Browsing by Author "17fda07f-f2f5-42f0-945d-d419396b4ecc"

Now showing items 1-9 of 9

    • Cdk5 regulates Rap1 activity 
      Utreras Puratich, Elías; Henríquez, Daniel R.; Contreras Vallejos, Erick; Olmos, Cristina; Di Genova, Alex; Maass Sepúlveda, Alejandro; Kulkarni, Ashok B.; González Billault, Christian (2013)
      Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such ...
    • Cyclin - dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C - ... 
      Coddou, Claudio; Sandoval, Rodrigo; Castro, Patricio; Lazcano, Pablo; Hevia, María José; Rokic, Milos; Hall, Bradford; Terse, Anita; González Billault, Christian; Kulkarni, Ashok B.; Stojilkovic, Stanko S.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2017)
      The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size ...
    • Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction ... 
      Maldonado, Horacio; Ramírez, Eugenio; Utreras Puratich, Elías; Pando, María E.; Kettlun, Ana M.; Chiong Lay, Mario; Kulkarni, Ashok B.; Collados, Lucía; Puente, Javier; Cartier Rovirosa, Luis; Valenzuela, María A. (2011)
      Human T-cell leukemia virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease characterized by selective loss of axons and myelin in the corticospinal tracts. This ...
    • Regulation of Sox6 by cyclin dependent kinase 5 in brain 
      Rudrabhatla, Parvathi; Utreras Puratich, Elías; Jaffe, Howard; Kulkarni, Ashok B. (Public Library of Science, 2014)
      Cyclin dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase involved in various biological functions during normal brain development and neurodegeneration. In brain, Cdk5 activity is specific to post-mitotic ...
    • Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice 
      Contreras Vallejos, Erick; Utreras Puratich, Elías; Bórquez, Daniel A.; Prochazkova, Michaela; Terse, Anita; Jaffe, Howard; Toledo, Andrea; Arruti, Cristina; Pant, Harish C.; Kulkarni, Ashok B.; González Billault, Christian (Public Library of Science, 2014)
      Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly ...
    • Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist ... 
      Utreras Puratich, Elías; Hamada, Ryusuke; Prochazkova, Michaela; Terse, Anita; Takahashi, Satoru; Ohshima, Toshio; Kulkarni, Ashok B. (BioMed Central Ltd., 2014)
      Background: Cyclin-dependent kinase 5 (Cdk5) is essential for brain development and function, and its deregulated expression is implicated in some of neurodegenerative diseases. We reported earlier that the forebrain-specific ...
    • Targeted overexpression of tumor necrosis factor-a increases cyclin-dependent kinase 5 activity and ... 
      Rozas, Pablo; Lazcano, Pablo; Piña, Ricardo; Cho, A.; Terse, Anita; Pertusa, María; Madrid, Rodolfo; González Billault, Christian; Kulkarni, Ashok B.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2016)
      We reported earlier that TNF-alpha, a proinflammatory cytokine implicated in many inflammatory disorders causing orofacial pain, increases the activity of Cdk5, a key kinase involved in brain development and function and ...
    • TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells 
      Utreras Puratich, Elías; Prochazkova, Michaela; Terse, Anita; Gross, Jacklyn; Keller, Jason; Iadarola, Michael J.; Kulkarni, Ashok B. (2013)
      Background: Odontoblasts are specialized cells that form dentin and they are believed to be sensors for tooth pain. Transforming growth factor-β1 (TGF-β1), a pro-inflammatory cytokine expressed early in odontoblasts, plays ...
    • Transgenic mouse overexpressing EAAT3 (neuronal glutamate transporter): a novel genetic model of ... 
      Moya, Pablo; Delgado, Claudia; Cisternas, Marisol; Henriquez, Francisca; Gómez, Isabel; Utreras Puratich, Elías; Wendland, Jens; Kulkarni, Ashok; Murphy, Dennis (Elsevier, 2017)