Now showing items 1-3 of 3

    • Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy 

      Troncoso, Rodrigo; Vicencio, José Miguel; Parra, Valentina; Nemchenko, Andriy; Kawashima, Yuki; Campo, Andrea del; Toro, Barbra; Battiprolu, Pavan K.; Aranguiz, Pablo; Chiong Lay, Mario; Yakar, Shoshana; Gillette, Thomas G.; Hill, Joseph A.; Abel, Evan Dale; LeRoith, Derek; Lavandero González, Sergio (European Society of Cardiology, 2012)
      Aims Insulin-like growth factor 1 (IGF-1) is known to exert cardioprotective actions. However, it remains unknown if autophagy, a major adaptive response to nutritional stress, contributes to IGF-1-mediated cardioprotec ...
    • Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes 

      Foncea Avila, Rocío; Gálvez, Anita; Pérez Montes, Viviana; Morales, María Paz; Calixto, Andrea; Meléndez Vergara, Jaime; González Jara, Fabián Rodrigo; Díaz Araya, Guillermo; Sapag Hagar, Mario; Sugden, Peter H.; LeRoith, Derek; Lavandero González, Sergio (ACADEMIC PRESS INC, 2000-07-05)
      This study aims to elucidate the signaling pathway for insulin-like growth factor-1 (IGF-1) in cultured neonatal rat cardiomyocytes and particularly the role of IGF-1 in cardiac apoptosis, IGF-1 stimulated polyphosphoinositide ...
    • Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes 

      Foncea, Rocío; Andersson, Monica; Ketterman, Albert; Blakesley, Vicky; Sapag Hagar, Mario; Sugden, Peter H.; LeRoith, Derek; Lavandero González, Sergio (1997)
      In response to insulin-like growth factor-I (IGF-I), neonatal rat cardiac myocytes exhibit a hypertrophic response. The elucidation of the IGF- I signal transduction system in these cells remains unknown. We show here that ...