Now showing items 1-18 of 18

    • Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone 

      Rojas García, Pedro; Recabarren, Mónica P.; Sir Petermann, Lidia; Rey, Rodolfo; Palma, Sergio; Carrasco, Albert; Pérez Marín, Carlos; Padmanabhan, Vasantha; Recabarren, Sergio E. (Springer, 2013-06)
      The reprograming effects of prenatal testosterone (T) treatment on postnatal reproductive parameters have been studied extensively in females of several species but similar studies in males are limited. We recently found ...
    • Birth weight in offspring of mothers with polycystic ovarian syndrome 

      Sir Petermann, Lidia; Hitchsfeld, Catalina; Maliqueo Yevilao, Manuel; Codner Dujovne, Ethel; Echiburú López, Bárbara; Gazitúa Pepper, Raimundo; Recabarren, Sergio E.; Cassorla Goluboff, Fernando (OXFORD UNIV PRESS, GREAT CLARENDON ST, 2005-08)
      BACKGROUND: A relationship between reduced fetal growth and the polycystic ovary syndrome (PCOS) has been proposed in girls with PCOS. However, the birth weight in the offspring of PCOS mothers has not been systematically ...
    • Epigenética del síndrome de ovario poliquístico 

      Concha C., Francisca; Sir Petermann, Lidia; Recabarren, Sergio E.; Pérez Bravo, Fernando (Sociedad Médica de Santiago, 2017)
      Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features ...
    • Increased Anti-Müllerian Hormone Serum Concentrations in Prepubertal Daughters of Women with Polycystic Ovary Syndrome 

      Sir Petermann, Lidia; Codner Dujovne, Ethel; Maliqueo Yevilao, Manuel; Echiburú López, Bárbara; Hitchsfeld, Catalina; Crisosto King, Nicolás; Pérez Bravo, Francisco; Recabarren, Sergio E.; Cassorla Goluboff, Fernando (Oxford Press, 2006-10)
      CONTEXT: Anti-Müllerian hormone (AMH) is produced by the granulosa cells and reflects follicular development. Adult women with polycystic ovary syndrome (PCOS) have increased levels of AMH associated with an excessive ...
    • Increased anti-müllerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome 

      Sir Petermann, Teresa; Codner Dujovne, Ethel; Maliqueo Yevilao, Manuel; Echiburú López, Bárbara; Hitschfeld, Catalina; Crisosto King, Nicolás; Pérez Bravo, Francisco; Recabarren, Sergio E.; Cassorla Goluboff, Fernando (Endocrine Society, 2006)
      Context: Anti-Müllerian hormone (AMH) is produced by the granulosa cells and reflects follicular development. Adult women with polycystic ovary syndrome (PCOS) have increased levels of AMH associated with an excessive ...
    • La exposición prenatal a andrógenos como factor de reprogramación fetal 

      Recabarren, Sergio E.; Sir Petermann, Lidia; Maliqueo Yevilao, Manuel; Lobos, Alejandro; Rojas García, Pedro (2006)
      Both epidemiological and clinical evidence suggest a relationship between the prenatal environment and the risk of developing diseases during adulthood. The first observations about this relationship showed that prenatal ...
    • Metabolic profile in sons of women with polycystic ovary syndrome 

      Recabarren, Sergio E.; Smith, Rosita; Rios, Rafael; Maliqueo Yevilao, Manuel; Echiburú López, Bárbara; Codner Dujovne, Ethel; Cassorla Goluboff, Fernando; Rojas, Pedro; Sir Petermann, Teresa (Endocrine Society, 2008)
      Context: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder with strong familial aggregation. It has been demonstrated that parents and brothers of PCOS women exhibit insulin resistance and related ...
    • Metabolic profile in sons of women with polycystic ovary syndrome (PCOS) 

      Recabarren, Sergio E.; Smith Garcés, Rosita; Ríos, Rafael; Maliqueo Yevilao, Manuel; Echiburú López, Bárbara; Codner Dujovne, Ethel; Cassorla Goluboff, Fernando; Rojas, Pedro; Sir Petermann, Teresa (The Endocrine Society, 2008-01)
      Context: PCOS is an endocrine–metabolic disorder with familial aggregation. It has been demonstrated that parents and brothers of PCOS women exhibit insulin resistance and related metabolic defects. However, metabolic ...
    • Pituitary and Testicular Function in Sons of Women with Polycystic Ovary Syndrome from Infancy to Adulthood 

      Recabarren, Sergio E.; Sir Petermann, Lidia; Ríos, Rafael; Maliqueo Yevilao, Manuel; Echiburú López, Bárbara; Smith Garcés, Rosita; Rojas García, Pedro; Recabarren, Mónica; Rey, Rodolfo A. (ENDOCRINE SOC, 2008-09)
      Context: An important proportion of male members of polycystic ovary syndrome (PCOS) families exhibit insulin resistance and related metabolic defects. However, the reproductive phenotypes in first-degree male relatives ...
    • Pituitary and testis responsiveness of young male sheep exposed to testosterone excess during fetal development 

      Recabarren, Mónica P.; Rojas García, Pedro; Einspanier, Ralf; Padmanabhan, Vasantha; Sir Petermann, Lidia; Recabarren, Sergio E. (Society for Reproduction and Fertility, 2013)
      Prenatal exposure to excess testosterone induces reproductive disturbances in both female and male sheep. In females, it alters the hypothalamus–pituitary–ovarian axis. In males, prenatal testosterone excess reduces sperm ...
    • Polycystic ovary syndrome and pregnancy Síndrome de ovario poliquístico y embarazo 

      Sir Petermann, Teresa; Ladrón de Guevara, Amanda; Villarroel, Ana Claudia; Preisler, Jessica; Echiburú López, Bárbara; Recabarren, Sergio (2012)
      Polycystic ovary syndrome (PCOS) is a common endocrine metabolic dysfunction closely associated with insulin resistance and obesity, which predisposes to pregnancy complications and prenatal programming of the offspring. ...
    • Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone 

      Recabarren, Sergio E.; Padmanabhan, Vasantha; Codner Dujovne, Ethel; Lobos, Alejandro; Durán, Claudio; Vidal, Mónica; Foster, Douglas L.; Sir Petermann, Lidia (AMER PHYSIOLOGICAL SOC, 2005-11)
      Prenatally testosterone (T)-treated female sheep exhibit ovarian and endocrinological features that resemble those of women with polycystic ovarian syndrome ( PCOS), which include luteinizing hormone excess, polyfollicular ...
    • Prenatal exposure to androgens as a factor of fetal programming La exposición prenatal a andrógenos como factor de reprogramación fetal 

      Recabarren, Sergio E.; Sir Petermann, Teresa; Maliqueo Yevilao, Manuel; Lobos, Alejandro; Rojas García, Pedro (2006)
      Both epidemiological and clinical evidence suggest a relationship between the prenatal environment and the risk of developing diseases during adulthood. The first observations about this relationship showed that prenatal ...
    • Prenatal testosterone excess alters Sertoli and germ cell number and testicular FSH receptor expression in rams 

      Rojas García, Pedro; Recabarren, Mónica P.; Sarabia, Luis; Schön, Jennifer; Gabler, Christoph; Einspanier, Ralf; Maliqueo Yevilao, Manuel; Sir Petermann, Teresa; Rey, Rodolfo; Recabarren, Sergio E. (2010)
      Exposure to excess testosterone (T) during fetal life has a profound impact on the metabolic and reproductive functions in the female's postnatal life. However, less is known about the effects of excess testosterone in ...
    • Prenatal Testosterone Excess Reduces Sperm Count and Motility 

      Recabarren, Sergio E.; Rojas García, Pedro; Recabarren, Mónica; Alfaro, Víctor H.; Smith Garcés, Rosita; Padmanabhan, Vasantha; Sir Petermann, Lidia (ENDOCRINE SOC, 2008-12)
      The reproductive system is extremely susceptible to insults from exposure to exogenous steroids during development. Excess prenatal testosterone exposure programs neuroendocrine, ovarian, and metabolic deficits in the ...
    • Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep 

      Recabarren, Sergio E.; Lobos, Alejandro; Figueroa, Yara; Padmanabhan, Vasantha; Foster, Douglas L.; Sir Petermann, Teresa (Society of Biology of Chile, 2007)
      Although evidence is accumulating that prenatal testosterone (T) compromises reproductive function in the female, the effects of excess T in utero on the postnatal development of male reproductive function has not been ...
    • Response to the gonadotropin releasing hormone agonist leuprolide in immature female sheep androgenized in utero 

      Recabarren, Sergio E.; Sir Petermann, Lidia; Lobos, Alejandro; Codner Dujovne, Ethel; Rojas García, Pedro; Reyes Catalán, Víctor (SOCIEDAD BIOLGIA CHILE, 2005)
      Similar to women with Polycystic Ovary Syndrome (PCOS), female sheep treated prenatally with testosterone (T-females) are hypergonadotropic, exhibit neuroendocrine defects, multifollicular ovarian morphology, hyperinsulinemia ...
    • Secretory patterns of leptin and luteinizing hormone in food-restricted young female sheep 

      Recabarren, Sergio E.; Lobos, Alejandro; Torres, Verónica; Oyarzo, Roberto; Sir Petermann, Teresa (Society of Biology of Chile, 2004)
      Leptin, the product of the ob gene, has been proposed as a metabolic signal that regulates the secretion of GnRH/LH. This may be critical during prepubertal development to synchronize information about energy stores and ...