Browsing by Author "201-0432794"
Now showing items 1-19 of 19
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(Spandidos Publ. Ltd., 2016)The Tax protein of human T cell leukemia virus type 1 plays a major role in the pathogenesis of adult T cell leukemia (ATL), an aggressive neoplasia of CD4(+) T cells. In the present study, we investigated whether the ...
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(ELSEVIER SCI IRELAND, 1998-07-03)The electron-donating ability of gallates, which are food and pharmaceutical antioxidants, is quantitatively assessed on the basis of their electrochemical characteristics. Gallic acid and the propyl, i-propyl, butyl, ...
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(Spandidos Publ, 2014)Early growth response-1 (Egr-1) and the non-receptor protein tyrosine kinase (c-Abl) are 2 response genes that can act as regulators of cell growth and apoptosis in response to stress. Both Egr-1 and c-Abl regulate cell ...
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(Elsevier, 2017)We previously demonstrated that alkyl gallates coupled to triphenylphosphine have a selective and efficient antiproliferative effect by inducing mitochondria] uncoupling in vitro due to the increased mitochondrial trans ...
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(2016)Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium ...
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(2016)Background: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T. ...
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(Universidad de Chile, 2012)Los cambios en la síntesis de ATP mitocondrial pueden afectar el desempeño de células tumorales, debido a que el primer paso de la glicólisis es dependiente del ATP mitocondrial que proviene de la fosforilación oxidativa. ...
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(NATURAL PRODUCTS INC, 2008)A set of structurally related compounds incorporating a chromone moiety as an essential component of their structures were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant TA3-MTX-R. A ...
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(Universidad de Chile, 2015)Estudios previos han demostrado que derivados del ácido gálico unidos a trifenilfosfonio mediante una cadena alifática de diez carbonos son efectivos agentes citotóxicos, desacoplando la cadena transportadora de electrones ...
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(Universidad de Chile, 2011)En estudios anteriores se ha observado que algunas hidroquinonas, que poseen un núcleo naftaleno con la característica de tener el grupo hidroxilo conjugado con un sustituyente carbonilo, presentan actividad antitumoral. ...
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(Universidad de Chile, 2012)Se sintetizaron sales de fosfonio derivadas del ácido gálico con potencial actividad biológica, por medio de dos estrategias sintéticas. La primera ruta está compuesta de 3 pasos, donde la esterificación se realizó a través ...
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(2011)Previous studies suggest that the effects of Egr-1 on tumorigenesis are critically dependent on the levels of Egr-1 and the cellular context. For this reason, we examined the effects of blocking the Egr-1 activity by a ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 1994-11-16)The effects of nordihydroguaiaretic acid (NDGA), best known as an inhibitor of lipoxygenase activities, on the culture growth, oxygen consumption, ATP level, viability, and redox state of some electron carriers of intact ...
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(Universidad de Chile, 2012-12)Se ha descrito que los ésteres derivados del ácido gálico poseen efecto citotóxico sobre las células tumorales. En este trabajo se analizaron los mecanismos de muerte celular, inducidos por los compuestos catiónicos ...
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(Elsevier, 2020)Introduction: Colorectal cancer (CRC) is a critical health issue worldwide. The high rate of liver and lung metastasis associated with CRC creates a significant barrier to effective and efficient therapy. Tumour cells, ...
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(Elsevier, 2013)Tumor cells present a known metabolic reprogramming, which makes them more susceptible for a selective cellular death by modifying its mitochondrial bioenergetics. Anticancer action of the antioxidant 9,10- dihydroxy-4 ...
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(Elsevier, 2014)Polyphenols, ubiquitously present in fruits and vegetables, have been traditionally viewed as antioxidant molecules. Such contention emerged, mainly from their well established in vitro ability to scavenge free radicals ...
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(Academic Press Elsevier Science, 2016)Mitochondria participate in several distinctiveness of cancer cell, being a promising target for the design of anti-cancer compounds. Previously, we described that ortho-carbonyl hydroquinone scaffold 14 inhibits the complex ...
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(Elsevier, 2017)Hemocyanins have highly conserved copper-containing active sites that bind oxygen. However, structural differences among the hemocyanins of various mollusks may affect their physicochemical properties. Here, we studied ...
