Browsing by Author "70e76f71-af62-4679-9988-e9eb673a61d1"

Now showing items 1-20 of 20

    • A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis 
      Díaz Jiménez, David; Núñez, Lucía; Fuente, Marjorie de la; Dubois Camacho, Karen; Sepulveda, Hugo; Montecino, Martin; Torres Riquelme, Alejandro; García González, Paulina; Chnaiderman Figueroa, Jonás; Vossenkamper, Anna; MacDonald, Thomas T.; Simian, Daniela; González Burgos, María Julieta; Cidlowski, John A.; Quera Pino, Rodrigo; Hermoso Ramello, Marcela (Nature Publishing Group, 2017)
      The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) ...
    • Aberrant localization of ezrin correlates with salivary acini disorganization in Sjogren's Syndrome. 
      Pérez, Paola; Aguilera, Sergio; Olea, Nancy; Alliende, Cecilia; Molina, Claudio; Brito, Mónica; Barrera, María José; Leyton, Cecilia; Rowzee, Anne; González Burgos, María Julieta (2010)
      To analyse whether the alterations in the structure and organization of microvilli in salivary acinar cells from SS patients are linked to changes in the expression and/or cellular localization of ezrin. Salivary gland ...
    • Aberrant MUC1 accumulation in salivary glands of Sjogren's syndrome patients is reversed by TUDCA in vitro 
      Castro Masso, Isabel; Albornoz, Nicolás; Aguilera, Sergio; Barrera, María José; González, Sergio; Núñez, Matilde; Carvajal, Patricia; Jara, Daniela; Lagos, Carolina; Molina, Claudio; Urzúa Tobar, Ulises; Hermoso, Marcela; González Burgos, María Julieta (Oxford University Press, 2020)
      Objectives. Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate ...
    • Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and ... 
      Lagos, Carolina; Carvajal, Patricia; Castro, Isabel; Jara, Daniela; González, Sergio; Aguilera, Sergio; Barrera, María José; Quest, Andrew F. G.; Bahamondes, Verónica; Molina, Claudio; Urzúa, Ulises; Hermoso Ramello, Marcela; Leyton, Cecilia; González Burgos, María Julieta (Academic Press Inc., 2018)
      © 2018 Elsevier Inc.Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial ...
    • Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjögren's ... 
      Molina, C.; Alliende, C.; Aguilera, S.; Kwon, Y. J.; Leyton, L.; Martínez, B.; Leyton, C.; Pérez, P.; González Burgos, María Julieta (2006)
      Objective: To study the expression of laminin and type IV collagen as biomarkers of the organisation of the basal lamina of acini and ducts in labial salivary glands from patients with Sjögren's syndrome, and to relate ...
    • Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated ... 
      Bahamondes, Verónica; Albornoz, Amelina; Aguilera, Sergio; Alliende, Cecilia; Molina, Claudio; Castro, Isabel; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Barrera, María José; González, Sergio; Sánchez, Marianela; Härtel, Steffen; Hermoso Ramello, Marcela; Leyton Martínez, Cecilia; González Burgos, María Julieta (WILEY-BLACKWELL, 2011-10)
      Objective. Oral and ocular dryness are frequent and serious symptoms of Sjogren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process in the secretory pathway, ...
    • Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease 
      Beltrán, Caroll J.; Núñez, Lucía E.; Díaz Jiménez, David; Farfán, Nancy; Candia, Enzo; Heine, Claudio; López, Francisco; González Burgos, María Julieta; Quera Pino, Rodrigo; Hermoso Ramello, Marcela (2010)
      Background: ST2 has been proposed to be a regulator of inflammation and Th1/Th2 balance. ST2L is the IL-33 membrane receptor and belongs to the IL-1R family. The soluble variant, ST2s, is identical to the extracellular ...
    • Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in ... 
      Castro, Isabel; Aguilera, Sergio; Brockhausen, Inka; Alliende, Cecilia; Quest, Andrew F. G.; Molina, Claudio; Urzúa Tobar, Ulises; Mandel, Ulla; Bahamondes, Verónica; Barrera, María José; Sánchez, Marianela; González, Sergio; Hermoso Ramello, Marcela; Leyton Martínez, Cecilia; González Burgos, María Julieta (Oxford University Press, 2012)
      Objectives. To determine the expression and enzymatic activities of sulphotransferases involved in mucin hyposulphation in labial salivary glands (LSGs) from SS patients and to correlate sulphotransferase activity with ...
    • Diabetes alters the involvement of myofibroblasts during periodontal wound healing 
      Retamal, Ignacio; Hernández, Romina; Velarde, Victoria; Oyarzún, Alejandro; Martínez, Constanza; González Burgos, María Julieta; Martínez Winkler, Jorge; Smith, Patricio C. (Wiley, 2020)
      Objectives Myofibroblasts constitute a specific cell phenotype involved in connective tissue healing. Diabetes alters the wound healing response. However, it is not clear whether diabetes modifies the involvement of ...
