Now showing items 1-7 of 7

    • Evaluation of Antioxidant and Antitrypanosomal Properties of a Selected Series of Synthetic 3-Carboxamidocoumarins 

      Muñoz, Andrea; Fonseca, André; Matos, Maria J.; Uriarte, Eugenio; Santana, Lourdes; Borges, Fernanda; Figueroa, Roberto; Olea Azar, Claudio (Wiley-Blackwell, 2016)
      © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Oxidative stress is involved in several parasitic diseases such as Chagas. Agents able to selectively modulate biochemical processes involved in the disease represent ...
    • Evaluation of trypanocidal and antioxidant activities of a selected series of 3-amidocoumarins 

      Moncada-Basualto, Mauricio; Lapier, Michel; Maya Arango, Juan; Matsuhiro, Betty; Olea Azar, Claudio; Delogu, Giovanna; Uriarte, Eugenio; Santana, Lourdes; João Matos, María (Bentham Science, 2018)
      Background: Neglected diseases are becoming more prevalent due to globalization. This has inspired active research in the development of new drugs for the treatment of parasitic diseases such as Chagas disease. Objectives: ...
    • Facing chagas' disease: Trypanocidal properties of new coumarinchalcone scaffolds 

      Vázquez Rodríguez, Saleta; Guíñez, Roberto F.; Matos, Maria J.; Olea Azar, Claudio; Maya Arango, Juan; Uriarte, Eugenio; Santana, Lourdes (Bentham Science Publishers B.V., 2016)
      © 2016 Bentham Science Publishers. With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds ...
    • Interest of antioxidant agents in parasitic diseases. The case study of coumarins 

      Figueroa-Guiñez, Roberto; Matos, Maria João; Vazquez Rodriguez, Saleta; Santana, Lourdes; Uriarte, Eugenio; Borges, Fernanda; Olea Azar, Claudio; Maya Arango, Juan (Bentham Science Publishers B.V., 2015)
      © 2015 Bentham Science Publishers. Tropical parasitic diseases, especially those produced by protozoan parasites, are a major public health problem in many countries, and their impact in the health burden is significant. ...
    • Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins 

      Matos, Maria João; Pérez Cruz, Fernanda; Vazquez Rodriguez, Saleta; Uriarte, Eugenio; Santana, Lourdes; Borges, Fernanda; Olea Azar, Claudio (Elsevier, 2013)
      In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical ...
    • Synthesis and electrochemical and biological studies of novel coumarin-chalcone hybrid compounds 

      Pérez Cruz, Fernanda; Vazquez Rodriguez, Saleta; Matos, Maria João; Herrera Morales, Alejandra; Villamena, Frederick A.; Das, Amlan; Gopalakrishnan, Bhavani; Olea Azar, Claudio; Santana, Lourdes; Uriarte, Eugenio (2013)
      A series of novel hydroxy-coumarin-chalcone hybrid compounds 2a-i has been synthesized by employing a simple and efficient methodology. An electrochemical characterization using cyclic voltammetry and ESR spectroscopy were ...
    • Synthesis, antioxidant and antichagasic properties of a selected series of hydroxy-3-arylcoumarins 

      Robledo O'Ryan, Natalia Carolina; Moncada-Basualto, Mauricio; Mura, Francisco; Olea Azar, Claudio; Matos, Maria João; Vazquez-Rodriguez, Saleta; Santana, Lourdes; Uriarte, Eugenio; ; Lapier, Michel; Maya Arango, Juan (Elsevier Ltd, 2017)
      © 2016 Elsevier Ltd Oxidative stress is involved in several parasitic diseases such as Chagas. Agents able to selectively modulate biochemical processes involved in the disease represent promising multifunctional agents ...