Browsing by Author "818beb4a-4e24-4649-aff3-f36fd28b13bc"

Now showing items 1-4 of 4

    • HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence ... 
      Villota, Claudio; Varas-Godoy, Manuel; Jeldes, Emanuel; Campos, América; Villegas, Jaime; Borgna, Vincenzo; Burzio, Luis O.; Burzio, Verónica A. (Impact Journals LLC, 2019)
      © Villota et al. Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal proliferating and cancer cells express a ...
    • In vivo knockdown of antisense non-coding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma ... 
      Varas Godoy, Manuel; Lladser, Álvaro; Farfan, Nicole; Villota, Claudio; Villegas, Jaime; Tapia Pineda, Julio; Burzio, Luis O.; Burzio, Verónica A.; Valenzuela, Pablo D. T. (Wiley, 2018)
      The family of non-coding mitochondrial RNAs (ncmtRNA) is differentially expressed according to proliferative status. Normal proliferating cells express sense (SncmtRNA) and antisense ncmtRNAs (ASncmtRNAs), whereas tumor ...
    • Localization of the 16S mitochondrial rRNA in the nucleus of mammalian spermatogenic cells 
      Villegas, Jaime; Araya, Pamela; Bustos-Obregon, Eduardo; Burzio, Luis O. (2002)
      Amplification of RNA from human sperm heads yielded a fragment of 435 bp that shares 100% identity with a central region of the 16S mitochondrial rRNA. The nuclear localization in the sperm of the mitochondrial RNA was ...
    • Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through ... 
      Lobos González, Lorena; Silva, Verónica; Araya, Mariela; Restovic, Franko; Echeñique, Javiera; Oliveira Cruz, Luciana; Fitzpatrick, Christopher; Briones, Macarena; Villegas, Jaime; Villota, Claudio; Vidaurre, Soledad; Borgna, Vincenzo; Socias, Miguel; Valenzuela, Sebastián; López, Constanza; Socias, Teresa; Varas, Manuel; Díaz, Jorge; Burzio, Luis O.; Burzio, Verónica A. (Impact Journals, 2016)
      We reported that knockdown of the antisense noncoding mitochondrial RNAs (ASncmtRNAs) induces apoptotic death of several human tumor cell lines, but not normal cells, suggesting this approach for selective therapy against ...