Now showing items 1-4 of 4

    • 4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo 

      Sotomayor Zárate, Ramón; Quiroz, Gabriel; Araya, Katherine A.; Abarca, Jorge; Ibáñez, María R.; Montecinos, Alejandro; Guajardo, Carlos; Núñez, Gabriel; Fierro, Angélica; Moya, Pablo R.; Iturriaga-Vásquez, Patricio; Gómez-Molina, Cristóbal; Gysling, Katia; Reyes Parada, Miguel (2012)
      4-Methylthioamphetamine (MTA) is a phenylisopropylamine derivative whose use has been associated with severe intoxications. MTA is usually regarded as a selective serotonin-releasing agent. Nevertheless, previous data have ...
    • Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats 

      Quiroz, Gabriel; Guerra-Díaz, Nicolás; Iturriaga-Vásquez, Patricio; Rivera Meza, Mario; Quintanilla González, María Elena; Sotomayor Zárate, Ramón (Elsevier, 2018-09)
      Alcohol abuse is a worldwide health problem with high economic costs to health systems. Emerging evidence suggests that modulation of brain nicotinic acetylcholine receptors (nAChRs) may be a therapeutic target for alcohol ...
    • Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core 

      Méndez-Rojas, Claudio; Quiroz, Gabriel; Faúndez, Mario; Gallardo Garrido, Carlos Andrés; Pessoa Mahana, Carlos David; Chung, Hery; Gallardo Toledo, Eduardo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Kogan Bocian, Marcelo; Zúñiga López, María C.; Iturriaga-Vásquez, Patricio; (Wiley-VCH Verlag, 2018)
      © 2018 Deutsche Pharmazeutische Gesellschaft With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated ...
    • Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT 

      Pessoa Mahana, Hernán; Silva Matus, Paul Eduardo; Pessoa Mahana, Carlos David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata Torres, Gerald; Saitz Barría, Claudio; Araya Maturana, Ramiro; Reyes Parada, Miguel (Wiley, 2017)
      A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the ...