Now showing items 1-20 of 21

    • Agreements between Industry and Academia on Publication Rights: A Retrospective Study of Protocols and Publications of Randomized Clinical Trials 

      Kasenda, Benjamín; von Elm, Erik; You, John J.; Bluemle, Anette; Tomonaga, Yuki; Saccilotto, Ramón; Amstutz, Alain; Bengough, Theresa; Meerpohl, Joerg J.; Stegert, Mihaela; Olu, Kelechi K.; Tikkinen, Kari; Neumann, Ignacio; Carrasco Labra, Raúl; Faulhaber, Markus; Mulla, Sohail M.; Mertz, Dominik; Akl, Elie A.; Bassler, Dirk; Busse, Jason W.; Ferreira González, Ignacio; Lamontagne, Francois; Nordmann, Alain; Gloy, Viktoria; Raatz, Heike; Moja, Lorenzo; Ebrahim, Shanil; Schandelmaier, Stefan; Sun, Xin; Vandvik, Per O.; Johnston, Bradley C.; Walter, Martín A.; Burnand, Bernard; Schwenkglenks, Matthias; Hemkens, Lars G.; Bucher, Heiner C.; Guyatt, Gordon H.; Briel, Matthias (Public Library Science, 2016)
      Background Little is known about publication agreements between industry and academic investigators in trial protocols and the consistency of these agreements with corresponding statements in publications. We aimed to ...
    • Authors seldom report the most patient-important outcomes and absolute effect measures in systematic review abstracts 

      Agarwal, Arnav; Johnston, Bradley C.; Vernooij, Robin W.M.; Carrasco Labra, Alonso; Brignardello Petersen, Romina; Neumann, Ignacio; Akl, Elie A; Sun, Xin; Briel, Matthias; Busse, Jason W.; Ebrahim, Shanil; Granados, Carlos E.; Iorio, Alfonso; Irfan, Affan; Martínez G (Elsevier USA, 2017)
      © 2016 Elsevier Inc. Objectives Explicit reporting of absolute measures is important to ensure treatment effects are correctly interpreted. We examined the extent to which authors report absolute effects for patient-important ...
    • Comparison between the standard and a new alternative format of the Summary-of-Findings tables in Cochrane review users: study protocol for a randomized controlled trial 

      Carrasco Labra, Alonso; Brignardello Petersen, Romina; Santesso, Nancy; Neumann, Ignacio; Mustafa, Reem; Mbuagbaw, Lawrence; Etxeandia Ikobaltzeta, Itziar; De Stio, Catherine; McCullagh, Lauren; Alonso Coello, Pablo; Meerpohl, Joerg; Vandvik, Per Olav; Brozek, Jan; Akl, Elie; Bossuyt, Patrick; Churchill, Rachel; Glenton, Claire; Rosenbaum, Sarah; Tugwell, Peter; Welch, Vivian; Guyatt, Gordon H.; Schuenemann, Holger (BIOMED CENTRAL, 2015)
      Background: Systematic reviews represent one of the most important tools for knowledge translation but users often struggle with understanding and interpreting their results. GRADE Summary-of-Findings tables have been ...
    • Completion and Publication Rates of Randomized Controlled Trials in Surgery An Empirical Study 

      Rosenthal, Rachel; Kasenda, Benjamin; Dell-Kuster, Salome; Elm, Erik von; You, John; Bluemle, Anette; Tomonaga, Yuki; Saccilotto, Ramón; Amstutz, Alain; Bengough, Theresa; Meerpohl, Joerg J.; Stegert, Mihaela; Tikkinen, Kari A. O.; Neumann, Ignacio; Carrasco Labra, Alonso; Faulhaber, Markus; Sohail, Mulla; Mertz, Dominik; Akl, Elie A.; Bassler, Dirk; Busse, Jason W.; Ferreira González, Ignacio; Lamontagne, Francois; Nordmann, Alain; Gloy, Viktoria; Olu, Kelechi K.; Raatz, Heike; Moja, Lorenzo; Ebrahim, Shanil; Schandelmaier, Stefan; Sun, Xin; Vandvik, Per O.; Bradley C., Johnston; Walter, Martin A.; Burnand, Bernard; Schwenkglenks, Matthias; Hemkens, Lars G.; Bucher, Heiner C.; Guyatt, Gordon H.; Briel, Matthias (Lippicott Williams & Wilkins, 2015)
      Objective: To investigate the prevalence of discontinuation and nonpublication of surgical versus medical randomized controlled trials (RCTs) and to explore risk factors for discontinuation and nonpublication of surgical ...
    • Do clinicians want recommendations? A multicenter study comparing evidence summaries with and without GRADE recommendations 

      Neumann, Ignacio; Alonso Coello, Pablo; Vandvik, Per; Agoritsas, Thomas; Mas, Gemma; Akl, Elie; Brignardello Petersen, Romina; Emparanza, José; McCullagh, Lauren; De Sitio, Catherine; McGinn, Thomas; Almodaimegh, Hind; Almodaimegh, Khalid; Rivera, Solange; Rojas, Luis; Stirnemann, Jérôme; Irani, Jihad; Hlais, Sani; Mustafa, Reem; Bdair, Fadi; Aly, Abdelrahman; Kristiansen, Annette; Izcovich, Ariel; Ramírez Morera, Anggie; Brozek, Jan; Guyatt, Gordon H.; Schünemann, Holger (Elsevier, 2018-07)
      Objectives: Evidence-based clinical practice guidelines provide recommendations to assist clinicians in decision-making and to reduce the gap between best current research evidence and clinical practice. However, some argue ...
    • Do clinicians want recommendations? A multicenter study comparing evidence summaries with and without GRADE recommendations 

      Neumann, Ignacio; Alonso Coello, Pablo; Vandvik, Per Olav; Agoritsas, Thomas; Mas, Gemma; Akl, Elie A; Brignardello Petersen, Romina; Emparanza, Jose; McCullagh, Lauren; De Sitio, Catherine; McGinn, Thomas; Almodaimegh, Hind; Almodaimegh, Khalid; Rivera, Solange; Roja (Elsevier USA, 2018)
      © 2018 Elsevier Inc. Objectives: Evidence-based clinical practice guidelines provide recommendations to assist clinicians in decision-making and to reduce the gap between best current research evidence and clinical practice. ...
    • The GRADE approach is reproducible in assessing the quality of evidence of quantitative evidence syntheses 

      Mustafa, Reem A.; Santesso, Nancy; Brozek, Jan; Akl, Elie A.; Walter, Stephen D.; Norman, Geoff; Kulasegaram, Mahan; Christensen, Robin; Guyatt, Gordon H.; Falck Ytter, Yngve; Chang, Stephanie; Hassan Murad, Mohammad; Vist, Gunn E.; Lasserson, Toby; Gartlehner, Gerald; Shukla, Vijay; Sun, Xin; Whittington, Craig; Post, Piet N.; Lang, Eddy; Thaler, Kylie; Kunnamo, Ilkka; Alenius, Heidi; Meerpohl, Joerg J.; Alba, Ana C.; Nevis, Immaculate F.; Gentles, Stephen; Ethier, Marie Chantal; Carrasco Labra, Raúl; Khatib, Rasha; Nesrallah, Gihad; Kroft, Jamie; Selk, Amanda; Brignardello Petersen, Romina; Schünemann, Holger J. (Elsevier, 2013)
      Objective: We evaluated the inter-rater reliability (IRR) of assessing the quality of evidence (QoE) using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Study Design and Setting: ...
    • GRADE equity guidelines 2: considering health equity in GRADE guideline development: equity extension of the guideline development checklist 

      Akl, Elie A.; Welch, Vivian; Pottie, Kevin; Eslava Schmalbach, Javier; Darzi, Andrea; Sola, Ivan; Katikireddi, Srinivasa Vittal; Singh, Jasvinder; Murad, M. Hassan; Meerpohl, Joerg; Stanev, Roger; Lang, Eddy; Matovinovic, Elizabeth; Shea, Beverley; Agoritsas, Thomas; Alexander, Paul E.; Snellman, Alexandra; Brignardello Petersen, Romina; Gloss, David; Thabane, Lehana; Shi, Chunhu; Stein, Airton T.; Sharaf, Ravi; Brier, Matthias; Guyatt, Gordon H.; Schunemann, Holger; Tugwell, Peter (Elsevier, 2017)
      Objective: To provide guidance for guideline developers on how to consider health equity at key stages of the guideline development process. Study Design and Setting: Literature review followed by group discussions and ...
    • GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 1: Introduction 

      Alonso Coello, Pablo; Schunemann, Holger J.; Moberg, Jenny; Brignardello Petersen, Romina; Akl, Elie A; Davoli, Marina; Treweek, Shaun; Mustafa, Reem A.; Rada, Gabriel; Rosenbaum, Sarah; Morelli, Angela; Guyatt, Gordon H.; Oxman, Andrew D. (BMJ Publishing, 2016)
    • GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines 

      Alonso Coello, Pablo; Oxman, Andrew D.; Moberg, Jenny; Brignardello Petersen, Romina; Akl, Elie A.; Davoli, Marina; Treweek, Shaun; Mustafa, Reem A.; Vandvik, Per O.; Meerpohl, Joerg; Guyatt, Gordon H.; Schunemann, Holger J. (BMJ Publishing, 2016)
    • Improving GRADE evidence tables part 1: a randomized trial shows improved understanding of content in summary of findings tables with a new format 

      Carrasco Labra, Alonso; Brignardello Petersen, Romina; Santesso, Nancy; Neumann, Ignacio; Mustafa, Reem; Mbuagbaw, Lawrence; Etxeandia Ikobaltzeta, Itziar; De Stio, Catherine; McCullagh, Lauren; Alonso Coello, Pablo; Meerpohl, Joerg; Vandvik, Per; Brozek, Jan; Akl, Elie; Bossuyt, Patrick; Churchill, Rachel; Glenton, Claire; Rosenbaum, Sarah; Tugwell, Peter; Welch, Vivian; Garner, Paul; Guyatt, Gordon H.; Sch€unemann, Holger (Elsevier, 2016)
      Objectives: The current format of summary of findings (SoFs) tables for presenting effect estimates and associated quality of evidence improve understanding and assist users finding key information in systematic reviews. ...
    • Improving GRADE evidence tables part 3: detailed guidance for explanatory footnotes supports creating and understanding GRADE certainty in the evidence judgments 

      Santesso, Nancy; Carrasco Labra, Alonso; Langendam, Miranda; Brignardello Petersen, Romina; Mustafa, Reem; Heus, Pauline; Lasserson, Toby; Opiyo, Newton; Kunnamo, Ilkka; Sinclair, David; Garner, Paul; Treweek, Shaun; Tovey, David; Akl, Elie; Tugwell, Peter; Brozek, Jan; Guyatt, Gordon H.; Schunemann, Holger (Elsevier, 2016)
      Background: The Grading of Recommendations Assessment, Development and Evaluation (GRADE) is widely used and reliable and accurate for assessing the certainty in the body of health evidence. The GRADE working group has ...
    • Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol 

      Wu, Darong; Akl, Elie A.; Guyatt, Gordon H.; Devereaux, Philip J.; Brignardello Petersen, Romina; Prediger, Barbara; Patel, Krupesh; Patel, Namrata; Lu, Taoying; Zhang, Yuan; Falavigna, Maicon; Santesso, Nancy; Mustafa, Reem A.; Zhou, Qi; Briel, Matthias; Schünemann, Holger J. (BioMed Central Ltd., 2014)
      Background: Although even randomization (that is, approximately 1:1 randomization ratio in study arms) provides the greatest statistical power, designed uneven randomization (DUR), (for example, 1:2 or 1:3) is used to ...
    • Premature Discontinuation of Randomized Trials in Critical and Emergency Care: A Retrospective Cohort Study 

      Schandelmaier, Stefan; Elm, Erik von; You, John J.; Bluemle, Anette; Tomonaga, Yuki; Lamontagne, Francois; Saccilotto, Ramón; Amstutz, Alain; Bengough, Theresa; Meerpohl, Joerg J.; Stegert, Mihaela; Olu, Kelechi K.; Tikkinen, Kari A. O.; Neumann, Ignacio; Carrasco Labra, Alonso; Faulhaber, Markus; Mulla, Sohail M.; Mertz, Dominik; Akl, Elie A.; Sun, Xin; Bassler, Dirk; Busse, Jason W.; Ferreira González, Ignacio; Nordmann, Alain; Gloy, Viktoria; Raatz, Heike; Moja, Lorenzo; Rosenthal, Rachel; Ebrahim, Shanil; Vandvik, Per O.; Johnston, Bradley C.; Walter, Martin A.; Burnand, Bernard; Schwenkglenks, Matthias; Hemkens, Lars G.; Cook, Deborah J.; Meade, Maureen O.; Bucher, Heiner C.; Kasenda, Benjamin; Briel, Matthias (Lippicott Williams & Wilkins, 2016)
      Objectives: Randomized clinical trials that enroll patients in critical or emergency care (acute care) setting are challenging because of narrow time windows for recruitment and the inability of many patients to provide ...
    • Prevalence, Characteristics, and Publication of Discontinued Randomized Trials 

      Kasenda, Benjamin; Von Elm, Erik; You, John; Blümle, Anette; Tomonaga, Yuki; Saccilotto, Ramón; Amstutz, Alain; Bengough, Theresa; Meerpohl, Joerg J.; Stegert, Mihaela; Tikkinen, Kari A. O.; Neumann, Ignacio; Carrasco Labra, Alonso; Faulhaber, Markus; Mulla, Sohail M.; Mertz, Dominik; Akl, Elie A.; Bassler, Dirk; Busse, Jason W.; Ferreira González, Ignacio; Lamontagne, Francois; Nordmann, Alain; Gloy, Viktoria; Raatz, Heike; Moja, Lorenzo; Rosenthal, Rachel; Ebrahim, Shanil; Schandelmaier, Stefan; Xin, Sun; Vandvik, Per O.; Johnston, Bradley C.; Walter, Martin A.; Burnand, Bernard; Schwenkglenks, Matthias; Hemkens, Lars G.; Bucher, Heiner C.; Guyatt, Gordon H.; Briel, Matthias (American Medical Association., 2014)
      IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. The epidemiology of discontinued RCTs, however, remains unclear. OBJECTIVES To ...
    • Reporting missing participant data in randomised trials: systematic survey of the methodological literature and a proposed guide 

      Akl, Elie A; Shawwa, Khaled; Kahale, Lara A.; Agoritsas, Thomas; Brignardello Petersen, Romina; Busse, Jason W.; Carrasco Labra, Alonso; Ebrahim, Shanil; Johnston, Bradley C.; Neumann, Ignacio; Solà, Iván; Sun, Xin; Vandvik, Per; Zhang, Yuqing; Alonso Coello, Pablo; Guyatt, Gordon H. (BMJ Publishing Group, 2015)
      Objectives We conducted a systematic survey of the methodological literature to identify recommended approaches for how and what randomised clinical trial (RCT) authors should report on missing participant data and, on the ...
    • Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey 

      Akl, Elie A.; Carrasco Labra, Alonso; Brignardello Petersen, Romina; Neumann, Ignacio; Johnston, Bradley C.; Sun, Xin; Briel, Matthias; Busse, Jason W.; Ebrahim, Shanil; Granados, Carlos E.; Iorio, Alfonso; Irfan, Affan; Martínez García, Laura; Mustafa, Reem A.; Ramírez Morera, Anggie; Selva, Anna; Solà, Iván; Sanabria, Andrea Juliana; Tikkinen, Kari A. O.; Vandvik, Per O.; Vernooij, Robin W. M.; Zazueta, Oscar E.; Zhou, Qi; Guyatt, Gordon H.; Alonso Coello, Pablo (BMJ, 2015)
      Objectives: To describe how systematic reviewers are reporting missing data for dichotomous outcomes, handling them in the analysis and assessing the risk of associated bias. Methods: We searched MEDLINE and the Cochrane ...
    • Systematic reviews do not adequately report or address missing outcome data in their analyses: a methodological survey 

      Kahale, Lara; Diab, Batoul; Brignardello Petersen, Romina; Agarwal, Arnav; Mustafa, Reem; Kwong, Joey; Neumann, Ignacio; Li, Ling; Cruz Lopes, Luciane; Briel, Matthias; Busse, Jason; Lorio, Alfonso; Vandvik, Per Olav; Alexander, Paul; Guyatt, Gordon H.; Akl, Elie (Elsevier, 2018-03-02)
      Objectives: To describe how systematic review authors report and address categories of participants with potential missing outcome data of trial participants. Study Design and Setting: Methodological survey of systematic ...
    • Systematic reviews experience major limitations in reporting absolute effects 

      Alonso Coello, Pablo; Carrasco Labra, Alonso; Brignardello Petersen, Romina; Neumann, Ignacio; Akl, Elie; Vernooij, Robin; Johnston, Brad; Sun, Xin; Briel, Matthias; Busse, Jason; Ebrahim, Shanil; Granados, Carlos; Iorio, Alfonso; Irfan, Affan; Martínez García, Laura; Mustafa, Reem; Ramírez Morers, Anggie; Selva, Anna; Solà, Iván; Sanabria, Andrea; Tikkinen, Kari; Vandvik, Per; Zazueta, Oscar; Zhang, Yuqing; Zhou, Qi; Schünemann, Holger; Guyatt, Gordon H. (Elsevier, 2016)
      Objectives: Expressing treatment effects in relative terms yields larger numbers than expressions in absolute terms, affecting the judgment of the clinicians and patients regarding the treatment options. It is uncertain ...
    • The GRADE evidence to decision framework: a report of its testing and application in 15 international guideline panels 

      Neumann, Ignacio; Brignardello Petersen, Romina; Wiercioch, Wojtek; Carrasco Labra, Alonso; Cuello, Carlos; Akl, Elie A.; Mustafa, Reem A.; Al-Hazzani, Waleed; Etxeandia Ikobaltzeta, Itziar; Rojas, Maria Ximena; Falavigna, Maicon; Santesso, Nancy; Brozek, Jan; Iorio, Alfonso; Alonso Coello, Pablo; Schunemann, Holger J. (BIOMED Central, 2016)
      Background: Judgments underlying guideline recommendations are seldom recorded and presented in a systematic fashion. The GRADE Evidence-to-Decision Framework (EtD) offers a transparent way to record and report guideline ...