Browsing by Author "79b279aa-9e72-4e9d-96b4-0c5542cc2d28"

Now showing items 1-16 of 16

    • Calcium-dependent inactivation controls cardiac L-type Ca2+ currents under β-adrenergic stimulation 
      Morales, Danna; Hermosilla, Tamara; Varela, Diego (NLM (Medline), 2019)
      The activity of L-type calcium channels is associated with the duration of the plateau phase of the cardiac action potential (AP) and it is controlled by voltage- and calcium-dependent inactivation (VDI and CDI, respectively). ...
    • Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca 
      Cerda, Oscar; Cáceres, Mónica; Park, Kang Sik; Leiva Salcedo, Elías; Romero, Aníbal; Varela, Diego; Trimmer, James S.; Stutzin Schottlander, Andrés (Springer Verlag, 2015)
      © 2014, Springer-Verlag Berlin Heidelberg. Transient receptor potential melastatin-like 4 (TRPM4) is a Ca<sup>2+</sup>-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 ...
    • Cavβ2 transcription start site variants modulate calcium handling in newborn rat cardiomyocytes 
      Moreno, Cristian; Hermosilla, Tamara; Morales, Danna; Encina, Matías; Torres-Díaz, Leandro; Díaz, Pablo; Sarmiento, Daniela; Simon, Felipe; Varela, Diego (Springer Verlag, 2015)
      © 2015, Springer-Verlag Berlin Heidelberg.In the heart, the main pathway for calcium influx is mediated by L-type calcium channels, a multi-subunit complex composed of the pore-forming subunit CaV1.2 and the auxiliary ...
    • Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ ... 
      Gatica, Sebastian; Eltit, Felipe; Santibanez, Juan F.; Varela, Diego; Cabello-Verrugio, Claudio; Simon, Felipe (NLM (Medline), 2019)
      Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND: Main pathological features detected during sepsis and endotoxemia include over-secretion of pro-inflammatory ...
    • FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via ... 
      Urra, Félix A.; Hernández Muñoz, Felipe Andrés; Córdova Delgado, Miguel; Ramírez, María Paz; Peña Ahumada, Bárbara; Rios, Melany; Cruz, Pablo; Ahumada-Castro, Ulises; Bustos, Galdo; Silva-Pavez, Eduardo; Pulgar Tejo, Rodrigo; Morales, Danna; Varela, Diego; Millas-Vargas, Juan Pablo; Retamal (Nature Publishing Group, 2018)
      © 2018, The Author(s).Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking ...
    • Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death 
      Simon, Felipe; Leiva Salcedo, Elías; Armisen Yáñez, Ricardo; Riveros, Ana; Cerda, Oscar; Varela, Diego; Eguiguren, Ana Luisa; Olivero, Pablo; Stutzin Schottlander, Andrés (2010)
      Necrosis is associated with an increase in plasma membrane permeability, cell swelling, and loss of membrane integrity with subsequent release of cytoplasmic constituents. Severe redox imbalance by overproduction of reactive ...
    • Hydroxyl radical activation of a Ca2+-sensitive nonselective cation channel involved in epithelial cell necrosis 
      Simon, Felipe; Varela, Diego; Eguiguren, Ana Luisa; Díaz, Laín F.; Sala, Francisco; Stutzin Schottlander, Andrés (2004)
      In a previous work the involvement of a fenamate-sensitive Ca 2+-activated nonselective cation channel (NSCC) in free radical-induced rat liver cell necrosis was demonstrated (5). Therefore, we studied the effect of radical ...
    • Increased expression of the transient receptor potential melastatin 7 channel is critically involved in ... 
      Núñez-Villena, Felipe; Becerra, Alvaro; Echeverría, Cesar; Briceño, Nicolás; Porras Espinoza, Omar; Armisen Yáñez, Ricardo; Varela, Diego; Montorfano, Ignacio; Sarmiento, Daniela; Simon, Felipe (2011)
      Aims: To assess the mechanisms involved in lipopolysaccharide (LPS)-induced neuronal cell death, we examined the cellular consequences of LPS exposure in differentiated PC12 neurons and primary hippocampal neurons. Results: ...
    • Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity 
      Hernández, Helen; Parra, Alejandra; Tobar, Nicolas; Molina, Jessica; Kallens, Violeta; Hidalgo, Miltha; Varela, Diego; Martínez, Jorge; Porras Espinoza, Omar (Elsevier B.V., 2018)
      © 2018 The Authors Aerobic metabolism brings inexorably the production of reactive oxygen species (ROS), which are counterbalanced by intrinsic antioxidant defenses avoiding deleterious intracellular effects. Redox balance ...
    • L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes 
      Hermosilla, Tamara; Moreno, Cristian; Itfinca, Mircea; Altier, Christophe; Armisen Yáñez, Ricardo; Stutzin Schottlander, Andrés; Zamponi, Gerald W.; Varela, Diego (Taylor and Francis Inc., 2011)
      Angiotensin II regulation of L-type calcium currents in cardiac muscle is controversial and the underlying signaling events are not completely understood. Moreover, the possible role of auxiliary subunit composition of the ...
    • Non-selective cation channels and oxidative stress-induced cell swelling 
      Simon, Felipe; Varela, Diego; Riveros, Ana; Eguiguren, Ana Luisa; Stutzin Schottlander, Andrés (Society of Biology of Chile, 2002)
      Necrosis is considered as a non-specific form of cell death that induces tissue inflammation and is preceded by cell swelling. This increase in cell volume has been ascribed mainly to defective outward pumping of Na+ caused ...
    • OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB ... 
      Pérez, Lorena; Vallejos, Alejandro; Echeverria, Cesar; Varela, Diego; Cabello-Verrugio, Claudio; Simon, Felipe (Nature Publishing Group, 2019)
      © 2019, United States & Canadian Academy of Pathology.Systemic inflammatory diseases enhance circulating oxidative stress levels, which results in the oxidation of circulating high-density lipoprotein (oxHDL). Endothelial ...
    • Prolonged AT(1)R activation induces Ca(V)1.2 channel internalization in rat cardiomyocytes 
      Hermosilla, Tamara; Encina, Matías; Morales, Danna; Moreno, Cristian; Conejeros, Carolina; Alfaro Valdés, Hilda M.; Lagos Meza, Felipe; Simon, Felipe; Altier, Christophe; Varela, Diego (Nature Publishing Group, 2017)
      The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling of the pore-forming subunit Ca(V)1.2 with auxiliary subunits Ca-V alpha 2 delta and Ca-V beta. Its traffic has been shown to be ...
    • Sarcopenia and androgens: A link between pathology and treatment 
      Basualto-Alarcón, Carla; Varela, Diego; Duran, Javier; Maass, Rodrigo; Estrada, Manuel (Frontiers Media S.A., 2014)
      © 2014 Basualto-Alarcón, Varela, Duran, Maass and Estrada.Sarcopenia, the age-related loss of skeletal muscle mass and function, is becoming more prevalent as the lifespan continues to increase in most populations. As ...
    • Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells ... 
      Echeverría, Cesar; Montorfano, Ignacio; Cabello Verrugio, Claudio; Armisén, Ricardo; Varela, Diego; Simon, Felipe (Lippincott Williams and Wilkins, 2015)
      © 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins.Objective: To study whether transient receptor potential melastatin 4 (TRPM4) participates in endothelial fibrosis and to investigate the underlying mechanism. ...
    • Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death 
      Becerra, Alvaro; Echeverra, Cesar; Varela, Diego; Sarmiento, Daniela; Armisn, Ricardo; Nuez-Villena, Felipe; Montecinos, Mario; Simon, Felipe (2011)
      Aims Endothelial dysfunction is decisive in the progression of cardiovascular diseases. Lipopolysaccharide (LPS)-induced reactive oxygen species (ROS)-mediated endothelial cell death is a main feature observed in inflammation ...