Now showing items 1-8 of 8

    • A convenient synthesis of benzo[g]pyrrolo[3,2-c]quinoline-6,11-diones 

      Tapia, Ricardo A.; López, Claudio; Morello, Antonio; Maya Arango, Juan; Valderrama, Jaime A. (2005)
      The synthesis of a new class of angular tetracyclic quinones is described. Our strategy involves Diels-Alder reaction of pyrroloquinolinequinone 9, generated in situ from pyrroloquinoline 8, and dienes. The required ...
    • Access to quinazolines from 2-nitrobenzaldehyde and arylamines 

      Valderrama, Jaime A.; Pessoa Mahana, Hernán; Sarras, Gabriela; Tapia, Ricardo (1999)
      A synthesis of N-(2-nitrobenzyl)acetanilide (5) and (11) from 2- nitrobenzaldehyde and aromatic amines is reported. The reaction of amides (5) and (11) with iron in acetic acid-ethanol-water provided the corresponding 3- ...
    • In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones 

      Benites, Julio; Toledo, Héctor; Salas, Felipe; Guerrero, Angélica; Rios, David; Valderrama, Jaime A.; Calderon, Pedro Buc (2018)
      Infection by Helicobacter pylori increases 10 times the risk of developing gastric cancer. Juglone, a natural occurring 1,4-naphthoquinone, prevents H. pylori growth by interfering with some of its critical metabolic ...
    • Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones 

      Benites, Julio; Valderrama, Jaime A.; Ríos, David; Lagos Mónaco, Rosalba; Monasterio Opazo, Octavio; Buc Calderón, Pedro (2016)
      Dihydroxynaphthyl aryl ketones 1-5 exhibit activity as tubulin polymerization inhibitors by targeting the colchicine binding site of microtubules making them potential anticancer drugs. Therefore, analogues 1-5 have been ...
    • Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta 

      Palacios, Javier; Cifuentes, Fredi; Valderrama, Jaime A.; Benites, Julio; Ríos, David; González, Constanza; Chiong Lay, Mario; Cartes Saavedra, Benjamín; Lafourcade, Carlos; Wyneken, Úrsula (2016)
      The vascular endotheliumplays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a ...
    • Regioselectivity in the Diels-Alder reaction of 8,8- dimethylnaphthalene-1,4,5(8H)-trione with 2,4-hexadien-1-ol 

      Araya Maturana, Ramiro; Cassels Niven, Bruce; Delgado Castro, Tomás; Valderrama, Jaime A.; Weiss López, Boris (Elsevier Ltd, 1999)
      The Diels-Alder reactions of 8,8-dimethylnaphtalene-1,4,5(8H)-trione with 2,4-hexadien-1-ol and its O-acetyl derivative were investigated in different solvents. The regiochemistry of the cycloaddition of the hexadienol was ...
    • Studies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1,4-quinones 

      Valderrama, Jaime A.; Benites, Julio; Cortés, Manuel; Pessoa Mahana, Hernán; Prina, Eric; Fournet, Alain (PERGAMON-ELSEVIER SCIENCE LTD, 2003-11-03)
      The reaction of (+)-euryfuran 1 with several benzo-, naphtho- and benzo[b]thiophene-1,4-quinones in acetic acid yields the corresponding euryfuryl-1.4-quinones 3, 5, 7, 8, 10, 12, and 14. The structure of compounds 7, 8, ...
    • Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents 

      Tapia, Ricardo A.; Carrasco, Claudia; Ojeda, Scarlet; Salas, Cristian; Valderrama, Jaime A.; Morello, Antonio; Repetto, Yolanda (2002)
      The synthesis of new indazol-4,7-dione derivatives via 1,3-dipolar cycloaddition of diazomethane with 2,3-dimethyl-1,4-benzoquinone (2) and 1,4-naphthoquinone (7) followed by N-alkylation of the pyrazol nitrogen atom of ...