Browsing by Author "48ff1f9d-19c3-4c37-b722-ae464d84bf15"
Now showing items 1-2 of 2
-
Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function Jara, Oscar; Acuña, Rodrigo; García, Isaac E.; Maripillán, Jaime; Figueroa, Vania; Sáez, Juan C.; Araya Secchi, Raúl; Lagos, Carlos F.; Pérez Acle, Tomás; Berthoud, Viviana M.; Beyer, Eric C.; Martínez, Agustín D. (2012)To identify motifs involved in oligomerization of the gap junction protein Cx26, we studied individual transmembrane (TM) domains and the full-length protein. Using the TOXCAT assay for interactions of isolated TM α-helices, ...
-
Pinto, Cristina; Medinas, Danilo B.; Fuentes Villalobos, Francisco; Maripillán, Jaime; Castro, Ariel F.; Martínez, Agustín D.; Osses, Nelson; Hetz Flores, Claudio; Henríquez, Juan P. (Academic Press Inc., 2019)Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The ...