Now showing items 1-17 of 17

    • Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension 

      Martínez Aguayo, Alejandro; Campino, Carmen; Baudrand, René; Carvajal, Cristian; Garcia, Hernán; Aglony, Marlene; Bancalari, Rodrigo; García Nannig, Lorena; Loureiro, Carolina; Vecchiola, Andrea; Tapia Castillo, Alejandra; Valdivia, Carolina; Sanhueza, Sebastián; Fuentes, Cristóbal; Lagos, Carlos F.; Solari, Sandra; Allende, Fidel; Kalergis, Alexis; Fardella, Carlos E. (Lippincott Williams & Wilkins, 2016)
      Objective: To identify novel biomarkers associated with pediatric primary hypertension. Methods: We recruited 350 participants (4-16 years). Anthropometric parameters and aldosterone, plasma renin activity, cortisol, ...
    • Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function 

      Jara, Oscar; Acuña, Rodrigo; García, Isaac E.; Maripillán, Jaime; Figueroa, Vania; Sáez, Juan C.; Araya Secchi, Raúl; Lagos, Carlos F.; Pérez Acle, Tomás; Berthoud, Viviana M.; Beyer, Eric C.; Martínez, Agustín D. (2012)
      To identify motifs involved in oligomerization of the gap junction protein Cx26, we studied individual transmembrane (TM) domains and the full-length protein. Using the TOXCAT assay for interactions of isolated TM α-helices, ...
    • Design, synthesis, binding and docking-based 3D-QSAR studies of 2-pyridylbenzimidazoles - A new family of high affinity CB1 cannabinoid ligands 

      Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)
      A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
    • Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles-A New Family of High Affinity CB1 Cannabinoid Ligands 

      Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)
      A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
    • Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting the cannabinoid receptor type 1 

      Espinosa Bustos, Christian; Lagos, Carlos F.; Romero Parra, Javier; Zárate, Ana M.; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Iturriaga-Vásquez, Patricio; Tapia, Ricardo A.; Pessoa Mahana, Carlos David (Wiley-VCH Verlag, 2015)
      © 2015 Wiley-VCH Verlag GmbH & Co. KGaA. A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand ...
    • Dictyostelium discoideum as a surrogate host-microbe model for antivirulence screening in Pseudomonas aeruginosa PAO1 

      Bravo Toncio, Catalina; Álvarez, Javiera A.; Campos, Francisca; Ortíz Severín, Javiera; Varas, Macarena; Cabrera Paucar, Ricardo; Lagos, Carlos F.; Chávez, Francisco P. (Elsevier B.V., 2016)
      © 2016 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.The interest of the pharmaceutical industry in developing new antibiotics is decreasing, as established screening systems which identify ...
    • Dictyostelium discoideum as a surrogate host–microbe model for antivirulence screening in Pseudomonas aeruginosa PAO1 

      Bravo Toncio, Catalina; Alvárez, Javiera A.; Campos, Francisca; Ortiz Severin, Javiera; Varas, Macarena; Cabrera Paucar, Ricardo; Lagos, Carlos F.; Chávez, Francisco P. (Elsevier, 2016)
      The interest of the pharmaceutical industry in developing new antibiotics is decreasing, as established screening systems which identify compounds that kill or inhibit the growth of bacteria can no longer be used. Consequently, ...
    • The Expression of RAC1 and Mineralocorticoid Pathway- Dependent Genes are Associated With Different Responses to Salt Intake 

      Tapia Castillo, Alejandra; Carvajal, Cristian; Campino, Carmen; Hill, Caroline; Allende, Fidel; Vecchiola, Andrea; Carrasco, Carmen; Bancalari, Rodrigo; Valdivia, Carolina; Lagos, Carlos; Martínez Aguayo, Alejandro; García, Hernán; Aglony, Marlene; Baudrand, René; Kalergis, Alexis; Michea Acevedo, Luis; Riedel, Claudia; Fardella, Carlos (Oxford University Press, 2015)
      BACKGROUND Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect the expression of oxidative stress markers, such as ...
    • Identification of novel 11b-HSD1 inhibitors by combined ligand- and structure-based virtual screening 

      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristóbal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia Castillo, Alejandra; Baudrand, René; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A.; Fardella, Carlos E. (Elsevier, 2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11b-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening 

      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristobal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia-Castillo, Alejandra; Baudrand, Rene; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A.; F (2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11β-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione 

