Browsing by Author "54f2118d-25ef-4e88-b258-91038aa4c296"

Now showing items 1-5 of 5

    • Aldosterone, plasma renin activity, and aldosterone/renin ratio in a normotensive healthy pediatric population 
      Martínez Aguayo, Alejandro; Aglony, Marlene; Campino, Carmen; Garcia, Hernan; Bancalari, Rodrigo; Bolte, Lillian; Avalos, Carolina; Loureiro, Carolina; Carvajal, Cristian A.; Avila, Alejandra; Perez, Viviana; Inostroza, Andrea; Fardella, Carlos E. (2010)
      Primary aldosteronism is an important cause of secondary hypertension and is suspected in adults with an aldosterone/renin ratio ≥25. The normal aldosterone/renin ratio is unknown in children. The aim was to establish serum ...
    • Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension 
      Martínez Aguayo, Alejandro; Campino, Carmen; Baudrand, René; Carvajal, Cristian; Garcia, Hernán; Aglony, Marlene; Bancalari, Rodrigo; García Nannig, Lorena; Loureiro, Carolina; Vecchiola, Andrea; Tapia Castillo, Alejandra; Valdivia, Carolina; Sanhueza, Sebastián; Fuentes, Cristóbal; Lagos, Carlos F.; Solari, Sandra; Allende, Fidel; Kalergis, Alexis; Fardella, Carlos E. (Lippincott Williams & Wilkins, 2016)
      Objective: To identify novel biomarkers associated with pediatric primary hypertension. Methods: We recruited 350 participants (4-16 years). Anthropometric parameters and aldosterone, plasma renin activity, cortisol, ...
    • Identification of novel 11b-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristóbal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia Castillo, Alejandra; Baudrand, René; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A.; Fardella, Carlos E. (Elsevier, 2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11b-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary ... 
      Stehr, Carlos B.; Mellado, Rosemarie; Ocaranza, Maria P.; Carvajal, Cristian A.; Mosso, Lorena; Becerra, Elia; Solis, Margarita; García Nannig, Lorena; Lavandero González, Sergio; Jalil Milad, Jorge; Fardella, Carlos E. (2010)
      Background: Patients with primary aldosteronism experience greater left ventricular hypertrophy and a higher frequency of cardiovascular events than do essential hypertensive patients with comparable blood pressure levels. ...
    • Subclinical endothelial inflammation markers in a family with type i familial hyperaldosteronism caused by ... 
      Stehr, Carlos B.; Carvajal, Cristián A.; Lacourt, Patricia; Alcaíno Gálvez, Hernán Alejandro; Mellado, Rosemarle; Cattani, Andreína; Mosso, Lorena M.; Lavandero González, Sergio; Fardella, Carlos E. (2008)
      Background: Type I familial hyperaldosteronism is caused by the presence of a chimaeric gene CYP11B1/CYP11B2 which encodes an enzyme with aldosterone synthetase activity regulated by a drenocorticotrophic hormone (ACTH). ...