Now showing items 1-13 of 13

    • Comparative EST transcript profiling of peach fruits under different post-harvest conditions reveals candidate genes associated with peach fruit quality 

      Vizoso, Paula; Meisel, Lee A.; Tittarelli, Andrés; Latorre, Mariano; Saba, Juan; Caroca, Rodrigo; Maldonado, Jonathan; Cambiazo Ayala, Verónica; Campos Vargas, Reinaldo; González, Mauricio; Orellana, Ariel; Silva Ascencio, Herman (2009)
      Background: Cold storage is used to inhibit peach fruit ripening during shipment to distant markets. However, this cold storage can negatively affect the quality of the fruit when it is ripened, resulting in disorders ...
    • Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation 

      Mendoza Naranjo, Ariadna; Bouma, Gerben; Pereda, Cristián; Ramiŕez, Marcos; Webb, Kevin F.; Tittarelli, Andrés; Loṕez, Mercedes N.; Kalergis, Alexis M.; Thrasher, Adrian J.; Becker, David L.; Salazar Onfray, Flavio (2011)
      Gap junction (GJ) mediates intercellular communication through linked hemichannels from each of two adjacent cells. Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune system, ...
    • Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity 

      Tittarelli, Andrés; Mendoza Naranjo, Ariadna; Farías, Marcela; Guerrero, Israel; Ihara, Fumitaka; Wennerberg, Erik; Riquelme, Sebastián; Gleisner, Alejandra; Kalergis, Alexis; Lundqvist, Andreas; López Nitsche, Mercedes; Chambers, Benedict J.; Salazar Onfray, Flavio (The American Association of Immunologists, 2014)
      Gap junctions (GJs) mediate intercellular communication between adjacent cells. Previously, we showed that connexin 43 (Cx43), the main GJ protein in the immune system, mediates Ag transfer between human dendritic cells ...
    • Heat-Shock Induction of Tumor-Derived Danger Signals Mediates Rapid Monocyte Differentiation into Clinically Effective Dendritic Cells 

      Aguilera, Raquel; Saffie, Carlos; Tittarelli, Andrés; González Bergas, Fermín; Ramírez Fernández, Marcos; Reyes, Diego; Pereda, Cristián; Hevia, Daniel; García, Tamara; Salazar, Lorena; Ferreira Vigouroux, Luis Arturo; Hermoso Ramello, Marcela; Mendoza Naranjo, Ariadna; Ferrada, Carlos; Garrido, Paola; López Nitsche, Mercedes; Salazar Onfray, Flavio (AMER ASSOC CANCER RESEARCH, 2011-04-15)
      Purpose: This study characterizes, biologically and clinically, a novel type of dendritic cells (DC) produced in the short term and called tumor antigen–presenting cells (TAPCells). In particular, we identified factors ...
    • High CD8(+) and absence of Foxp3(+) T lymphocytes infiltration in gallbladder tumors correlate with prolonged patients survival 

      Fluxá Rojas, Paula; Rojas Sepúlveda, Daniel; Gleisner, María Alejandra; Tittarelli, Andrés; Villegas, Pablo; Tapia, Loreto; Rivera, María Teresa; López Nitsche, Mercedes; Catán, Felipe; Uribe Maturana, Mario; Salazar Onfray, Flavio (BIOMED Central Ltd., 2018)
      Background: Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only ...
    • High CD8+ and absence of Foxp3+ T lymphocytes infiltration in gallbladder tumors correlate with prolonged patients survival 

      Fluxá Rojas, Paula; Rojas Sepúlveda, Daniel; Gleisner Muñoz, María Alejandra; Tittarelli, Andrés; Villegas, Pablo; Tapia, Loreto; Rivera, María Teresa; López, Mercedes Natalia; Catán, Felipe; Uribe, Mario; Salazar Onfray, Flavio (BioMed Central Ltd., 2018)
      © 2018 The Author(s). Background: Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. ...
    • The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated with increased Th1/Th17 and reduced Th3 cytokine responses 

