Browsing by Author "4a3f7a5d-57b5-4a61-89c0-c0f4a2e9f980"
Now showing items 1-17 of 17
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(2002)Intracellular reactive iron is a source of free radicals and a possible cause of cell damage. In this study, we analyzed the changes in iron homeostasis generated by iron accumulation in neuroblastoma (N2A) cells and ...
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(2006)Mutations in the HFE gene result in hereditary hemochromatosis, a disorder of iron metabolism characterized by increased intestinal iron absorption. Based on the observation that ectopic expression of HFE strongly inhibits ...
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(1997)Previous studies have demonstrated that diferric transferrin and apotransferrin compete for the binding to basolateral transfertin receptors and that transferrin-mediated iron uptake by Caco-2 cells is inhibited by ...
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(Elsevier, 2017)Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are pathophysiological features in a number of neurodegenerative processes. The question arises as to whether ...
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(Elsevier B.V., 2017)© 2017 Elsevier B.V. Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are pathophysiological features in a number of neurodegenerative processes. The question arises ...
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(2007)Hepcidin (Hepc) is considered a key mediator in iron trafficking. Although the mechanism of Hepc action in macrophages is fairly well established, much less is known about its action in intestinal cells, one of the main ...
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Intestinal epithelia (Caco-2) cells acquire iron through the basolateral endocytosis of transferrin (1996)Although the absorption of iron through the intestinal epithelia is inversely related to body iron stores, the mechanisms by which the enterocytes sense body iron stores are unknown. Polarized enterocytes have transferrin ...
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(2005)Background: Iron is necessary for neuronal function but in excess generates neurodegeneration. Although most of the components of the iron homeostasis machinery have been described in neurons, little is known about the ...
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(2012)Iron is an essential element for life on earth, participating in a plethora of cellular processes where one-electron transfer reactions are required. Its essentiality, coupled to its scarcity in aqueous oxidative environments, ...
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(Harwood Academic Publishers GmbH, 2001)Intestinal epithelial cells have an active apical iron uptake system that is involved in the regulated absorption of iron. By the action of this system, intestinal cells acquire increasing amounts of iron with time. Since ...
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(2001)Calreticulin, a molecular chaperone involved in the folding of endoplasmic reticulum synthesized proteins, is also a shock protein induced by heat, food deprivation, and chemical stress. Mobilferrin, a cytosolic isoform ...
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(American Chemical Society, 2017)© 2016 American Chemical Society.Disturbed iron homeostasis, often coupled to mitochondrial dysfunction, plays an important role in the progression of common neurodegenerative diseases such as Parkinson’s disease (PD). ...
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(1996)Body Fe homeostasis is maintained through the regulation of Fe absorption by the intestinal epithelia. Working under the hypothesis that the intracellular concentration of Fe is instrumental in the control of its transepithelial ...
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(Society of Biology of Chile, 2000)Cells tightly regulate iron levels through the activity of iron regulatory proteins (IRPs) that bind to RNA motifs called iron responsive elements (IREs). When cells become iron-depleted. IRPs bind to IREs present in the ...
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(2012)Hallmarks of idiopathic and some forms of familial Parkinson's disease are mitochondrial dysfunction, iron accumulation and oxidative stress in dopaminergic neurons of the substantia nigra. There seems to be a causal link ...
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(1999)The cellular mechanism by which basolateral transferrin (Tf) produces an increase in apical-to-basolateral Fe flux in Caco-2 cells was analyzed. After a pulse of 59Fe from the apical medium, three types of basolateral 59Fe ...
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(2007)Reactive iron is an important prooxidant factor, whereas GSH is a crucial component of a long-term adaptive system that allows cells to function during extended periods of high oxidative stress. In this work, the adaptive ...
