Browsing by Author "5730fe27-36bf-4248-bc0d-27db52542fb2"

Now showing items 1-5 of 5

    • Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ ... 
      Cárdenas, César; Lovy, Alenka; Silva Pavéz, Eduardo; Urra Faúndez, Félix; Mizzoni, Craig; Ahumada Castro, Ulises; Bustos, Galdo; Jaña, Fabián; Cruz, Pablo; Farías, Paula; Mendoza, Elizabeth; Huerta, Hernán; Murgas, Paola; Hunter, Martín; Ríos, Melany; Cerda Arancibia, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgó, Jordi; Foskett, James Kevin (AAAS. American Association for the Advancement of Science, 2020)
      Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ...
    • Endoplasmic reticulum mitochondria calcium communication and the regulation of mitochondrial metabolism in ... 
      Bustos, Galdo; Cruz, Pablo; Lovy, Alenka; Cárdenas Matus, Julio (Frontiers media SA, 2017)
      Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to ...
    • FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via ... 
      Urra, Félix A.; Hernández Muñoz, Felipe Andrés; Córdova Delgado, Miguel; Ramírez, María Paz; Peña Ahumada, Bárbara; Rios, Melany; Cruz, Pablo; Ahumada-Castro, Ulises; Bustos, Galdo; Silva-Pavez, Eduardo; Pulgar Tejo, Rodrigo; Morales, Danna; Varela, Diego; Millas-Vargas, Juan Pablo; Retamal (Nature Publishing Group, 2018)
      © 2018, The Author(s).Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking ...
    • In Vitro-generated Tc17 cells Present a Memory Phenotype and serve as a reservoir of Tc1 cells In Vivo 
      Flores Santibañez, Felipe; Cuadra, Barbara; Fernández, Dominique; Rosemblatt, María V.; Nunez, Sarah; Cruz, Pablo; Gálvez Cancino, Felipe Ignacio; Cárdenas, J.C.; Lladser, Álvaro; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Frontiers Media SA, 2018)
      Memory CD8(+) T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8(+) T cell effector ...
    • K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and ... 
      Canales, Jimena; Cruz, Pablo; Villacura Díaz, Nicolás Esteban; Riquelme, Denise; Leiva Salcedo, Elias; Cerda Arancibia, Óscar (MDPI, 2020)
      Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases, Rho-GTPases proteins, and Ca2+ signaling. Interestingly, ubiquitination ...