Now showing items 1-12 of 12

    • A BK (Slo1) channel journey from molecule to physiology 

      Contreras, Gustavo F.; Castillo, Karen; Enrique, Nicolás; Carrasquel Ursulaez, Willy; Castillo, Juan Pablo; Milesi, Verónica; Neely, Alan; Alvarez, Osvaldo; Ferreira, Gonzalo; Gonzalez, Carlos; Latorre, Ramón (Taylor and Francis Inc., 2013)
      Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and non-neuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK ...
    • Amyotrophic lateral sclerosis pathogenesis: A journey through the secretory pathway 

      Nassif, Melissa; Matus, Soledad; Castillo, Karen; Hetz Flores, Claudio (2010)
      Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motoneuron degenerative disease characterized by the selective loss of motoneurons in the spinal ventral horn, most brainstem nuclei, and the cerebral ...
    • BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response 

      Castillo, Karen; Rojas Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamín; Nassif, Melissa; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena; Glavic Maurer, Álvaro; Hetz Flores, Claudio (2011)
      Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
    • Ca2+-dependent K+ channels from rat olfactory cilia characterized in planar lipid bilayers 

      Castillo, Karen; Bacigalupo Vicuña, Juan; Wolff Fernández, José (ELSEVIER SCIENCE BV, 2005-03-14)
      Olfactory cilia contain cyclic nucleotide-gated and Ca2+-dependent Cl- conductances that underlie excitatory chemotransduction, and a Ca2+-dependent K+ (K-Ca) conductance, apparently involved in inhibitory transduction. ...
    • Cellular & molecular Ca2+ microdomains in olfactory cilia support low signaling amplification of odor transduction 

      Castillo, Karen; Restrepo, Diego; Bacigalupo Vicuña, Juan (2010)
      Signal transduction depends critically on the spatial localization of protein constituents. A key question in odor transduction is whether chemotransduction proteins organize into discrete molecular complexes throughout ...
    • Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells 

      Muñoz, Pablo; Zavala, Gabriela; Castillo, Karen; Aguirre, Pabla; Hidalgo Tapia, María Cecilia; Núñez González, Marco (2006)
      Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production of ROS, ...
    • Hormesis: Protecting neurons against cellular stress in Parkinson disease 

      Matus, Soledad; Castillo, Karen; Hetz Flores, Claudio (Taylor and Francis Inc., 2012)
      Protein folding stress is a salient feature of the most frequent neurodegenerative diseases. Although the accumulation of abnormally folded proteins is a well-characterized event underlying the pathology, the way cells ...
    • Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis 

      Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
    • Plasma membrane Ca2+-ATPase in the cilia of olfactory receptor neurons: Possible role in Ca2+ clearance 

      Castillo, Karen; Delgado Arriagada, Ricardo; Bacigalupo Vicuña, Juan (BLACKWELL, 2007-09-03)
      Olfactory sensory neurons respond to odorants increasing Ca2+ concentrations in their chemosensory cilia. Calcium enters the cilia through cAMP-gated channels, activating Ca2+-dependent chloride or potassium channels. ...
    • Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress 

      Torres, Mauricio; Castillo, Karen; Armisen Yáñez, Ricardo; Stutzin Schottlander, Andrés; Soto, Claudio; Hetz Flores, Claudio (2010)
      Prion-related disorders (PrDs) are fatal neurodegenerative disorders characterized by progressive neuronal impairment as well as the accumulation of an abnormally folded and protease resistant form of the cellular prion ...
    • Properties of the voltage-gated proton channel gating currents 

      Carmona, Emerson M.; Baez Nieto, David; Pupo, Amaury; Castillo, Karen; Álvarez Araya, Osvaldo; Neely, Alan; Latorre, Ramón; González, Carlos (Cell Press, 2018)
    • Scaffolding proteins in highly purified rat olfactory cilia membranes 

      Saavedra, María Verónica; Smalla, Karl Heinz; Thomas, Ulrich; Sandoval, Soledad; Olavarria, Karel; Castillo, Karen; Delgado, María Graciela; Delgado, Ricardo; Gundelfinger, Eckart D.; Bacigalupo Vicuña, Juan; Wyneken, Ursula (2008)
      Odour-mediated signal transduction is a complex process that occurs in the cilia of olfactory sensory neurons. To gain insight in to the molecular organization of the odour transduction machinery, we developed a procedure ...