Now showing items 1-7 of 7

    • CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells 

      Silva-Pavez, Eduardo; Villar, Paulina; Trigo, César; Caamaño, Esteban; Niechi, Ignacio; Pérez, Pablo; Muñoz, Juan P.; Aguayo, Francisco; Burzio, Verónica A.; Varas Godoy, Manuel; Castro, Ariel F.; Colombo, María I.; Tapia, Julio C. (Nature Publishing Group, 2019)
      Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a ...
    • DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress 

      Fuentes-Villalobos, Francisco; Farkas, Carlos; Riquelme-Barrios, Sebastián; Armijo, Marisol E.; Soto-Rifo, Ricardo; Pincheira, Roxana; Castro, Ariel F. (Elsevier B.V., 2019)
      Variation in Disrupted-in-Schizophrenia 1 (DISC1) increases the risk for neurodegenerative diseases, schizophrenia, and other mental disorders. However, the functions of DISC1 associated with the development of these ...
    • Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival 

      Campos, Tania; Ziehe, Javiera; Fuentes Villalobos, Francisco; Riquelme, Orlando; Peña, Daniela; Troncoso Cotal, Rodrigo; Lavandero González, Sergio; Morín, Violeta; Pincheira, Roxana; Castro, Ariel F. (Elsevier, 2016)
      Tuberous sclerosis complex (TSC) disease results from inactivation of the TSC1 or TSC2 gene, and is characterized by benign tumors in several organs. Because TSC tumorigenesis correlates with hyperactivation of mTORC1, ...
    • Rheb Promotes Cancer Cell Survival Through p27Kip1-Dependent Activation of Autophagy 

      Campos, Tania; Ziehe, Javiera; Palma, Mario; Escobar, David; Tapia Pineda, Julio; Pincheira, Roxana; Castro, Ariel F. (Wiley and Sons, 2016)
      We previously found that the small GTPase Rheb regulates the cell-cycle inhibitor p27KIP1 (p27) in colon cancer cells by a mTORC1-independent mechanism. However, the biological function of the Rheb/p27 axis in cancer ...
    • SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes 

      Hermosilla, Viviana; Salgado, Ginessa; Riffo, Elizabeth; Escobar, David; Hepp, Matias; Farkas, Carlos; Galindo, Mario; Morín, Violeta; García-Robles, María; Castro, Ariel; Pincheira, Roxana (Wiley, 2018-06)
      SALL2 is a poorly characterized transcription factor that belongs to the Spalt-like family involved in development. Mutations on SALL2 have been associated with ocular coloboma and cancer. In cancers, SALL2 is deregulated ...
    • Sall2 transcription factor: a novel regulator of G1-S cyclins 

      Hermosilla, Viviana E.; Escobar, David E.; Hepp, Matias I.; Riffo, Elizabeth N.; Salgado, Ginessa; Morin, Violeta; Galindo, Mario A.; Castro, Ariel F.; Pincheira, Roxana (Amer Assoc. Cancer Research, 2018-05)
    • β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation 

      Pinto, Cristina; Medinas, Danilo B.; Fuentes Villalobos, Francisco; Maripillán, Jaime; Castro, Ariel F.; Martínez, Agustín D.; Osses, Nelson; Hetz Flores, Claudio; Henríquez, Juan P. (Academic Press Inc., 2019)
      Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The ...