Browsing by Author "54d484d3-12bd-42c3-b6ce-a1ea866afc9b"

Now showing items 1-13 of 13

    • cdk5 modulates β- and δ-catenin/Pin1 interactions in neuronal cells 
      Muñoz, Juan P.; Huichalaf, Claudia H.; Orellana, Daniel; Maccioni Baraona, Ricardo (2007)
      The cdk5/p35 complex has been implicated in a variety of functions related to brain development, including axonal outgrown and neuronal migration. In this study, by co-immunoprecipitation and pull-down experiments, we have ...
    • CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive ... 
      Silva-Pavez, Eduardo; Villar, Paulina; Trigo, César; Caamaño, Esteban; Niechi, Ignacio; Pérez, Pablo; Muñoz, Juan P.; Aguayo, Francisco; Burzio, Verónica A.; Varas Godoy, Manuel; Castro, Ariel F.; Colombo, María I.; Tapia, Julio C. (Nature Publishing Group, 2019)
      Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a ...
    • Curcumin rescues breast cells from epithelial‑mesenchymal transition and invasion induced by anti‑miR‑34a 
      Gallardo, Marcela; Kemmerling Weis, Ulrike; Aguayo González, Francisco; Bleak, Tammy; Muñoz, Juan P.; Calaf, Gloria (Spandidos Publications, 2020)
      Breast cancer is the most prevalent type of cancer among women worldwide and it is characterized by a high morbidity. Curcumin is a naturally occurring compound derived from the rhizome of Curcuma longa and is known to ...
    • Endocrine disruptors from the environment affecting breast cancer (Review) 
      Calaf, Gloria M.; Ponce-Cusi, Richard; Aguayo González, Francisco; Muñoz, Juan P.; Bleak, Tammy C. (Spandidos, 2020)
      Evaluation of carcinogenic substances from the environment is a challenge for scientists. Recently, a novel approach based on 10 key characteristics of human carcinogens classified by the International Agency for Research ...
    • High-Risk human papillomavirus and tobacco smoke interactions in epithelial carcinogenesis 
      Aguayo González, Francisco; Muñoz, Juan P.; Pérez Domínguez, Francisco; Carrillo Beltrán, Diego; Estibaliz Oliva, Carolina; Calaf, Gloria M.; Blanco, Rances; Núñez Acurio, Daniela (MDPI, 2020)
      Cervical, anogenital, and some head and neck cancers (HNC) are etiologically associated with high-risk human papillomavirus (HR-HPV) infection, even though additional cofactors are necessary. Epidemiological studies have ...
    • Human papillomavirus 16 E7 promotes EGFR/PI3K/AKT1/NRF2 signaling pathway contributing to PIR/NF-kappa B ... 
      Carrillo Beltrán, Diego; Muñoz, Juan P.; Guerrero Vásquez, Nahir; Blanco, Rancés; León, Oscár; de Souza Lino, Vanesca; Tapia Pineda, Julio; Maldonado Maldonado, Edio; Dubois Camacho, Karen; Hermoso Ramello, Marcela; Coravlán, Alejandro H.; Calaf, Gloria M.; Boccardo, Enrique; Aguayo González, Francisco (MDPI, 2020)
      A subset of oral carcinomas is etiologically related to high-risk human papillomavirus (HR-HPV) infection, with HPV16 being the most frequent HR-HPV type found in these carcinomas. The oncogenic role of HR-HPV is strongly ...
    • Local Control of Nuclear Calcium Signaling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal ... 
      Ibarra, Cristián; Vicencio, José M.; Estrada Hormazábal, Manuel; Lin, Yingbo; Rocco, Paola; Rebellato, Paola; Muñoz, Juan P.; García Prieto, Jaime; Quest, Andrew F. G.; Chiong Lay, Mario; Davidson, Sean M.; Bulatovic, Ivana; Grinnemo, Karl Henrik; Larsson, Olle; Szabadkai, Gyorgy; Uhlén, Per; Jaimovich Pérez, Enrique; Lavandero González, Sergio (American Heart Association, 2013)
      Rationale: The ability of a cell to independently regulate nuclear and cytosolic Ca2+ signaling is currently attributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms in the ...
    • Markers of epithelial-mesenchymal transition in an experimental breast cancer model induced by organophosphorous ... 
      Calaf, Gloria M.; Bleak, Tammy C.; Muñoz, Juan P.; Aguayo, Francisco (Spandidos, 2020)
      Breast cancer is a major health problem and accounted for 11.6% of all new cancer cases and 6.6% of all cancer deaths among women worldwide in 2018. However, its etiology has remained elusive. According to epidemiological ...
    • Merkel cell polyomavirus detected in head and neck carcinomas from Chile 
      Muñoz, Juan P.; Blanco, Rancés; Osorio, Julio C.; Estibaliz Oliva, Carolina; Díaz, María José; Carrillo Beltrán, Diego; Aguayo, Rebeca; Castillo, Andrés; Tapia Pineda, Julio C.; Calaf, Gloria M.; Gaggero Brillouet, Aldo; Aguayo González, Francisco (BMC, 2020)
      Background The role of human polyomaviruses (HPyVs) in epithelial tumors such as head and neck carcinomas (HNSCCs) including oral and oropharyngeal carcinomas has not been established. In this study, we evaluated for the ...
    • Regulation of p27 in the process of neuroblastoma N2A differentiation 
      Muñoz, Juan P.; Sánchez, Jaime R.; Maccioni Baraona, Ricardo (2003)
      Neuronal differentiation implies morphological and biochemical changes to generate a specialized neuron. N2A neuroblastoma cells can be promoted to undergo differentiation associated to neurites outgrowth, a process linked ...
    • The protein kinase cdk5: Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology 
      Maccioni Baraona, Ricardo; Otth, Carola; Concha, Ilona I.; Muñoz, Juan P. (2001)
      A set of different protein kinases have been involved in tau phosphorylations, including glycogen synthase kinase 3b (GSK3b), MARK kinase, MAP kinase, the cyclin-dependent kinase 5 (Cdk5) system and others. The latter ...
    • Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells 
      Carrillo, Diego; Muñoz, Juan P.; Huerta, Hernán; Leal, Gabriel; Corvalán, Alejandro; León Decap, Óscar; Calaf, Gloria M.; Urzúa Tobar, Ulises; Boccardo, Enrique; Tapia Pineda, Julio; Aguayo González, Francisco (Royal Soc., 2017)
      The hallmark of high-risk human papillomavirus (HR-HPV)-related carcinogenesis is E6 and E7 oncogene overexpression. The aim of this work was to characterize epithelial oral and cervical cancer cells that express HR-HPV ...
    • Viral infections in prostate carcinomas in Chilean patients Clinical oncology 
      Rodríguez, Hector; Levican, Jorge; Muñoz, Juan P.; Carrillo, Diego; Acevedo, Mónica L.; Gaggero Brillouet, Aldo; León, Oscar; Gheit, Tarik; Espinoza Navarro, Omar; Castillo, Jorge; Gallegos, Iván; Tommasino, Massimo; Aguayo, Francisco (BioMed Central Ltd., 2015)
      © 2015 Rodríguez et al.Background: A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence ...