Browsing by Author "201-0553135"
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Asociación de mayores niveles de RANKL y linfocitos T CD4+ en periodontitis
Vernal Astudillo, Rolando; Chaparro, Alejandra; Dutzan Muñoz, Nicolás; Chandía Espinosa, Sabrita; Puente Piccardo, Javier; Silva, Augusto; Gamonal Aravena, Jorge Antonio (Escuela de Odontología. Facultad de Salud. Universidad del Valle, 2004)Propósito: La periodontitis es una enfermedad infecciosa que involucra una sobre-respuesta inmune del hospedero y se caracteriza por la destrucción de los tejidos de soporte del diente.Durante su desarrollo se establece ... -
Caracterización de aislados clínicos de Porphyromonas gingivalis y su efecto en la viabilidad de células epiteliales gingivales
Bugueño Valdebenito, Isaac Maximiliano (Universidad de Chile, 2014)La periodontitis es una enfermedad infecciosa multifactorial, caracterizada por una respuesta inflamatoria exacerbada que produce la destrucción de las estructuras que dan soporte al diente, incluyendo la encía, el ... -
Changes in lipopolysaccharide profile of Porphyromonas gingivalis clinical isolates correlate with changes in colony morphology and polymyxin B resistance
Díaz, Leonor; Hoare, Anilei; Soto, Cristopher; Bugueño, Isaac; Silva Steffens, Nora; Dutzan Muñoz, Nicolás; Venegas, Darna; Salinas, Daniela; Pérez Donoso, José; Gamonal Aravena, Jorge Antonio; Bravo Rodríguez, Denisse (Elsevier, 2015)Virulence factors on the surface of Porphyromonas gingivalis constitute the first line of interaction with host cells and contribute to immune modulation and periodontitis progression. In order to characterize surface ... -
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells
Silva Steffens, Nora; Dutzan Muñoz, Nicolás; Hernández Ríos, Emma; Dezerega Piwonka, Andrea; Rivera Escobar, Oriana; Aguillón Gutiérrez, Juan Carlos; Aravena, Octavio; Lastres, Pedro; Pozo, Patricia; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio (Blackwell, 2008)Background and aims: Periodontitis is an infection with an episodic nature of tissue support destruction. The aim of this work was to determine the levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal ... -
Chemokine Monocyte Chemoattractant Protein-3 in Progressive Periodontal Lesions in Patients With Chronic Periodontitis
Dezerega Piwonka, Andrea; Pozo, Patricia; Hernández Ríos, Emma; Oyarzún Droguett, Alejandro; Rivera Escobar, Oriana; Dutzan Muñoz, Nicolás; Gutiérrez Fernández, Ana; Overall, Christopher M.; Garrido, Mauricio; Alcota Rojas, Marcela; Ortiz, Emilio; Gamonal Aravena, Jorge Antonio (American Academy of Periodontology, 2010-02)Background: Chemokines are central in the activation and direction of leukocyte subsets to target tissues. However, the monocyte chemoattractant protein-3 (MCP-3) has not been associated with chronic periodontitis. Chronic ... -
Cuantificación de células infiltrantes CD4+, CD8+ y CD19+ en el tejido gingival de individuos con periodontitis crónica
Cisterna Vergara, Carlos Patricio (Universidad de Chile, 2007)La periodontitis es una enfermedad inflamatoria del tejido periodontal, iniciada por el biofilm subgingival, que genera la destrucción progresiva de las estructuras de inserción dentaria. La naturaleza de la respuesta ... -
Establishment and Stability of the Murine Oral Microbiome
Abusleme Ramos, Loreto Andrea; O'Gorman, H.; Dutzan Muñoz, Nicolás; Greenwell-Wild, T.; Moutsopoulos, N. M. (SAGE, 2020)Commensal microbiomes exert critical functions at barrier sites. In particular, establishment of the commensal microbiome after birth dictates immune functionality and tissue homeostasis at mucosal surfaces. To investigate ... -
Expresión de metaloproteinasa de matriz ectracelular-13 (MMP-13) en dientes con periodontitis apical asintomática
González de la Fuente, Paulina Andrea (Universidad de Chile, 2010)Introducción La periodontitis apical asintomática (PAa) es una respuesta inmunoinflamatoria local a la invasión microbiana de la pulpa, que resulta en la destrucción de los tejidos periapicales. La metaloproteinasa de ... -
Expresión de metaloproteinasas de matriz extracelular (MMPs) -2, -13 y -14 en dientes con periodontitis apical crónica y tejido periapical sano
Mundi Burgos, Verónica Andrea (Universidad de Chile, 2009)Introducción La periodontitis apical crónica (PAC) es una patología inmunoinflamatoria caracterizada por destrucción ósea asociada a inflamación crónica y expresión de mediadores moleculares, dentro de los cuales ... -
High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4+ T lymphocytes
Vernal Astudillo, Rolando; Dutzan Muñoz, Nicolás; Hernández Ríos, Emma; Chandía Espinosa, Sabrita; Puente Piccardo, Javier; León Berríos, Rubén; García, Leyre; Valle, Ignacio del; Silva, Augusto; Gamonal Aravena, Jorge Antonio (American Academy of Periodontology, 2006-10)Background: Chronic periodontitis is an infectious disease characterized by alveolar bone destruction and teeth loss. Receptor activator of nuclear factor-kappa B ligand (RANKL) is an osteoclastogenic cytokine, a central ... -
Host response mechanisms in periodontal diseases
