Now showing items 1-13 of 13

    • Angiotensin II triggers apoptosis in cardiac fibroblast but not in myofibroblast overexpressing the type 1 receptor 

      Díaz Araya, Guillermo; Vivar Sánchez, Raúl; Soto, C.; Copaja, Miguel; Mateluna, F.; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; Thomas, W. G.; Lavandero González, Sergio (BLACKWELL PUBLISHING, 2007-07)
      Meeting Abstract
    • Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells 

      Antileo, Elmer; Garri, Carolina; Tapia, Victoria; Muñoz, Juan Pablo; Chiong Lay, Mario; Nualart, Francisco; Lavandero González, Sergio; Díaz Fernández, Juan Cristóbal; Núñez González, Marco (American Physiological Society, 2013)
      Ferritin, a food constituent of animal and vegetal origin, is a source of dietary iron. Its hollow central cavity has the capacity to store up to 4,500 atoms of iron, so its potential as an iron donor is advantageous to ...
    • Functional interaction between human papillomavirus type 16 E6 and E7 oncoproteins and cigarette smoke components in lung epithelial cells 

      Muñoz, Juan Pablo; González, Carolina; Parra, Bárbara; Corvalán, Alejandro H.; Tornesello, Maria Lina; Eizuru, Yoshito; Aguayo, Francisco (2012)
      The smoking habit is the most important, but not a sufficient cause for lung cancer development. Several studies have reported the human papillomavirus type 16 (HPV16) presence and E6 and E7 transcripts expression in lung ...
    • IGF-1: Un factor de crecimiento con acciones cardiovasculares pleiotrópicas. 

      Contreras Ferrat, Ariel Eduardo; Aránguiz Urroz, Pablo Daniel; Díaz Elizondo, Jessica; Chiong Lay, Mario; Muñoz, Juan Pablo; Parra Ortíz, María Valentina; Ibarra, Cristián; Rojas Rivera, Diego; Troncoso Cotal, Rodrigo; Eisner, Verónica; Salas, Daniela; Rodríguez Villarroel, Andrea Elizabeth; Carrasco Alarcón, Loreto del Pilar; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      El factor de crecimiento análogo a insulina tipo 1 (IGF-1) es un péptido relacionado estructural y funcionalmente con insulina que posee efectos mitogénicos y citoprotectores. Sus efectos biológicos dependen de la activación ...
    • Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress 

      Bravo Méndez, Roberto; Vicencio Bustamante, José Miguel; Parra Ortíz, María Valentina; Troncoso, Rodrigo; Muñoz, Juan Pablo; Bui, Michael; Quiroga Lagos, Clara; Rodríguez Villarroel, Andrea Elizabeth; Verdejo, Hugo E.; Ferreira Parker, Jorge; Iglewski, Miriam; Chiong Lay, Mario; Simmen, Thomas; Zorzano, Antonio; Hill, Joseph A.; Rothermel, B. A.; Szabadkai, Gyorgy; Lavandero González, Sergio (COMPANY OF BIOLOGISTS LTD., 2011-07-15)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but that beyond a certain degree of ER damage, this response triggers apoptotic pathways. The ...
    • Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress (vol 124, pg 2143, 2011) 

      Bravo Méndez, Roberto; Vicencio Bustamante, José Miguel; Parra Ortíz, María Valentina; Troncoso Cotal, Rodrigo; Muñoz, Juan Pablo; Bui, Michael; Quiroga Lagos, Clara; Rodríguez Villarroel, Andrea Elizabeth; Verdejo, Hugo; Ferreira Parker, Jorge; Iglewski, Miriam; Chiong Lay, Mario; Simmen, Thomas; Zorzano, Antonio; Hill, Joseph A.; Rothermel, B. A.; Szabadkai, G.; Lavandero González, Sergio (COMPANY OF BIOLOGISTS LTD, 2011-07-15)
    • Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide 

      Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Troncoso Cotal, Rodrigo Andrés; Toro, Barbra; Pedrozo Cibils, Zully; Díaz Elizondo, Jessica; Salas, Daniela; Parra Ortíz, María Valentina; Núñez González, Marco; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2010-02-15)
      We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
    • Merkel cell polyomavirus in non-small cell lung carcinomas from Chile 

      Gheit, Tarik; Muñoz, Juan Pablo; Levican, Jorge; González, Carolina; Ampuero Llanos, Sandra; Parra, Bárbara; Gaggero Brillouet, Aldo; Corvalán, Alejandro H.; Uribe Meneses, Manuel Ángel; Tommasino, Massimo; Aguayo, Francisco (2012)
      Lung cancer is a leading pathology strongly associated with the smoking habit. However, a viral etiology for a subset of patients developing lung cancer has been suggested. Polyomaviruses (PyVs) are small double stranded ...
    • Mitochondria, myocardial remodeling, and cardiovascular disease 

      Verdejo, Hugo E.; Del Campo, Andrea; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan Pablo; García, Lorena; Castro, Pablo F.; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core ofmost cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Ni/Ni oxides nanoparticles with potential biomedical applications obtained by displacement of a nickel-organometallic complex 

      Rodríguez Llamazares, Saddys María; Merchán, Juan; Olmedo, Ivonne; Marambio, Héctor Pablo; Muñoz, Juan Pablo; Jara, Paul; Sturm, Juan Carlos; Chornik, Boris; Peña, Octavio; Yutronic Sáez, Nicolás; Kogan Bocian, Marcelo (2008)
      A new synthesis and stabilization method was developed for paramagnetic nanoparticles composed of nickel and nickel oxides. Nickel/nickel oxides nanoparticles were synthesized by a method based on ligand displacement of ...
    • Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor 

      Sánchez Vivar, Raúl; Soto, Cristián; Copaja, Miguel; Mateluna Guajardo, María Francisca; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Letelier Vargas, Alan Gonzalo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2008-08)
      Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type I receptor (AT(1)R), and changes in its expression have been reported in ...
    • Separación de lantano (III), cerio (III), praseodimio (III) y neodimio (III) mediante extracción por solventes utilizando extractantes organofosforados 

      Muñoz Muñoz, Juan Pablo (Universidad de Chile, 2011)
      En esta Memoria de Título se estudió la extracción y separación de lantano (III), cerio (III), praseodimio (III) y neodimio (III) mediante extracción por solventes utilizando como agentes transportadores los extractantes ...
    • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling 

      Muñoz, Juan Pablo; Collao, Andrés; Chiong Lay, Mario; Maldonado Vera, Carola Patricia; Adasme, Tatiana; Carrasco Alarcón, Loreto del Pilar; Ocaranza Osses, Paula; Bravo Méndez, Roberto; González, Leticia; Díaz Araya, Guillermo; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-09)
      Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) ...