Browsing by Author "42e839f3-3c91-4f0b-addf-f47c3515a2d2"

Now showing items 1-5 of 5

    • Chloroacil Hydroquinone Modulates Platelet Activity by Inhibition of Platelet-mitochondrial Bioenergetics 
      Fuentes, Eduardo; Araya Maturana, Ramiro; Méndez, Diego; Urra Faúndez, Félix; Mansilla, Santiago; Trostchansky, Andrés (Elsevier, 2020)
    • Complex mitochondrial dysfunction induced by TPP+-gentisic acid and mitochondrial translation inhibition ... 
      Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Peredo Silva, Liliana; Guzmán Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro Castillo, Vicente; Catalán Díaz, Mabel; Kemmerling Weis, Ulrike; Urra Faúndez, Félix; Ferreira, Jorge (MDPI, 2020)
      The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, ...
    • Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of ... 
      Urra Faúndez, Félix; Córdova Delgado, Miguel; Lapier, Michel; Orellana Manzano, Andrea; Acevedo Arévalo, Luis; Pessoa Mahana, Hernán; González Vivanco, Jaime; Martínez Cifuentes, Maximiliano; Ramírez Rodríguez, Oney; Millas Vargas, Juan; Weiss López, Boris; Pavani, Mario; Ferreira Parker, Jorge; Araya Maturana, Ramiro (Academic Press Elsevier Science, 2016)
      Mitochondria participate in several distinctiveness of cancer cell, being a promising target for the design of anti-cancer compounds. Previously, we described that ortho-carbonyl hydroquinone scaffold 14 inhibits the complex ...
    • Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation ... 
      Méndez, Diego; Urra Faúndez, Félix; Millas Vargas, Juan Pablo; Alarcón, Marcelo; Rodríguez Lavado, Julio; Palomo, Iván; Trostchansky, Andrés; Araya Maturana, Ramiro; Fuentes, Eduardo (Elsevier, 2020)
      Cardiovascular diseases are the leading cause of death in the world. Platelets have a major role in cardiovascular events as they bind to the damaged endothelium activating and forming thrombi. Although some hydroquinone ...
    • The Parotoid Gland Secretion from Peruvian Toad Rhinella horribilis (Wiegmann, 1833): Chemical Composition ... 
      Schmeda Hirschmann, Guillermo; Andrade, Jean Paulo de; Soto Vásquez, Marilu Roxana; Alvarado García, Paul Alan Arkin; Palominos, Charlotte; Fuentes Retamal, Sebastián; Mellado, Mathias; Correa, Pablo; Urra Faúndez, Félix (MDPI, 2020)
      Since Rhinella sp. toads produce bioactive substances, some species have been used in traditional medicine and magical practices by ancient cultures in Peru. During several decades, the Rhinella horribilis toad was confused ...