Silva, Nora; Abusleme Ramos, Loreto Andrea; Bravo, Denisse; Dutzan Muñoz, Nicolás; García Sesnich, Jocelyn; Vernal Astudillo, Rolando; Hernández, Marcela; Gamonal Aravena, Jorge Antonio (Univ Sao Paulo Fac Odontologia Bauru, 2015)Periodontal diseases usually refer to common inflammatory disorders known as gingivitis and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm, including Porphyromonas gingivalis, ... -
Host-pathogen interactions in progressive chronic periodontitis
Hernández Ríos, Emma; Dutzan Muñoz, Nicolás; García Sesnich, Jocelyn; Abusleme Ramos, Loreto Andrea; Dezerega Piwonka, Andrea; Silva Steffens, Nora; González Bergas, Fermín; Vernal Astudillo, Rolando; Sorsa, T.; Gamonal Aravena, Jorge Antonio (Sage, 2011-10)Periodontitis is an infection characterized by the occurrence of supporting tissue destruction with an episodic nature. Disease progression is often determined by the loss of attachment level or alveolar bone, and sequential ... -
Incremento en los niveles de interleuquina-21 y su papel en la patogenia de los granulomas periapicales :|bFinanciado por: FONDECYT: 1090461, FONDECYT 1090046
Navarrete Tricallotis, Mónica Oriana (Universidad de Chile, 2010)Objetivo: Los granulomas periapicales (GPs) son lesiones de naturaleza infecciosa de origen pulpar caracterizados por la destrucción de los tejidos perirradiculares, en particular del hueso alveolar periapical. El fenotipo ... -
Interferon-g, Interleukins-6 and -4, and Factor XIII-A as Indirect Markers of the Classical and Alternative Macrophage Activation Pathways in Chronic Periodontitis
Navarrete, Mariely; García, Jocelyn; Dutzan Muñoz, Nicolás; Henríquez, Leslie; Puente Piccardo, Javier; Carvajal, Paola; Hernández Ríos, Marcela; Gamonal Aravena, Jorge Antonio (Elsevier, 2014)Background: Macrophages account for 5% to 30% of the inflammatory infiltrate in periodontitis and are activated by the classic and alternative pathways. These pathways are identified by indirect markers, among which ... -
Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients
Dutzan Muñoz, Nicolás; Vernal Astudillo, Rolando; Vaque, Jose; García Sesnich, Jocelyn; Hernandez, Marcela; Abusleme, Loreto; Dezerega, Andrea; Gutkind, J.; Gamonal Aravena, Jorge Antonio (2012)Background: Interleukin-21 (IL-21) controls the differentiation of T-helper Th17 cells and induces the production of IL-17 in this T-cell subtype. The aim of this study is to determine the relative expression of IL-21 ... -
Levels of Interferon-Gamma and Transcription Factor T-Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis
Dutzan Muñoz, Nicolás; Vernal Astudillo, Rolando; Hernández Ríos, Emma; Dezerega Piwonka, Andrea; Rivera Escobar, Oriana; Silva Steffens, Nora; Aguillón Gutiérrez, Juan Carlos; Puente Piccardo, Javier; Pozo, Patricia; Gamonal Aravena, Jorge Antonio (2009-02)Background: Periodontitis is an infection with an episodic pattern of tissue-support destruction. During the generation of a primary CD4+ T helper 1 (Th1) response, interferon-gamma (IFN-g) acts as a positive regulator ... -
Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis
Vernal Astudillo, Rolando; Dutzan Muñoz, Nicolás; Chaparro, Alejandra; Puente Piccardo, Javier; Valenzuela, María Antonieta; Gamonal Aravena, Jorge Antonio (BLACKWELL MUNKSGAARD, 2005-04)Background and Aims: Interleukin-17 (IL-17) is a T-cell-derived cytokine that may play an important role in the initiation or maintenance of the pro-inflammatory response and has recently been found to stimulate osteoclastic ... -
Levels of interleukin-21 in patients with untreated chronic periodontitis
Dutzan Muñoz, Nicolás; Rivas, Catalina; García Sesnich, Jocelyn; Henríquez, Leslie; Rivera Escobar, Oriana; Dezerega Piwonka, Andrea; Hernández Ríos, Emma; Silva Steffens, Nora; Aguillón Gutiérrez, Juan Carlos; Puente Piccardo, Javier; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio (American Academy of Periodontology, 2011-10)BACKGROUND: A growing body of evidence suggested that interleukin (IL)-21 enhances the effector phase during T-cell responses. The aim of our study is to determine the levels of IL-21 in periodontal sites from patients ... -
Localización tisular de metaloproteinasa de matriz-12 (MMP-12) en lesiones periapicales consecutivas a necrosis pulpar séptica y en tejido periodontal sano
Jerez Ríos, María Pilar (Universidad de Chile, 2012)Introducción: La Periodontitis Apical Asintomática (PAA) corresponde a una patología inflamatoria causada por microorganismos que invaden los canales radiculares del diente. Se caracteriza por la destrucción de los ... -
Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells
González Bergas, Fermín; Ortiz, Carolina; Reyes Rojas, Montserrat; Dutzan Muñoz, Nicolás; Patel, Vyomesh; Pereda, Cristián; Gleisner Muñoz, María Alejandra; López Nitsche, Mercedes; Gutkind, J. Silvio; Salazar Onfray, Flavio (John Wiley & Sons Ltd,, 2014)We have previously reported a novel method for the production of tumour-antigen-presenting cells (referred to as TAPCells) that are currently being used in cancer therapy, using an allogeneic melanomaderived cell lysate ...