Now showing items 1-5 of 5

    • Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation 

      Torrealba, Natalia; Navarro Márquez, Mario F.; Vega Garrido, Valeria; Pedrozo Cibils, Zully; Romero, Diego; Eura, Yuka; Villalobos, Elisa; Carlos Roa, Juan; Chiong Lay, Mario; Kokame, Koichi; Lavandero González, Sergio (Nature Publishing Group, 2017)
      Cardiac hypertrophy is an adaptive response triggered by pathological stimuli. Regulation of the synthesis and the degradation of the Ca2+ channel inositol 1,4,5-trisphosphate receptor (IP3R) affects progression to cardiac ...
    • New Molecular Insights of Insulin in Diabetic Cardiomyopathy 

      Westermeier, Francisco; Riquelme, Jaime A.; Pavez, Mario; Garrido, Valeria; Díaz, Ariel; Verdejo, Hugo E.; Castro, Pablo F.; García Nannig, Lorena; Lavandero González, Sergio (Frontiers Media S.A., 2016-04)
      Type 2 diabetes mellitus (T2DM) is a highly prevalent disease worldwide. Cardiovascular disorders generated as a consequence of T2DM are a major cause of death related to this disease. Diabetic cardiomyopathy (DCM) is ...
    • Novel therapies targeting cardioprotection and regeneration 

      Garrido, Valeria; Mendoza Torres, Evelyn; Riquelme, Jaime A.; Díaz, Ariel; Pizarro, Marcela; Bustamante, Mario; Chávez, Myra N.; Ocaranza, María Paz; Mellado, Rosemarie; Corbalán, Ramón; Allende Connelly, Miguel; Lavandero González, Sergio (Bentham Science Publishers, 2017)
      Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium directly, such as myocardial infarction and consequent heart failure, as well as conditions ...
    • Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease 

      Bravo Sagua, Roberto; Parra Ortiz, Valentina; Muñoz Córdova, Felipe; Sánchez Aguilera, Pablo; Garrido, Valeria; Contreras Ferrat, Ariel; Chiong Lay, Mario; Lavandero González, Sergio (Elsevier, 2020)
      The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular ...