Browsing by Author "1a3c6b39-25c3-47d6-8eed-3a5ec8ab9733"

Now showing items 1-8 of 8

    • A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells ... 
      Gleisner Muñoz, María Alejandra; Pereda Ramos, Cristián; Tittarelli Elaskar, Andrés; Navarrete Sánchez, Mariela; Fuentes Villegas, Camila; Ávalos, Ignacio; Tempio Sepúlveda, Fabián; Araya, Juan Pablo; Becker, María Inés; González Bergas, Fermín; López Nitsche, Mercedes; Salazar Onfray, Flavio (BMJ, 2020)
      Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance to treatment, motivating the exploration of ...
    • Comparative EST transcript profiling of peach fruits under different post-harvest conditions reveals candidate ... 
      Vizoso, Paula; Meisel, Lee A.; Tittarelli, Andrés; Latorre, Mariano; Saba, Juan; Caroca, Rodrigo; Maldonado, Jonathan; Cambiazo Ayala, Verónica; Campos Vargas, Reinaldo; González, Mauricio; Orellana, Ariel; Silva Ascencio, Herman (2009)
      Background: Cold storage is used to inhibit peach fruit ripening during shipment to distant markets. However, this cold storage can negatively affect the quality of the fruit when it is ripened, resulting in disorders ...
    • Connexin-Mediated Signaling at the Immunological Synapse 
      Tittarelli, Andrés; Navarrete, Mariela; Gleisner, María Alejandra; Gebicke Härter, Peter; Salazar Onfray, Flavio (MDPI, 2020)
      The immunological synapse (IS) is an intercellular communication platform, organized at the contact site of two adjacent cells, where at least one is an immune cell. Functional IS formation is fundamental for the modulation ...
    • Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory ... 
      Falcón Beas, Cristián; Tittarelli, Andrés; Mora-Bau, Gabriela; Tempio, Fabián; Pérez Núñez, Claudio; Hevia, Daniel; Behrens, Carolina; Flores, Iván; Falcón-Beas, Felipe; Garrido, Paola; Ascui, Gabriel; Pereda, Cristián; González, Fermín E.; Salazar Onfray, Flavio; López, Mer (Elsevier GmbH, 2019)
      Background: Dendritic cells (DCs) are usually immunogenic, but they are also capable of inducing tolerance under anti-inflammatory conditions. Immunotherapy based on autologous DCs loaded with an allogeneic melanoma cell ...
    • Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation 
      Mendoza Naranjo, Ariadna; Bouma, Gerben; Pereda, Cristián; Ramiŕez, Marcos; Webb, Kevin F.; Tittarelli, Andrés; Loṕez, Mercedes N.; Kalergis, Alexis M.; Thrasher, Adrian J.; Becker, David L.; Salazar Onfray, Flavio (2011)
      Gap junction (GJ) mediates intercellular communication through linked hemichannels from each of two adjacent cells. Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune system, ...
    • Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 ... 
      Tittarelli, Andrés; Navarrete, Mariela; Lizana, Marcelo; Hofmann Vega, Francisca; Salazar Onfray, Flavio (MDPI, 2020)
      Alterations in microRNA (miRNA) profiles, induced by tumor microenvironment stressors, like hypoxia, allow cancer cells to acquire immune-resistance phenotypes. Indeed, hypoxia-induced miRNAs have been implicated in cancer ...
    • Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes ... 
      Tittarelli, Andrés; González, Fermín E.; Pereda, Cristián; Mora, Gabriela; Muñoz, Leonel; Saffie, Carlos; García, Tamara; Díaz, David; Falcón, Cristián; Hermoso, Marcela; López, Mercedes N.; Salazar Onfray, Flavio (2012)
      Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs ...
    • Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer 
      Rojas-Sepúlveda, Daniel; Tittarelli, Andrés; Gleisner, María Alejandra; Ávalos, Ignacio; Pereda, Cristián; Gallegos, Iván; González, Fermín Eduardo; López, Mercedes Natalia; Butte, Jean Michel; Roa, Juan; Fluxá, Paula; Salazar Onfray, Flavio (Springer Science and Business Media Deutschland GmbH, 2018)
      © 2018, The Author(s). Immunotherapy based on checkpoint blockers has proven survival benefits in patients with melanoma and other malignancies. Nevertheless, a significant proportion of treated patients remains refractory, ...