Now showing items 1-20 of 116

    • A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion 

      Díaz, Jorge; Mendoza, Pablo; Silva, Patricio; Quest, Andrew F. G.; Torres, Vicente A. (Landes Bioscience, 2014)
      © Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has ...
    • Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells 

      Ehrenfeld, Pamela; Conejeros, Iván; Pavicic, María F.; Matus, Carola E.; González, Carlos B.; Quest, Andrew F. G.; Bhoola, Kanti D.; Poblete, María T.; Burgos, Rafael A.; Figueroa, Carlos D. (Elsevier, 2011)
      The kinin B1 receptor (B1R) agonist Lys-des[Arg9]-bradykinin (LDBK) increases proliferation of estrogen-sensitive breast cancer cells by a process involving activation of the epidermal growth factor receptor (EGFR) and ...
    • Age-dependent increases in apoptosis/necrosis ratios in human lymphocytes exposed to oxidative stress 

      Behrens, Maria I.; Silva, Monica; Schmied, Astrid; Salech, Felipe; Manzur, Hachi; Rebolledo, Rolando; Bull Simpfendorfer, Ricardo; Torres, Vicente; Henríquez, Mauricio; Quest, Andrew F. G. (2011)
      Unlike apoptosis, mechanisms leading to necrosis are less well understood. Moreover, changes in necrosis as a function of age have not been studied in human lymphocytes. H 2O 2-induced death of peripheral lymphocytes (56 ...
    • Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes 

      Ávalos, Ana María; Arthur, William T.; Schneider, Pascal; Quest, Andrew F. G.; Burridge, Keith; Leyton Campos, Lisette (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-09-10)
      Thy-1, a cell adhesion molecule abundantly expressed in mammalian neurons, binds to a beta(3)-containing integrin on astrocytes and thereby stimulates the assembly of focal adhesions and stress fibers. Such events lead to ...
    • alpha (V) beta (3) Integrin regulates astrocyte reactivity 

      Lagos Cabre, Raúl; Álvarez, Álvaro; Kong, Milene; Burgos Bravo, Francesca; Cárdenas, Areli; Rojas Mancilla, Edgardo; Pérez Núñez, Ramón; Herrera Molina, Rodrigo; Rojas, Fabiola; Schneider, Pascal; Herrera-Marschitz Muller, Mario; Quest, Andrew F. G.; van Zundert, Brigitte; Leyton Campos, Lisette (BIOMED Central Ltd., 2017)
      Background: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging alpha(V)beta(3) Integrin and Syndecan-4. Primary astrocytes express ...
    • alpha(V)beta(3) Integrin regulates astrocyte reactivity 

      Lagos Cabre, Raúl; Álvarez Martínez, Alvaro; Kong Rojas, Milene; Burgos Bravo, Francesca; Cárdenas Oyarzo, Areli; Rojas Mancilla, Edgardo; Pérez Núñez, Ramón; Herrera Molina, Rodrigo; Rojas, Fabiola; Schneider, Pascal; Herrera Marschitz, Mario; Quest, Andrew F. G.; van Zundert, Brigitte; Leyton Campos, Lisette (BMC, 2017)
      Background: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging alpha(V)beta(3) Integrin and Syndecan-4. Primary astrocytes express ...
    • Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of Patients With Sjögren’s Syndrome 

      González, Sergio; Aguilera, Sergio; Alliende, Cecilia; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Herrera Cisterna, Luisa; Molina, Claudio; Hermoso Ramello, Marcela; Ewert, Patricia; Brito, Mónica; Romo, Rafael; Leyton Martínez, Cecilia; Pérez, Paola; González Burgos, María Julieta (2011-04)
      Objective. Acinar cells in the salivary glands of patients with Sjo¨gren’s syndrome (SS) display severe alterations in anchorage to the basal lamina. Bioinformatics analysis of the BP230 gene sequence has revealed the ...
    • Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients 

      Lagos, Carolina; Carvajal, Patricia; Castro, Isabel; Jara, Daniela; González, Sergio; Aguilera, Sergio; Barrera, María José; Quest, Andrew F. G.; Bahamondes, Verónica; Molina, Claudio; Urzúa, Ulises; Hermoso Ramello, Marcela; Leyton, Cecilia; González Burgos, María Julieta (Academic Press Inc., 2018)
      © 2018 Elsevier Inc.Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial ...
    • Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway 

      Maldonado, H.; Calderon, C.; Burgos Bravo, Francesca; Kobler, Oliver; Zuschratter, W.; Ramirez, O.; Härtel, S.; Schneider, P.; Quest, Andrew F. G.; Herrera-Molina, R.; Leyton, L. (Elsevier B.V., 2017)
      © 2016 Elsevier B.V. Two key proteins for cellular communication between astrocytes and neurons are αvβ3 integrin and the receptor Thy-1. Binding of these molecules in the same (cis) or on adjacent (trans) cellular membranes ...
    • Astrocytic α vβ 3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering thy-1 