      Lagos, Carlos F.; Araya Secchi, Raúl; Thomas, Pablo; Pérez-Acle, Tomás; Tapia, Ricardo A.; Salas, Cristian O. (2012)
      Trypanosoma cruzi glutamate cysteine ligase (TcGCL) is considered a potential drug target to develop novel antichagasic drugs. We have used a variety of computational methods to investigate the interactions between TcGCL ...
    • Novel splice-affecting variants in CYP27A1 gene in two Chilean patients with Cerebrotendinous Xanthomatosis 

      Smalley, Susan; Preiss, Yudith; Suazo Sanhueza, José Lorenzo; Vega, Javier; Angellotti, Isidora; Lagos, Carlos; Rivera, Enzo; Kleinsteuber, Karin; Campion, Javier; Martínez, J. Alfredo; Maiz, Alberto; Santos, José Luis (Sociedade Brasileira de Genética, 2015)
      Cerebrotendinous Xanthomatosis (CTX), a rare lipid storage disorder, is caused by recessive loss-of-function mutations of the 27-sterol hydroxylase (CYP27A1), producing an alteration of the synthesis of bile acids, with ...
    • On biophysical properties and sensitivity to gap junction blockers of connexin 39 hemichannels expressed in hela cells 

      Vargas, Anibal A.; Cisterna, Bruno A.; Saavedra-Leiva, Fujiko; Urrutia, Carolina; Cea, Luis A.; Vielma, Alex H.; Gutiérrez Maldonado, Sebastián; Martin, Alberto J.M.; Pareja-Barrueto, Claudia; Escalona, Yerko; Schmachtenberg, Oliver; Lagos, Carlos F.; Pérez-Acle, Tomás (Frontiers Research Foundation, 2017)
      © 2017 Vargas, Cisterna, Saavedra-Leiva, Urrutia, Cea, Vielma, Gutierrez-Maldonado, Martin, Pareja-Barrueto, Escalona, Schmachtenberg, Lagos, Perez-Acle and Sáez. Although connexins (Cxs) are broadly expressed by cells of ...
    • Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a chilean pediatric population 

      Tapia Castillo, Alejandra; Carvajal, Cristian A.; Campino, Carmen; Vecchiola, Andrea; Allende, Fidel; Solari, Sandra; García Nannig, Lorena; Lavandero González, Sergio; Valdivia, Carolina; Fuentes, Cristobal; Lagos, Carlos F.; Martínez Aguayo, Alejandro; Baudrand, René; Aglony, Marlene; García, Hernán; Fardella, Carlos E. (Oxford University Press, 2014)
      The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) ...
    • Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system 

      Ocaranza, María Paz; Michea Acevedo, Luis; Chiong Lay, Mario; Lagos, Carlos F.; Lavandero González, Sergio; Jalil Milad, Jorge (Portland Press Ltd, 2014)
      Chronic RAS (renin-angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic and atherogenic effects ...
    • Sodium intake is associated with endothelial damage biomarkers and metabolic dysregulation 

      Campino, Carmen; Baudrand, Rene; Valdivia, Carolina A.; Carvajal, Cristian; Vecchiola, Andrea; Tapia Castillo, Alejandra; Martínez Aguayo, Alejandro; Garcia, Hernán; García Nannig, Lorena; Allende, Fidel; Solari, Sandra; Fuentes, Cristóbal A.; Lagos, Carlos F.; Rojas, Maria (Oxford University Press, 2018)
      © American Journal of Hypertension, Ltd 2018. All rights reserved. For Permissions, please email: journals.permissions@oup.com. BACKGROUND Mounting evidence has associated high sodium (HS) intake with hypertension, ...
    • The expression of RAC1 and mineralocorticoid pathway-dependent genes are associated with different responses to salt intake 

      Tapia Castillo, Alejandra; Carvajal, Cristian A.; Campino, Carmen; Hill, Caroline; Allende, Fidel; Vecchiola, Andrea; Carrasco, Carmen; Bancalari, Rodrigo; Valdivia, Carolina; Lagos, Carlos; Martínez Aguayo, Alejandro; Garcia, Hernan; Aglony, Marlene; Baudrand, Rene F (Oxford University Press, 2015)
      © American Journal of Hypertension, Ltd 2014. All rights reserved.Background Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect ...