Browsing by Author "66681109-881b-4ff5-b37c-0d871065abe7"

Now showing items 1-13 of 13

    • Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients 
      Bravo, Dalibel; Salduz, Ahmet; Shogren, Kristen L.; Okuno, Madison N.; Herrick, James L.; Okuno, Scott H.; Galindo, Mario A.; van Wijnen, Andre J.; Yaszemski, Michael J.; Maran, Avudaiappan (Elsevier B.V., 2018)
      © 2018 Osteosarcoma is a malignant bone tumor that occurs mainly in children and adolescents. Because Wnt signaling has been implicated in the pathogenesis of osteosarcoma, we have investigated the circulating and local ...
    • Dickkopf-1 reduces hypertrophic changes in human chondrocytes derived from bone marrow stem cells 
      Rojas, Andrea; Mardones, Rodrigo; Pritzker, Kenneth; van Wijnen, Andre J.; Galindo, Mario A.; Las Heras, Facundo (Elsevier B.V., 2019)
      © 2018The in vitro process of chondrogenic differentiation of mesenchymal stem cells (MSCs) induces a pre-apoptotic hypertrophic phenotype, guided by the active status of the WNT/β‑catenin pathway. To achieve a stable ...
    • Extracellular vesicles from osteosarcoma cell lines contain miRNAs associated with cell adhesion and apoptosis 
      Jerez, Sofía; Araya, Héctor; Hevia, Daniel; Irarrázaval, Carlos E.; Thaler, Roman; van Wijnen, Andre J.; Galindo, Mario A. (Elsevier B.V., 2019)
      Osteosarcoma is the most common primary bone tumor during childhood and adolescence. Several reports have presented data on serum biomarkers for osteosarcoma, but few reports have analyzed circulating microRNAs (miRNAs). ...
    • Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation 
      Khani, Farzaneh; Thaler, Roman; Paradise, Christopher R.; Deyle, David R.; Kruijthof-de Julio, Marianne; Galindo, Mario A.; Gordon, Jonathan A.; Stein, Gary S.; Dudakovic, Amel; van Wijnen, Andre J. (Wiley-Liss Inc., 2017)
      © 2016 Wiley Periodicals, Inc. Osteogenic lineage commitment and progression is controlled by multiple signaling pathways (e.g., WNT, BMP, FGF) that converge on bone-related transcription factors. Access of osteogenic ...
    • Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfβ in ... 
      San Martin, Inga A.; Varela, Nelson; Gaete, Marcia; Villegas, Karina; Osorio, Mariana; Tapia, Julio; Antonelli, Marcelo; Mancilla, Edna E.; Pereira, Barry P.; Nathan, Saminathan S.; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; Van Wijnen, Andre J.; Galindo, Mario A. (2009)
      Bone formation and osteoblast differentiation require the functional expression of the Runx2/Cbfβ heterodimeric transcription factor complex. Runx2 is also a suppressor of proliferation in osteoblasts by attenuating cell ...
    • Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells 
      Mamo, Tewodros; Mladek, Ann C.; Shogren, Kris L.; Gustafson, Carl; Gupta, Shiv K.; Riester, Scott M.; Maran, Avudaiappan; Galindo, Mario A.; van Wijnen, Andre J.; Sarkaria, Jann N.; Yaszemski, Michael J. (Elsevier B.V., 2017)
      © 2017 Elsevier Inc. Osteosarcoma survival rate has not improved over the past three decades, and the debilitating side effects of the surgical treatment suggest the need for alternative local control approaches. Radiotherapy ...
    • Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2 
      Young, Daniel W.; Hassan, Mohammad Q.; Yang, Xiao Qing; Galindo, Mario A.; Javed, Amjad; Zaidi, Sayyed K.; Furcinitti, Paul; Lapointe, David; Montecino, Martín; Lian, Jane B.; Stein, Janet L.; Van Wijnen, Andre J.; Stein, Gary S. (2007)
      During cell division, cessation of transcription is coupled with mitotic chromosome condensation. A fundamental biological question is how gene expression patterns are retained during mitosis to ensure the phenotype of ...
    • Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 ... 
      Rojas, Adriana; Sepúlveda, Hugo; Henríquez, Berta; Aguilar, Rodrigo; Opazo, Tatiana; Nardocci, Gino; Bustos, Fernando; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; van Zundert, Brigitte; van Wijnen, Andre J.; Allende Connelly, Miguel; Montecino, Martín (Wiley, 2019)
      Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been identified, the epigenetic ...
    • Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus 
      López Aguilar, Rodrigo; Bustos, Fernando J.; Sáez, Mauricio; Rojas, Adriana; Allende Connelly, Miguel; van Wijnen, Andre J.; van Zundert, Brigitte; Montecino, Martín (Elsevier, 2016)
      During hippocampal neuron differentiation, the expression of critical inducers of non-neuronal cell lineages must be efficiently silenced. Runx2 transcription factor is the master regulator of mesenchymal cells responsible ...
    • Proteomic Analysis of Exosomes and Exosome-Free Conditioned Media From Human Osteosarcoma Cell Lines Reveals ... 
      Jerez, Sofía; Toledo Araya, Héctor; Thaler, Roman; Charlesworth, M. Cristine; López-Solís, Remigio; Kalergis, Alexis M.; Céspedes, Pablo F.; Dudakovic, Amel; Stein, Gary S.; van Wijnen, Andre J.; Galindo, Mario A. (Wiley-Liss Inc., 2017)
      © 2016 Wiley Periodicals, Inc.Osteosarcomas are the most prevalent bone tumors in pediatric patients, but can also occur later in life. Bone tumors have the potential to metastasize to lung and occasionally other vital ...
    • Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors 
      Teplyuk, Nadiya M.; Galindo, Mario A.; Teplyuk, Viktor I.; Pratap, Jitesh; Young, Daniel W.; Lapointe, David; Javed, Amjad; Stein, Janet L.; Lian, Jane B.; Stein, Gary S.; Van Wijnen, Andre J. (2008)
      Runt-related transcription factor 2 (Runx2) controls lineage commitment, proliferation, and anabolic functions of osteoblasts as the subnuclear effector of multiple signaling axes (e.g. transforming growth factor-β/BMP-SMAD, ...
    • Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation ... 
      Pereira, Barry P.; Zhou, Yefang; Gupta, Anurag; Leong, David T.; Aung, Khin Zarchi; Ling, Ling; Pho, Robert W.H.; Galindo, Mario A.; Salto-Tellez, Manuel; Stein, Gary S.; Cool, Simon M.; Van Wijnen, Andre J.; Nathan, Saminathan S. (2009)
      Osteosarcomas are the most prevalent primary bone tumors found in pediatric patients. To understand their molecular etiology, cell culture models are used to define disease mechanisms under controlled conditions. Many ...
    • Wnt/β catenin signaling activates expression of the bone-related transcription factor RUNX2 in select human ... 
      Vega, Oscar A.; Lucero, Claudia M. J.; Araya, Héctor F.; Jerez, Sofía; Tapia Pineda, Julio; Antonelli Anativia, Juan; Salazar Onfray, Flavio; Heras Aliciardi, Facundo las; Thaler, Roman; Riester, Scott M.; Stein, Gary S.; van Wijnen, Andre J.; Galindo Díaz, Mario (Wiley, 2017)
      Osteosarcoma is the most common malignant bone tumor in children and adolescents. Metastasis and poor responsiveness to chemotherapy in osteosarcoma correlates with over-expression of the runt-related transcription factor ...