Now showing items 1-3 of 3

    • Independent Anti-Angiogenic Capacities of Coagulation Factors X and Xa 

      Lange, Soledad; Gonzalez, Ibeth; Pinto, Mauricio P.; Arce, Maximiliano; Valenzuela, Rodrigo; Aranda, Evelyn; Elliot, Matias; Alvarez, Marjorie; Henriquez, Soledad; Velasquez, Ethel V.; Orge, Felipe; Oliva, Barbara; Gonzalez, Pamela; Villalon, Manuel; Cautivo, Kelly M.; (Wiley-Liss Inc., 2014)
      Knockout models have shown that the coagulation system has a role in vascular development and angiogenesis. Herein, we report for the first time that zymogen FX and its active form (FXa) possess anti-angiogenic properties. ...
    • Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1 

      Diaz, Jorge; Aranda, Evelyn; Henriquez, Soledad; Quezada, Marisol; Espinoza, Estefanía; Bravo, Maria Loreto; Oliva, Bárbara; Lange, Soledad; Villalon, Manuel; Jones, Marius; Brosens, Jan J.; Kato, Sumie; Cuello, Mauricio A.; Knutson, Todd P.; Lange, Carol A.; Leyton, Li (2012)
      Progesterone and progestins have been demonstrated to enhance breast cancer cell migration, although the mech- anisms are still not fully understood. The protease-activated receptors (PARs) are a family of membrane receptors ...
    • Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and these effects are inhibited by TFPI 

      Henríquez, Soledad; Calderón, Claudia; Quezada, Marisol; Oliva, Bárbara; Bravo, Maria Loreto; Aranda, Evelyn; Kato, Sumie; Cuello, Mauricio A.; Gutiérrez, Jorge; Quest, Andrew F. G.; Owen, Gareth I. (2011)
      Tissue factor (TF) serving as the receptor for coagulation factor VII (FVII) initiates the extrinsic coagulation pathway. We previously demonstrated that progesterone increases TF, coagulation and invasion in breast cancer ...