Now showing items 1-3 of 3

    • A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway 

      Zamorano, Sebastián; Rojas Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero González, Sergio; Hetz Flores, Claudio (2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore 

      Barrientos, Sebastián A.; Martínez, Nicolas W.; Yoo, Soonmoon; Jara, Juan S.; Zamorano, Sebastián; Hetz Flores, Claudio; Twiss, Jeffery L.; Alvarez, Jaime; Court, Felipe A. (SOC NEUROSCIENCE, 2011-01-19)
      Axonal degeneration is an active process that has been associated with neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This degenerative process can ...
    • BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1 alpha 

      Lisbona, Fernanda; Rojas Rivera, Diego; Thielen, Peter; Zamorano, Sebastián; Todd, Derrick; Martinon, Fabio; Glavic Maurer, Álvaro; Kress, Christina; Lin, Jonathan H.; Walter, Peter; Reed, John C.; Glimcher, Laurie H.; Hetz Flores, Claudio (CELL PRESS, 2009-03-27)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ...