Now showing items 1-6 of 6

    • Cárdenas, César; Lovy, Alenka; Silva Pavéz, Eduardo; Urra Faúndez, Félix; Mizzoni, Craig; Ahumada Castro, Ulises; Bustos, Galdo; Jaña, Fabián; Cruz, Pablo; Farías, Paula; Mendoza, Elizabeth; Huerta, Hernán; Murgas, Paola; Hunter, Martín; Ríos, Melany; Cerda Arancibia, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgó, Jordi; Foskett, James Kevin (AAAS. American Association for the Advancement of Science, 2020)
      Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ...
    • Bustos, Galdo; Cruz, Pablo; Lovy, Alenka; Cárdenas Matus, Julio (Frontiers media SA, 2017)
      Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to ...
    • Urra, Félix A.; Hernández Muñoz, Felipe Andrés; Córdova Delgado, Miguel; Ramírez, María Paz; Peña Ahumada, Bárbara; Rios, Melany; Cruz, Pablo; Ahumada-Castro, Ulises; Bustos, Galdo; Silva-Pavez, Eduardo; Pulgar Tejo, Rodrigo; Morales, Danna; Varela, Diego; Millas-Vargas, Juan Pablo; Retamal (Nature Publishing Group, 2018)
      © 2018, The Author(s).Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking ...
    • Carreras-Sureda, Amado; Jaña, Fabián; Urra, Hery; Durand, Sylvere; Mortenson, David E.; Sagredo, Alfredo; Bustos, Galdo; Hazari, Younis; Ramos-Fernández, Eva; Sassano, Maria L.; Pihán, Philippe; van Vliet, Alexander R.; González-Quiroz, Matías; Torres, Angie K.; Tapia- (Nature Publishing Group, 2019)
      Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected ...
    • Carreras-Sureda, Amado; Jaña, Fabián; Urra, Hery; Durand, Sylvere; Mortenson, David E.; Sagredo, Alfredo; Bustos, Galdo; Hazari, Younis; Ramos-Fernández, Eva; Sassano, Maria L.; Pihán, Philippe; van Vliet, Alexander R.; González-Quiroz, Matías; Torres, Angie K.; Tapia- (Nature Publishing Group, 2019)
      An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    • Cárdenas, César; Müller, Marioly; McNeal, Andrew; Lovy, Alenka; Jaňa, Fabian; Bustos, Galdo; Urra, Felix; Smith, Natalia; Molgó, Jordi; Diehl, J. Alan; Ridky, Todd W.; Foskett, J. Kevin (Elsevier B.V., 2016)
      © 2016 The Authors.In the absence of low-level ER-to-mitochondrial Ca2+ transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we ...