; Quintana, Juan Carlos; Altamirano, Rodrigo; Enriquez, Andrés; Verdejo, Hugo E.; Jalil Milad, Jorge; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda, Pablo; Rossel Mariangel, Víctor Alejandro; Sepúlveda Morales, Luis; Chiong Lay, Mario; García Nannig, Lorena; Lavandero González, Sergio (Elsevier, 2014)Objectives: Heart failure (HF) is associated with changes in myocardial metabolism that lead to impairment of contractile function. Trimetazidine (TMZ) modulates cardiac energetic efficiency and improves outcomes in ... -
Elevated Systemic Inflammatory Burden and Cardiovascular Risk in Young Adults with Endodontic Apical Lesions
Garrido, Mauricio; Cárdenas, Angélica M.; Astorga, Jessica; Quinlan, Francisca; Valdés, Macarena; Chaparro, Alejandra; Carvajal, Paola; Pussinen, Pirkko; Huamán-Chipana, Patricia; Jalil Milad, Jorge; Hernández, Marcela (Elsevier Inc., 2019)Introduction: The aim of this study was to assess whether apical lesions are associated with inflammatory serum markers of cardiovascular risk, especially high-sensitivity C-reactive protein (hsCRP), in young adults. ... -
Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
Ocaranza, María Paz; Godoy, Iván; Jalil Milad, Jorge; Varas, Manuel; Collantes, Patricia; Pinto, Melissa; Román, Maritza; Ramírez, Cristián; Copaja, Miguel; Díaz Araya, Guillermo; Castro, Pablo; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2006-10)The early and long-term effects of coronary artery ligation on the plasma and left ventricular angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels, circulating angiotensin (Ang) levels [Ang ... -
Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels
Jalil Milad, Jorge; Pérez, Alfonso; Ocaranza, María Paz; Bargetto, Jorge; Galaz, Alfonso; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2005-12)In humans and rats, angiotensin I-converting enzyme activity is significantly determined by a gene polymorphism. Homozygous Brown Norway rats have higher plasma angiotensin I-converting enzyme activity and circulating ... -
Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary aldosteronism patients
Stehr, Carlos B.; Mellado, Rosemarie; Ocaranza, Maria P.; Carvajal, Cristian A.; Mosso, Lorena; Becerra, Elia; Solis, Margarita; García Nannig, Lorena; Lavandero González, Sergio; Jalil Milad, Jorge; Fardella, Carlos E. (2010)Background: Patients with primary aldosteronism experience greater left ventricular hypertrophy and a higher frequency of cardiovascular events than do essential hypertensive patients with comparable blood pressure levels. ...