Browsing by Author "7ad05f03-e98a-4fa8-a809-74e8bff50fd0"

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    • Molecular Determinants for Competitive Inhibition of 4 2 Nicotinic Acetylcholine Receptors 
      Iturriaga-Vásquez, Patricio; Carbone, Annalisa; García Beltrán, Olimpo; Livingstone, Phil D.; Biggin, Philip C.; Cassels Niven, Bruce; Wonnacott, Susan; Zapata-Torres, Gerald; Bermúdez, Isabel (The American Society for Pharmacology and Experimental Therapeutics, 2010-06-14)
      The Erythrina alkaloids erysodine and dihydro- -erythroidine (DH E) are potent and selective competitive inhibitors of 4 2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants ...
    • Molecular determinants for competitive inhibition of α4β2 nicotinic acetylcholine receptors 
      Iturriaga-Vásquez, Patricio; Carbone, Annalisa; García Beltrán, Olimpo; Livingstone, Phil D.; Biggin, Philip C.; Cassels Niven, Bruce; Wonnacott, Susan; Zapata Torres, Gerald; Bermudez, Isabel (American Society for Pharmacology and Experimental Therapy, 2010)
      The Erythrina alkaloids erysodine and dihydro-β-erythroidine (DHβE) are potent and selective competitive inhibitors of α4β2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants ...
    • Non-equivalent ligand selectivity of agonist sites in (α4β2) 2α4 nicotinic acetylcholine receptors: A key ... 
      Mazzaferro, Simone; Gasparri, Federica; New, Karina; Alcaino, Constanza; Faundez, Manuel; Vasquez, Patricio Iturriaga; Vijayan, Ranjit; Biggin, Philip C.; Bermudez, Isabel (American Society for Biochemistry and Molecular Biology Inc., 2014)
      The α4β2 nicotinic acetylcholine receptor (nAChR) is the most abundant nAChR type in the brain, and this receptor type exists in alternate (α4β2)2α4 and (α4β2)2β2 forms, which are activated by agonists with strikingly ...
    • Role of the cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine ... 
      Alcaino, Constanza; Musgaard, Maria; Minguez, Teresa; Mazzaferro, Simone; Faundez, Manuel; Iturriaga-Vásquez, Patricio; Biggin, Philip C.; Bermudez, Isabel (American Society for Biochemistry and Molecular Biology Inc., 2017)
      © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel ...