Browsing by Author "1a9c9e9d-b8ad-4b91-944f-1b87a0b35216"

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    • Acute pannexin 1 blockade mitigates early synaptic plasticity defects in a mouse model of Alzheimer's disease 
      Flores Muñoz, Carolina; Gómez, Bárbara; Mery, Elena; Mujica, Paula; Gajardo, Ivana; Córdova, Claudio; López Espíndola, Daniela; Durán Aniotz, Claudia; Hetz Flores, Claudio; Muñoz, Pablo; González Jamett, Arlek; Ardiles, Álvaro (Frontiers Media, 2020)
      Synaptic loss induced by soluble oligomeric forms of the amyloid beta peptide (sA beta os) is one of the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the cognitive deficits. These ...
    • GERO cohort protocol, Chile, 2017–2022: community-based cohort of functional decline in subjective cognitive ... 
      Slachevsky Chonchol, Andrea; Zitko, Pedro; Martínez Pernía, David; Forno, Gonzalo; Court, Felipe A.; Lillo, Patricia; Villagra Castro, Roque; Durán Aniotz, Claudia Andrea; Parrao, Teresa; Assar, Rodrigo; Orellana, Paulina; Toledo, Carolina; Rivera, Rodrigo; Ibáñez, Agustín; Parra, Mario A.; González Billault, Christian; Amieva, Helena; Thumala, Daniela (BMC, 2020)
      Background: With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly ...
    • Glucose Metabolism: A Sweet Relief of Alzheimer's Disease 
      Durán Aniotz, Claudia; Hetz Flores, Claudio (2016)
      Patients and individuals at risk for Alzheimer's disease show reduced glucose metabolism in the brain. A new study takes advantage of a fly model of Alzheimer's disease to demonstrate that enhancing glucose uptake in neurons ...
    • La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer 
      Rivera Krstulović, Catalina; Durán Aniotz, Claudia Andrea (Sociedad Médica de Santiago, 2020)
      The clinical features of Alzheimer's disease (AD), for example the progressive memory loss, are produced by neuronal loss and synaptic dysfunction. These events have been associated with histopathological alterations in ...