    • Gene expression and chromosomal location for susceptibility to Sjögren's syndrome 
      Pérez, Paola; Anaya, Juan Manuel; Aguilera, Sergio; Urzúa Tobar, Ulises; Munroe, David; Molina, Claudio; Hermoso Ramello, Marcela; Cherry, James Michael; Alliende, Cecilia; Olea, Nancy; Ruiz-Narváez, Edward; González Burgos, María Julieta (2009)
      Primary Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease affecting mainly the exocrine glands. Its physio-pathology is poorly understood and most of the knowledge has been related to the inflammatory ...
    • Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured ... 
      Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • HSA-MIR-513C-3P overexpression decreases XBP-1S correlating with increased inflammation and autoantibodies ... 
      Carvajal, Patricia; Aguilera, Sergio; Heathcote, Bernard; Castro Masso, Isabel; Jara, Daniela; Barrera, María José; Maracajá Coutinho, Vinicius; González, S.; Aliaga, Vanina; Molina, Claudio; González Burgos, María Julieta (BMJ, 2020)
    • Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary ... 
      Kwon, Yoon Jeoung; Pérez, Paola; Aguilera, Sergio; Molina, Claudio; Leyton Campos, Lisette; Alliende, Cecilia; Leyton, Cecilia; Brito, Mónica; Romo, Rafael; González Burgos, María Julieta (2006)
      Objective. To investigate remodeling of the basal lamina of labial salivary glands (LSGs) from patients with Sjögren's syndrome (SS) by analyzing the expression of specific components that participate in its assembly and ...
    • Matrix metalloproteinase 9 in the saliva of patients with Sjögren's syndrome: Comment on the article by ... 
      Konttinen, Yrjö T.; Azuma, M.; González Burgos, María Julieta; Covarrubias, Sergio Aguilera; Castillo, Claudio Molina; Campos, Lisette Leyton (2004)
    • Mechanotransduction and epigenetic control in autoimmune diseases 
      González, Sergio; Aguilera, Sergio; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Molina, Claudio; Alliende, Cecilia; Hermoso Ramello, Marcela; González Burgos, María Julieta (Elsevier, 2011)
      Differentiation of epithelial cells is required to define tissue architecture and appropriate function of these cells is associated with a specific pattern of gene expression. DNA methylation, post-translational modification ...
    • MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome 
      Sung Hsieh, Hsiao; Castro, I.; González, S.; Aguilera, S.; Smorodinsky, N. I.; Quest, Andrew F. G.; Bahamondes Lorca, Verónica; Alliende, Cecilia; Cortés, J.; Molina, Claudio; Urzúa Tobar, Ulises; Barrera, María José; Hermoso Ramello, Marcela; Herrera Cisterna, Luisa; Leyton Martínez, Cecilia; González Burgos, María Julieta (Wiley-Blackwell, 2015)
      OBJECTIVES: To evaluate the expression and localization of MUC1/SEC and MUC1/Y isoforms in labial salivary glands (LSG) from Sj€ogren’s syndrome patients (SS patients), as well as their in vitro expression induced by ...
    • Parity history determines a systemic inflammatory response to spread of ovarian cancer in naturally aged mice 
      Urzúa Tobar, Ulises; Chacón, Carlos; Lizama, Luis; Sarmiento, Sebastián; Villalobos, Pía; Kroxato, Belén; Marcelain Cubillos, Katherine; González Burgos, María Julieta (International Society on Aging and Disease, 2017)
      Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly ...
    • Phosphatidylinositol 3-kinase interacts with the glucocorticoid receptor upon TLR2 activation 
      Arancibia, Sergio; Benítez, Dixán; Núñez, Lucia E.; Jewell, Christine M.; Langjahr, Patricia; Candia, Enzo; Zapata Torres, Gerald; Cidlowski, John A.; González Burgos, María Julieta; Hermoso Ramello, Marcela (2011)
      Airway inflammation is a common condition where glucocorticoids (GC) are a well-established therapy. It has been demonstrated that GC stimulate components of innate immunity. Specifically, GC up-regulate TLR2 expression ...
    • Soluble ST2 is a sensitive clinical marker of ulcerative colitis evolution 
      Díaz Jiménez, David; De la Fuente, Marjorie; Dubois Camacho, Karen; Landskron, Glauben; Fuentes, Janitza; Pérez, Tamara; González Burgos, María Julieta; Simian, Daniela; Hermoso Ramello, Marcela; Quera Pino, Rodrigo (2016)
      Background: The ST2/IL-33 pathway has been related to ulcerative colitis (UC), and soluble ST2 (sST2), to disease severity. We tested the potential usefulness of sST2 as a predictive marker of treatment response and patients' ...
    • Soluble ST2: A new and promising activity marker in ulcerative colitis 
      Díaz Jiménez, David; Núñez, Lucía E.; Beltrán, Caroll J.; Candia, Enzo; Suazo, Cristóbal; Álvarez Lobos, Manuel; González Burgos, María Julieta; Hermoso Ramello, Marcela; Quera Pino, Rodrigo (2011)
      AIM: To correlate circulating soluble ST2 (sST2) levels with the severity of ulcerative colitis (UC) and serum levels of pro-inflammatory cytokines, and to demonstrate the predictive power of sST2 levels for differentiation ...