Browsing by Author "201-0286939"

Now showing items 1-20 of 28

    • Altered Steroid Metabolism and Insulin Signaling in PCOS Endometria: Impact in Tissue Function 
      Oróstica Arévalo, María Lorena; Rosas Chuñil, Carlos; Plaza Parrochia, Francisca; Astorga Leiva, Isis; Gabler Neale, Fernando; García Angulo, Víctor; Romero Osses, Carmen; Vega Blanco, María Margarita (Bentham Science, 2016)
      Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine/metabolic disorder characterized by hyperandrogenemia and in most cases, by hyper-insulinemia in addition to obesity. Besides ovarian dysfunction, ...
    • Augmented cell survival in eutopic endometrium from women with endometriosis: Expression of c-myc, TGF-beta1 ... 
      Johnson, M. Cecilia; Torres, Marisa; Alves, Alessandra; Bacallao, Ketty; Fuentes, Ariel; Vega Blanco, María Margarita; Boric Scarpa, María Angélica (2005)
      Background: Endometriosis is a common gynaecological disorder characterized by the presence of endometrial tissue outside of the uterus. The fragments in normal menstruation are composed of necrotic and living cells, which ...
    • Effect of estradiol on the expression of angiogenic factors in epithelial ovarian cancer 
      Valladares, Macarena; Plaza Parrochia, Francisca; Lepez, Macarena; López Ponce, Daniela; Gabler Neale, Fernando; Gayan, Patricio; Selman, Alberto; Vega Blanco, María Margarita; Romero Osses, Carmen (Francisco Hernández, Editor, 2017)
      Introduction: Ovarian cancer presents a high angiogenesis (formation of new blood vessels) regulated by pro-angiogenic factors, mainly vascular endothelial growth factor (VEGF) and nerve growth factor (NGF). An association ...
    • Endometrium and steroids, a pathologic overview 
      Plaza Parrochia, Francisca; Romero Osses, Carmen; Valladares Boasi, Luis; Vega Blanco, María Margarita (Elsevier, 2017)
      Normal endometrial function requires of cell proliferation and differentiation; therefore, disturbances in these processes could lead to pathological entities such as hyperplasia and endometrial adenocarcinoma, where cell ...
    • Hyperandrogenism Decreases GRP78 Protein Level and Glucose Uptake in Human Endometrial Stromal Cells 
      Rosas Chuñil, Carlos; Oróstica Arévalo, María Lorena; Poblete, Cristian; Carvajal Gavilán, Rodrigo; Gabler Neale, Fernando; Romero Osses, Carmen; Lavandero González, Sergio; Vega Blanco, María Margarita (SAGE, 2016)
      Background: Women with polycystic ovary syndrome (PCOS) exhibit a low fertility by chronic hyperandrogenemia. Different evidence have shown that androgens could regulate the endoplasmic reticulum (ER) homeostasis and glucose ...
    • In vitro net progesterone production by human corpora lutea: Effects of human chorionic gonadotropin, ... 
      Vega Blanco, María Margarita; Devoto, Luigi; Navarro, Veronica; Castro, Olga; Kohen Skop, Paulina (1987)
      Slices of human corpora lutea (CL) obtained at varying stages of the luteal phase from 21 women were used to study the effect of hCG on progesterone (P4) production. Slices obtained from mid- and late CL incubated with 10 ...
    • Luteal leukocytes are modulators of the steroidogenic process of human mid-luteal cells 
      Castro, Andrea; Castro, Olga; Troncoso, José Luis; Kohen Skop, Paulina; Simon, Carlos; Vega Blanco, María Margarita; Devoto, Luigi (Oxford University Press, 1998)
      Flow cytometry analysis of luteal cells revealed that an important proportion of these cells are leukocytes. The percentage of leukocytes was higher in the early (42 ± 4) and late (35 ± 3) luteal phases than in the mid-luteal ...
    • Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature 
      Croxatto, Horacio B.; Devoto, Luigi; Durand, Marta; Ezcurra, Enrique; Larrea, Fernando; Nagle, Carlos; Ortiz, María Elena; Vantman, David; Vega Blanco, María Margarita; Von Hertzen, Helena (Elsevier, 2001)
    • Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ... 
      Garrido, Maritza P.; Vera, Carolina; Vega Blanco, María Margarita; Quest, Andrew F. G.; Romero Osses, Carmen (SAGE Publications Inc., 2018)
      © The Author(s), 2018. Background: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it ...
    • Metformin prevents NGF-dependent proliferative and pro-angiogenic effects in epithelial ovarian cancer and ... 
      Garrido Palma, Maritza; Vega Blanco, María Margarita; Quest, Andrew F. G.; Romero Osses, Carmen (Spandidos Publications Ltd., 2017)
    • Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells 
      Garrido Palma, Maritza; Salvatierra, Renato; Valenzuela Valderrama, Manuel; Vallejos, Christopher; Bruneau, Nicole; Hernández, Andrea; Vega Blanco, María Margarita; Selman Abuchaibe, Alberto; Geoffery Quest, Andrew; Romero Osses, Carmen (MDPI, 2020)
      Epithelial ovarian cancer (EOC) is a lethal gynaecological neoplasm characterized by rapid growth and angiogenesis. Nerve growth factor (NGF) and its high affinity receptor tropomyosin receptor kinase A (TRKA) contribute ...
