Browsing by Author "79f3edf2-bad5-486b-972a-98329b941ae5"

Now showing items 1-4 of 4

    • Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease 
      Salazar, Julio; Mena, Natalia P.; Hunot, Stephane; Prigent, Annick; Alvarez Fischer, Daniel; Arredondo, Miguel; Duyckaerts, Charles; Sazdovitch, Veronique; Zhao, Lin; Garrick, Laura M.; Núñez González, Marco; Garrick, Michael D.; Raisman Vozari, Rita; Hirsch, Etienne C. (2008)
      Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in ...
    • Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following ... 
      Bulteau, Anne Laure; Mena, Natalia P.; Auchere, Francoise; Lee, Irene; Prigent, Annick; Lobsiger, Christian S.; Camadro, Jean Michel; Hirsch, Etienne C. (Elsevier, 2017)
      Compelling evidence suggests that mitochondrial dysfunction leading to reactive oxygen species (ROS) production and protein oxidation could represent a critical event in the pathogenesis of Parkinson's disease (PD). ...
    • Effect of mitochondrial complex I inhibition on Fe-S cluster protein activity 
      Mena, Natalia P.; Bulteau, Anne Laure; Salazar, Julio; Hirsch, Etienne C.; Núñez González, Marco (2011)
      Iron-sulfur (Fe-S) clusters are small inorganic cofactors formed by tetrahedral coordination of iron atoms with sulfur groups. Present in numerous proteins, these clusters are involved in key biological processes such as ...
    • Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia 
      Urrutia, Pamela J.; Hirsch, Etienne C.; González Billault, Christian; Núñez González, Marco (Wiley, 2017)
      Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid-beta (A beta) induces inflammation and oxidative stress, which have ...