Browsing by Author "7b34917f-016a-48dc-91dd-5b0cc7135bab"

Now showing items 1-9 of 9

    • Addicted to secrete - novel concepts and targets in cancer therapy 
      Dejeans, Nicolas; Manié, Serge; Hetz Flores, Claudio; Bard, Frédéric; Hupp, Ted; Agostinis, Patrizia; Samali, Afshin; Chevet, Eric (Elsevier Ltd, 2014)
      The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic ...
    • Emerging roles of the endoplasmic reticulum associated unfolded protein response in cancer cell migration ... 
      Limia, Celia Maria; Sauzay, Chloé; Urra, Hery; Hetz Flores, Claudio; Chevet, Eric; Avril, Tony (MDPI AG, 2019)
      Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic (oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress triggers the activation of an adaptive response ...
    • Endoplasmic reticulum proteostasis in glioblastoma - From molecular mechanisms to therapeutic perspectives 
      Obacz, Joanna; Avril, Tony; Le Reste, Pierre Jean; Urra, Hery; Quillien, Véronique; Hetz Flores, Claudio; Chevet, Eric (American Association for the Advancement of Science, 2017)
      © 2017 The Authors, some rights reserved.Cellular stress induced by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) is a central feature of secretory cells and is observed in many tissues in various ...
    • Endoplasmic Reticulum Stress and the Hallmarks of Cancer 
      Urra, Hery; Dufey, Estefanie; Avril, Tony; Chevet, Eric; Hetz Flores, Claudio (Cell Press, 2016)
      © 2016 Elsevier Inc. Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis, thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an adaptive mechanism ...
    • Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease 
      Lebeaupin, Cynthia; Vallée, Deborah; Hazari, Younis; Hetz Flores, Claudio; Chevet, Eric; Bailly-Maitre, Béatrice (Elsevier B.V., 2018)
      © 2018 The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non-alcoholic steatohepatitis, potentially ...
    • Genotoxic stress triggers the activation of IRE1 alpha-dependent RNA decay to modulate the DNA damage response 
      Dufey, Estefanie; Bravo San Pedro, José; Eggers Aracena, Cristián; González Quiroz, Matías; Urra Zúñiga, Hery; Sagredo Campos, Alfredo; Sepúlveda Alvarado, Denisse; Pihán Najle, Philippe; Carreras Sureda, Armando; Hazari, Younis; Sagredo, Eduardo A.; Gutiérrez, Daniela; Valls, Cristian; Papaioannou, Alexandra; Acosta Alvear, Diego; Campos, Gisela; Domingos, Pedro M.; Pedeux, Rémy; Chevet, Eric; Álvarez, Alejandra R.; Godoy, Patricio; Walter, Peter; Glavic Maurer, Álvaro; Kroemer, Guido; Hetz Flores, Claudio (Nature, 2020)
      The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1 ...
    • IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A 
      Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Theme Series - UPR in cancer 
      Hetz Flores, Claudio; Chevet, Eric (Academic Press, 2015)
    • When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response 
      González Quiroz, Matías; Blondel, Alice; Sagredo, Alfredo; Hetz Flores, Claudio; Chevet, Eric; Pedeux, Remy (Elsevier, 2020)
      Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response ...