      Herrera Molina, Rodrigo; Frischknecht, Renato; Maldonado, Horacio; Seidenbecher, Constanze I.; Gundelfinger, Eckart D.; Hetz Flores, Claudio; Aylwin Ostale, María de la Luz; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2012)
      Thy-1 is a membrane glycoprotein suggested to stabilize or inhibit growth of neuronal processes. However, its precise function has remained obscure, because its endogenous ligand is unknown. We previously showed that Thy-1 ...
    • ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation 

      Henríquez, Mauricio; Herrera Molina, Rodrigo; Valdivia, Alejandra; Alvarez, Alvaro; Kong, Milene; Muñoz, Nicolás; Eisner, Verónica; Jaimovich Pérez, Enrique; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2011)
      Thy-1, an abundant mammalian glycoprotein, interacts with avβ3 integrin and syndecan-4 in astrocytes and thus triggers signaling events that involve RhoA and its effector p160ROCK, thereby increasing astrocyte adhesion to ...
    • Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state? 

      Peña Oyarzún, Daniel; Bravo Sagua, Roberto; Díaz Vega, Alexis; Aleman, Larissa; Chiong Lay, Mario; Garcia, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F. G.; Criollo Céspedes, Alfredo; Lavandero González, Sergio (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; ...
    • Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging 

      Díaz García, Víctor; Guerrero, Simón; Díaz Valdivia, Natalia; Lobos González, Lorena; Kogan Bocian, Marcelo; Pérez Donoso, José; Quest, Andrew F. G. (NLM (Medline), 2018)
      Background: Numerous studies have proposed the use of fluorescent semiconductor nanoparticles or quantum dots (QDs) as novel tools to label cells and tumors. However, QD applications are limited by their toxicity in ...
    • Biomimetic, Mild Chemical Synthesis of CdTe-GSH Quantum Dots with Improved Biocompatibility 

      Pérez Donoso, José; Monrás, Juan P.; Bravo, Denisse; Aguirre, Adam; Quest, Andrew F. G.; Osorio Román, Igor; Aroca, Ricardo F.; Chasteen, Thomas G.; Vásquez, Claudio C. (2012)
      Multiple applications of nanotechnology, especially those involving highly fluorescent nanoparticles (NPs) or quantum dots (QDs) have stimulated the research to develop simple, rapid and environmentally friendly protocols ...
    • Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death 

      Parra, Valentina; Moraga, Francisco; Kuzmicic, Jovan; López Crisosto, Camila; Troncoso, Rodrigo; Torrealba, Natalia; Criollo Céspedes, Alfredo; Díaz Elizondo, Jessica; Rothermel, Beverly A.; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2013)
      Ceramides are important intermediates in the biosynthesis and degradation of sphingolipids that regulatenumerous cellular processes, including cell cycle progression, cell growth, differentiation and death. In ...
    • Calcium transport and signaling in mitochondria 

      Bravo Sagua, Roberto; Parra Ortíz, María Valentina; López Crisosto, Camila; Díaz, Paula; Quest, Andrew F. G.; Lavandero González, Sergio (Wiley, 2017-04)
      Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell survival and death decisions. Given their ...
    • Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription 

      Tapia Pineda, Julio; Torres Gómez, Vicente; Rodríguez, D. A.; Leyton Campos, Lisette; Quest, Andrew F. G. (NATL ACAD SCIENCES, 2006-10-10)
      Increased expression of casein kinase 2 (CK2) is associated with hyperproliferation and suppression of apoptosis in cancer. Mutations in the tumor suppressor APC (adenomatous polyposis coli) are frequent in colon cancer ...
    • Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription 

      Tapia,; Torres,; Rodriguez,; Leyton,; Quest, Andrew F. G. (2006)
      Increased expression of casein kinase 2 (CK2) is associated with hyperproliferation and suppression of apoptosis in cancer. Mutations in the tumor suppressor APC (adenomatous polyposis coli) are frequent in colon cancer ...
    • Caveolae and caveolae-like membrane domains in cellular signaling and disease: Identification of downstream targets for the tumor suppressor protein caveolin-1 

      Bender, Florent; Montoya, Margarita; Monardes, Virginia; Leyton Campos, Lisette; Quest, Andrew F. G. (Society of Biology of Chile, 2002)
      Caveolae are small, flask-shaped invaginations of the plasma membrane present on a large number of mammalian cells. Recent results obtained with knock-out mice for the gene caveolin-1 demonstrate that expression of caveolin-1 ...
    • Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin 

      Torres Gómez, Vicente; Tapia Pineda, Julio; Rodríguez, Diego A.; Leyton Campos, Lisette; Párraga, Mario; Lisboa, Pamela; Montoya, Margarita; Quest, Andrew F. G. (COMPANY OF BIOLOGISTS LTD, 2006-05-01)
      Caveolin-1 is suggested to act as a tumor suppressor. We tested the hypothesis that caveolin-1 does so by repression of survivin, an Inhibitor of apoptosis protein that regulates cell-cycle progression as well as apoptosis ...