      Durán Aniotz, Claudia; Segal, Gabriela; Salazar, Lorena; Pereda, Cristián; Falcón, Cristián; Tempio, Fabián; Aguilera, Raquel; González González, Rodrigo; Pérez Núñez, Claudio; Tittarelli, Andrés; Catalán Martina, Diego; Nervi, Bruno; Larrondo Lillo, Milton; Salazar Onfray, Flavio; López Nitsche, Mercedes (Springer, 2013)
      Introduction Immunization with autologous dendritic cells (DCs) loaded with a heat shock-conditioned allogeneic melanoma cell lysate caused lysate-specific delayed type hypersensitivity (DTH) reactions in a number ...
    • Mind the gaps in tumor immunity: impact of connexin mediated intercellular connections 

      Gleisner, María Alejandra; Navarrete, Mariela; Hofmann, Francisca; Salazar Onfray, Flavio; Tittarelli, Andrés (Frontiers media SA, 2017)
      Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-formed plasma membrane channels that allow for the passage of small molecules between adjacent cells, and are involved in several ...
    • Molecular signatures associated with tumor-specific immune response in melanoma patients treated with dendritic cell-based immunotherapy 

      García-Salum, Tamara; Villablanca, Andrea; Matthäus, Franziska; Tittarelli, Andrés; Baeza, Mauricio; Pereda, Cristián; Gleisner Muñoz, María Alejandra; González, Fermín E.; López, Mercedes N.; Hoheisel, Jörg D.; Norgauer, Johannes; Gebicke Haerter, Peter J.; Salazar Onfray, Flavio (Impact Journals LLC, 2018)
      © García-Salum et al. Purpose: We previously showed that autologous dendritic cells (DCs) loaded with an allogeneic heat shock (HS)-conditioned melanoma cell-derived lysate, called TRIMEL, induce T-cell-mediated immune ...
    • Proteomic identification of heat shock induced danger signals in a melanoma cell lysate used in dendritic cell based cancer immunotherapy 

      González, Fermin E.; Chernobrovkin, Alexey; Pereda, Cristián; García Salum, Tamara; López, Mercedes N.; Salazar Onfray, Flavio; Zubarev, Roman A.; Tittarelli, Andrés (Hindawi Ltda., 2018)
      Autologous dendritic cells (DCs) loaded with cancer cell-derived lysates have become a promising tool in cancer immunotherapy. During the last decade, we demonstrated that vaccination of advanced melanoma patients with ...
    • Proteomic identification of heat shock-induced danger signals in a melanoma cell lysate used in dendritic cell-based cancer immunotherapy 

      González, Fermín E.; Chernobrovkin, Alexey; Pereda, Cristián; García-Salum, Tamara; Tittarelli, Andrés; López, Mercedes N.; Salazar Onfray, Flavio; Roman, A. (Hindawi Limited, 2018)
      Copyright © 2018 Fermín E. González et al. Autologous dendritic cells (DCs) loaded with cancer cell-derived lysates have become a promising tool in cancer immunotherapy. During the last decade, we demonstrated that vaccination ...
    • Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients 

      Tittarelli, Andrés; González, Fermín E.; Pereda, Cristián; Mora, Gabriela; Muñoz, Leonel; Saffie, Carlos; García, Tamara; Díaz, David; Falcón, Cristián; Hermoso, Marcela; López, Mercedes N.; Salazar Onfray, Flavio (2012)
      Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs ...
    • Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer 

      Rojas-Sepúlveda, Daniel; Tittarelli, Andrés; Gleisner, María Alejandra; Ávalos, Ignacio; Pereda, Cristián; Gallegos, Iván; González, Fermín Eduardo; López, Mercedes Natalia; Butte, Jean Michel; Roa, Juan; Fluxá, Paula; Salazar Onfray, Flavio (Springer Science and Business Media Deutschland GmbH, 2018)
      © 2018, The Author(s). Immunotherapy based on checkpoint blockers has proven survival benefits in patients with melanoma and other malignancies. Nevertheless, a significant proportion of treated patients remains refractory, ...