Now showing items 1-7 of 7

    • A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia 

      Adhikari, Kaustubh; Mendoza-Revilla, Javier; Sohail, Anood; Fuentes Guajardo, Macarena; Lampert, Jodie; Chacón-Duque, Juan Camilo; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Acuña-Alonzo, Victor; Jaramillo, Claudia; Arias, William; Lozano, Rodrigo Barquera; (Nature Publishing Group, 2019)
      We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation ...
    • Adaptation to milking agropastoralism in Chilean goat herders and nutritional benefit of lactase persistence 

      Montalva, Nicolás; Adhikari, Kaustubh; Liebert, Anke; Mendoza Revilla, Javier; Flores, Sergio V.; Mace, Ruth; Swallow, Dallas M. (Wiley, 2019)
      The genetic trait of lactase persistence (LP) evolved as an adaptation to milking pastoralism in the Old World and is a well-known example of positive natural selection in humans. However, the specific mechanisms conferring ...
    • Admixture in Latin America: Geographic Structure, Phenotypic Diversity and Self-Perception of Ancestry Based on 7,342 Individuals 

      Ruiz Linares, Andrés; Adhikari, Kaustubh; Acuña Alonzo, Víctor; Quinto Sánchez, Mirsha; Jaramillo, Claudia; Arias, William; Fuentes, Macarena; Pizarro, María; Everardo, Paola; de Avila, Francisco; Gómez Valdés, Jorge; León Mimila, Paola; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Burley, Mari-Wyn; Konca, Esra; Zagonel de Oliveira, Marcelo; Veronez, Mauricio Roberto; Rubio Codina, Marta; Attanasio, Orazio; Gibbon, Sahra; Ray, Nicolás; Gallo, Carla; Poletti, Giovanni; Rosique, Javier; Schuler-Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria-Cátira; Canizales Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; Balding, David; González-José, Rolando (Public Library of Science, 2014)
      The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social ...
    • Facial Asymmetry and Genetic Ancestry in Latin American Admixed Populations 

      Quinto Sánchez, Mirsha; Adhikari, Kaustubh; Acuña Alonzo, Víctor; Cintas, Celia; Silva de Cerqueira, Caio Cesar; Ramallo, Virginia; Castillo, Lucia; Farrera, Arodi; Jaramillo, Claudia; Arias, Williams; Fuentes, Macarena; Everardo, Paola; Ávila, Francisco de; Gómez Valdés, Jorge; Hünemeier, Tabita; Gibbon, Shara; Gallo, Carla; Poletti, Giovanni; Rosique, Javier; Bortolini, María Cátira; Canizales Quinteros, Samuel; Rothhammer Engel, Francisco; Bedoya, Gabriel; Ruiz Linares, Andrés; González José, Rolando (Wuley Blackwell, 2015)
      Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants ...
    • A genome-wide association study identifies multiple loci for variation in human ear morphology 

      Adhikari, Kaustubh; Reales, Guillermo; Smith, Andrew J.P.; Konka, Esra; Palmen, Jutta; Quinto Sánchez, Mirsha; Acuña Alonzo, Víctor; Jaramillo, Claudia; Arias, William; Fuentes, Macarena; Pizarro, María; Barquera Lozano, Rodrigo; Macín Pérez, Gastón; Gómez Valdés, Jorge; Villamil Ramírez, Hugo; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio C.; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria Cátira; Canizales Quinteros, Samuel; Rothhammer Engel, Francisco; Bedoya, Gabriel; Calderón, Rosario; Rosique, Javier; Cheeseman, Michael; Bhutta, Mahmood F.; Humphries, Steve E.; González José, Rolando; Headon, Denis; Balding, David; Ruiz Linares, Andrés (Nature Publishing, 2015)
      Here we report a genome-wide association study for non-pathological pinna morphology in over 5,000 Latin Americans. We find genome-wide significant association at seven genomic regions affecting: lobe size and attachment, ...
    • Obesity, genomic ancestry, and socioeconomic variables in Latin American mestizos 

      Ruderman, Anahí; Pérez, Luis O.; Adhikari, Kaustubh; Navarro, Pablo; Ramallo, Virginia; Gallo, Carla; Poletti, Giovanni; Bedoya, Gabriel; Bortolini, Maria C.; Acuña-Alonzo, Victor; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Ruiz-Linares, Andres; González-José (Wiley-Liss Inc., 2019)
      Objectives: This article aims to assess the contribution of genomic ancestry and socioeconomic status to obesity in a sample of admixed Latin Americans. Methods: The study comprised 6776 adult volunteers from Brazil, Chile, ...
    • Variation in dental morphology and inference of continental ancestry in admixed Latin Americans 

      Delgado, Miguel; Ramírez, Luis Miguel; Adhikari, Kaustubh; Fuentes-Guajardo, Macarena; Zanolli, Clément; Gonzalez-José, Rolando; Canizales, Samuel; Bortolini, Maria Catira; Poletti, Giovanni; Gallo, Carla; Rothhammer, Francisco; Bedoya, Gabriel; Ruiz-Linares, Andres (Wiley-Liss Inc., 2019)
      © 2018 Wiley Periodicals, Inc. Objectives: To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin ...