Browsing by Author "43e0551d-86eb-424f-849b-a56ca4fb858d"
Now showing items 1-7 of 7
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Díaz Urrutia, Christian; Olea Azar, Claudio; Zapata, Gerald A.; Lapier, Michel; Mura Mardones, Francisco; Aguilera Venegas, Benjamín; Arán, Vicente J.; López Muñoz, Rodrigo; Maya Arango, Juan (2012)A series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic ...
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Aguilera Venegas, Benjamín; Olea Azar, Claudio; Arán, Vicente J.; Maya Arango, Juan; Kemmerling Weis, Ulrike; Speisky Cosoy, Hernán; Mendizábal Emaldía, Fernando (2012)A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
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Aravena, María C.; Figueroa, Roberto; Olea Azar, Claudio; Arán, Vicente J. (2010)Cyclic Voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process ...
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Boiani, Lucia; Gerpe, Alejandra; Arán, Vicente; Torres de Ortiz, Susana; Serna, Elva; Vera de Bilbao, Ninfa; Sanabria, Luis; Yaluff, Gloria; Nakayama, Héctor; Rojas de Arias, Antonieta; Maya Arango, Juan; Morello, J.; Cerecetto, Hugo; González, Mercedes (2009)Previously, we have identified a series of 5-nitroindazoles with good antiprotozoal activities, against Trypanosoma cruzi epimastigotes and Trichomonas vaginalis. Most of them have shown very low unspecific toxicity on ...
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Pérez Cruz, Fernanda; Jullian Matthaei, Carolina; Rodríguez Borges, Jorge; Arán, Vicente; Olea Azar, Claudio (2009)Four different 5-nitroindazole derivatives (1-4) and its inclusion with Heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DM beta CD) were investigated. The stoichiometric ratios and stability constants describing the extent ...
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Rodríguez, Jorge; Gerpe, Alejandra; Aguirre, Gabriela; Kemmerling Weis, Ulrike; Piro, Oscar; Arán, Vicente; Maya Arango, Juan; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo (2009)New indazole derivatives have been developed to know about structural requirements for adequate anti-Trypanosoma cruzi activity. In relation to position 1 of indazole ring, we have observed that a butylaminopentyl substituent ...
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Martín-Escolano, Rubén; Aguilera-Venegas, Benjamín; Marín, Clotilde; Martín-Montes, Álvaro; Martín-Escolano, Javier; Medina-Carmona, Encarnación; Arán, Vicente J.; Sánchez-Moreno, Manuel (John Wiley and Sons Ltd, 2018)© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Chagas disease, a neglected tropical disease caused by infection with the protozoan parasite Trypanosoma cruzi, is a potentially life-threatening illness that affects 5–8 ...