    • Molecular mechanisms of androstenediol in the regulation of the proliferative process of human endometrial cells 
      Plaza Parrochia, Francisca; Oróstica Arévalo, María Lorena; García, Paula; Vera, Carolina; Romero Osses, Carmen; Valladares Boasi, Luis; Vega Blanco, María Margarita (SAGE Publications Inc, 2017)
      Proliferation in endometria of women with polycystic ovarian syndrome (PCOS) is increased, similar to the biosynthesis of androstenediol (estrogenic metabolite). As previously shown, in human endometrial cells, androstenediol ...
    • Presence of angiotensin II and expression of angiotensin II type-2 receptor in human fallopian tube 
      Johnson, M. Cecilia; Castro, Andrea; Troncoso, José Luis; Vantman, David; Devoto, Luigi; Vega Blanco, María Margarita (1998)
      Objective: To determine the presence of angiotensin II and angiotensin II type-2 receptor subtype messenger RNA (mRNA) in human fallopian tube. Design: Frozen fallopian tubes were used for all studies. Setting: Procedures ...
    • Pro-inflammatory markers negatively regulate IRS1 in endometrial cells and endometrium from women with ... 
      Oróstica Arévalo, María Lorena; Poblete Rivas, Cristian; Romero Osses, Carmen; Vega Blanco, María Margarita (Springer, 2020)
      A pro-inflammatory environment is characteristic of obesity and polycystic ovary syndrome (PCOS). This environment through cytokines secretion negatively affects insulin action. Endometria from women with both conditions ...
    • Progesterone synthesis by human luteal cells: Modulation by estradiol 
      Vega Blanco, María Margarita; Devoto, Luigi; Castro, Olga; Kohen Skop, Paulina (1994)
      To assess the role of estradiol (E2) upon progesterone (P4) synthesis, a well defined human midluteal cell system was used. A dose-dependent inhibition of P4 synthesis with and without hCG was induced by E2. In addition, ...
    • Progesterone synthesis by human luteal cells: Modulation by estradiol 
      Vega Blanco, María Margarita; Devoto, Luigi; Castro, Olga; Kohen Skop, Paulina (1994)
      To assess the role of estradiol (E2) upon progesterone (P4) synthesis, a well defined human midluteal cell system was used. A dose-dependent inhibition of P4 synthesis with and without hCG was induced by E2. In addition, ...
    • Proinflammatory environment and role of TNF-α in endometrial function of obese women having polycystic ... 
      Oróstica Arévalo, María Lorena; Astorga Leiva, Isis; Plaza Parrochia, Francisca; Vera Castillo, Carolina; García Angulo, Víctor; Carvajal Gavilán, Rodrigo; Gabler Neale, Fernando; Romero Osses, Carmen; Vega Blanco, María Margarita (Springer Nature, 2016)
      BACKGROUND/OBJECTIVES: A high percentage of women having polycystic ovarian syndrome (PCOS) exhibit hyperinsulinemia and obesity. Transforming necrosis factor-alpha (TNF-alpha) is an adipokine that increases in obesity and ...
    • Regulation of human luteal steroidogenesis in vitro by nitric oxide 
      Vega Blanco, María Margarita; Johnson, M. Cecilia; Díaz, Hugo A.; Urrutia, Luis R.; Troncoso, José L.; Devoto, Luigi (1998)
      To evaluate the effect of nitric oxide (NO·) in human corpus luteum (CL) function, we investigated the expression and the presence of NO· synthase (NOS) in the human CL and the action of NO· on the in vitro luteal ...
    • Role of dihydrotestosterone (DHT) on TGF-β1 signaling pathway in epithelial ovarian cancer cells 
      Kohan Ivani, Karla; Gabler Neale, Fernando; Selman,; Vega Blanco, María Margarita; Romero Osses, Carmen (Springer Verlag, 2016)
      © 2015, The Author(s).Purpose: One of the hypotheses regarding the genesis of epithelial ovarian cancer involves the action of androgens on the proliferation of epithelial ovarian cells, as well as inclusion cysts. The ...
    • Role of glucose-1-phosphate and glucose-6-phosphate in glycogen synthesis by pigeon liver homogenate 
      Figueroa, Enrique; Peirano, Iris; Vega Blanco, María Margarita; Vega, Patricio (1976)
      1. 1. Glucose-1-C14, G-6-P-1-C14 and G-1-P-l-C14 have been incubated with a pigeon liver homogenate. Incorporation of C14 into glycogen and CO2 were measured. 2. 2. The relative incorporation of C14 from G-6-P-1-C14 and ...